tert‐Butyl as a Functional Group: Non‐Directed Catalytic Hydroxylation of Sterically Congested Primary C−H Bonds DOI Creative Commons
Siu‐Chung Chan, Andrea Palone, Massimo Bietti

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(28)

Опубликована: Май 1, 2024

Abstract The tert ‐butyl group is a common aliphatic motif extensively employed to implement steric congestion and conformational rigidity in organic organometallic molecules. Because of the combination high bond dissociation energy (~100 kcal mol −1 ) limited accessibility, absence directing groups, neither radical nor approaches are effective for chemical modification C−H bonds. Herein we overcome these limits by employing highly electrophilic manganese catalyst, [Mn( CF3 bpeb)(OTf) 2 ], that operates strong hydrogen donor solvent nonafluoro‐ alcohol (NFTBA) catalytically activates peroxide generate powerful manganese‐oxo species effectively oxidizes Leveraging on interplay steric, electronic, medium torsional effects, site‐selective product chemoselective hydroxylation accomplished with broad reaction scope, delivering primary alcohols as largely dominant products preparative yields. Late‐stage at sites demonstrated 6 densely functionalized molecules pharmaceutical interest. This work uncovers novel disconnection approach, harnessing potential functional strategic synthetic planning complex molecular architectures.

Язык: Английский

C–H Bonds as Functional Groups: Simultaneous Generation of Multiple Stereocenters by Enantioselective Hydroxylation at Unactivated Tertiary C–H Bonds DOI Creative Commons
Andrea Palone, Guillem Casadevall, Sergi Ruiz‐Barragán

и другие.

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(29), С. 15742 - 15753

Опубликована: Июль 11, 2023

Enantioselective C–H oxidation is a standing chemical challenge foreseen as powerful tool to transform readily available organic molecules into precious oxygenated building blocks. Here, we describe catalytic enantioselective hydroxylation of tertiary bonds in cyclohexane scaffolds with H2O2, an evolved manganese catalyst that provides structural complementary the substrate similarly lock-and-key recognition operating enzymatic active sites. Theoretical calculations unveil enantioselectivity governed by precise fitting scaffold site, through network weak non-covalent interactions. Stereoretentive C(sp3)–H results single-step generation multiple stereogenic centers (up 4) can be orthogonally manipulated conventional methods providing rapid access, from single precursor variety chiral scaffolds.

Язык: Английский

Процитировано

24

An Active Site Tyr Residue Guides the Regioselectivity of Lysine Hydroxylation by Nonheme Iron Lysine-4-hydroxylase Enzymes through Proton-Coupled Electron Transfer DOI Creative Commons
Yuanxin Cao, Sam Hay, Sam P. de Visser

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(17), С. 11726 - 11739

Опубликована: Апрель 18, 2024

Lysine dioxygenase (KDO) is an important enzyme in human physiology involved bioprocesses that trigger collagen cross-linking and blood pressure control. There are several KDOs nature; however, little known about the factors govern regio- stereoselectivity of these enzymes. To understand how can selectively hydroxylate their substrate, we did a comprehensive computational study into mechanisms features 4-lysine dioxygenase. In particular, selected snapshot from MD simulation on KDO5 created large QM cluster models (A, B, C) containing 297, 312, 407 atoms, respectively. The largest model predicts regioselectivity matches experimental observation with rate-determining hydrogen atom abstraction C4–H position, followed by fast OH rebound to form 4-hydroxylysine products. calculations show C, dipole moment positioned along bond substrate and, therefore, electrostatic electric field perturbations protein assist creating hydroxylation selectivity. Furthermore, active site Tyr233 residue identified reacts through proton-coupled electron transfer akin axial Trp cytochrome c peroxidase. Thus, upon formation iron(IV)-oxo species catalytic cycle, phenol loses proton nearby Asp179 residue, while at same time, transferred iron create iron(III)-oxo species. This charged tyrosyl directs guides selectivity C4-hydroxylation substrate.

Язык: Английский

Процитировано

14

Hydrogen‐Bond‐Mediated Formation of C−N or C=N Bond during Photocatalytic Reductive Coupling Reaction over CdS Nanosheets DOI
Jie He, Bo Han,

Chensheng Xian

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(26)

Опубликована: Апрель 19, 2024

Abstract Reductive amination of carbonyl compounds and nitro represents a straightforward way to attain imines or secondary amines, but it is difficult control the product selectivity. Herein, we report selective formation C−N C=N bond readily manipulated through solvent‐induced hydrogen bridge, facilitating swift photocatalytic reductive coupling process. The reductive‐coupling with using formic acid sodium formate as donors over CdS nanosheets selectively generates bonds in acetonitrile solvent; while taking methanol solvent, are hydrogenated via hydrogen‐bonding activation. Experimental theoretical study reveals that building hydrogen‐bond bridge between hydroxyl groups N atoms motifs facilitates transfer from surface upon illumination, resulting rapid hydrogenation give rise amines bonds. Our method provides simple selectivity by altering solvents organic transformations.

Язык: Английский

Процитировано

9

Heme and nonheme high-valent manganese(V)-oxo complexes: Synthesis, characterization, and reactivity DOI
Chunxia Wu, Jie Chen, Wonwoo Nam

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 528, С. 216429 - 216429

Опубликована: Янв. 11, 2025

Язык: Английский

Процитировано

1

Rhodium-Catalyzed Homogeneous Asymmetric Hydrogenation of Naphthol Derivatives DOI
Shuxin Zhang, Linhong Long, Zeyu Li

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Due to their strong aromaticity and difficulties in chemo-, regio-, enantioselectivity control, asymmetric hydrogenation of naphthol derivatives 1,2,3,4-tetrahydronaphthols has remained a long-standing challenge. Herein, we report the first example homogeneous catalyzed by tethered rhodium-diamine catalysts, affording wide array optically pure high yields with excellent enantioselectivities (up 98% yield >99% ee). Mechanistic studies experimental computational approaches reveal that fluorinated solvent 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) plays vital roles control reactivity selectivity, 1-naphthol is reduced via cascade reaction pathway, including dearomative tautomerization, 1,4-hydride addition, 1,2-hydride addition sequence. A novel synergistic activation mode was proposed which HFIP assists both hydrogen molecule presence base, situ-generated fleeting keto tautomer immediately trapped Rh(III)-H species before it escapes from cage. This protocol provides straightforward practical pathway for synthesis key intermediates several chiral drugs. Particularly, Nadolol, drug treatment hypertension, angina pectoris, congestive heart failure, certain arrhythmias, enantioselectively synthesized time.

Язык: Английский

Процитировано

1

Mechanisms of C(sp3)–H and C=C selective oxidative heterofunctionalizations by non-heme Fe and Mn mimics of oxygenase enzymes DOI
Konstantin P. Bryliakov

Coordination Chemistry Reviews, Год журнала: 2024, Номер 508, С. 215793 - 215793

Опубликована: Март 18, 2024

Язык: Английский

Процитировано

9

Catalyst and Medium Control over Rebound Pathways in Manganese-Catalyzed Methylenic C–H Bond Oxidation DOI Creative Commons
Marco Galeotti, Massimo Bietti, Miguel Costas

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(13), С. 8904 - 8914

Опубликована: Март 20, 2024

The C(sp3)–H bond oxygenation of a variety cyclopropane containing hydrocarbons with hydrogen peroxide catalyzed by manganese complexes aminopyridine tetradentate ligands was carried out. Oxidations were performed in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) and 2,2,2-trifluoroethanol (TFE) using different catalysts carboxylic acid co-ligands, where steric electronic properties systematically modified. Functionalization selectively occurs at the most activated C–H bonds that are α- to cyclopropane, providing access carboxylate or 2,2,2-trifluoroethanolate transfer products, no competition, favorable cases, from generally dominant hydroxylation reaction. formation mixtures unrearranged rearranged esters (oxidation HFIP presence acid) ethers TFE) full control over diastereoselectivity observed, confirming involvement delocalized cationic intermediates these transformations. Despite such complex mechanistic scenario, fine-tuning catalyst sterics electronics leveraging on relative contribution pathways reaction mechanism, product chemoselectivity could be achieved. Taken together, results reported herein provide powerful catalytic tools rationally manipulate ligand oxidations hydrocarbons, delivering novel products good yields and, some outstanding selectivities, expanding available toolbox for development synthetically useful functionalization procedures.

Язык: Английский

Процитировано

7

A preparative small-molecule mimic of liver CYP450 enzymes in the aliphatic C–H oxidation of carbocyclic N -heterocycles DOI Creative Commons
Rachel K. Chambers, J. D. III WEAVER, Jinho Kim

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(29)

Опубликована: Июль 10, 2023

An emerging trend in small-molecule pharmaceuticals, generally composed of nitrogen heterocycles (

Язык: Английский

Процитировано

15

Highly Selective C(sp3)–H Bond Oxygenation at Remote Methylenic Sites Enabled by Polarity Enhancement DOI Creative Commons

Sergio Sisti,

Marco Galeotti,

Filippo Scarchilli

и другие.

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(40), С. 22086 - 22096

Опубликована: Сен. 26, 2023

A detailed study on the C(sp3)–H bond oxygenation reactions with H2O2 catalyzed by [Mn(OTf)2(TIPSmcp)] complex at methylenic sites of cycloalkyl and 1-alkyl substrates bearing 19 different electron-withdrawing functional groups (EW FGs) was carried out. Oxidations in MeCN were compared to corresponding ones strong hydrogen donating (HBD) solvents 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) nonafluoro tert-butyl alcohol (NFTBA). Formation products deriving from most remote observed, yields, product ratios (PR) for over next sites, associated site-selectivities that significantly increased going HFIP NFTBA. Unprecedented obtained oxidation cyclohexyl, cycloheptyl, cyclooctyl, 1-pentyl, 1-hexyl, 1-heptyl substrates, approaching >99%, 90%, 93%, 88% (PR >99, 9.4, 14, 7.5) cyclohexyl-2-pyridinecarboxylate, cycloheptyl-2-pyridinecarboxylate, cyclooctyl-4-nitrobenzenesulfonamide, 1-pentyl-3,5-dinitrobenzoate, 1-hexyl-3,5-dinitrobenzoate, 1-heptyl-3,5-dinitrobenzoate, respectively. The results are rationalized basis a polarity enhancement effect via synergistic electronic deactivation proximal imparted EWG coupled solvent HB. Compared previous procedures, provides opportunity tune site-selectivity among multiple methylenes substrate classes, extending determined native EWGs two carbon atoms. This uncovers simple procedure predictable, high-yielding, highly site-selective occurs under mild conditions, large scope, providing an extremely powerful tool be implemented synthetically useful procedures.

Язык: Английский

Процитировано

13

Bioinspired Non‐Heme Mn Catalysts for Regio‐ and Stereoselective Oxyfunctionalizations with H2O2 DOI
Roman V. Ottenbacher,

Anna A. Bryliakova,

Vladimir I. Kurganskii

и другие.

Chemistry - A European Journal, Год журнала: 2023, Номер 29(66)

Опубликована: Авг. 29, 2023

Abstract In recent years, metalloenzymes‐mediated highly selective oxidations of organic substrates under mild conditions have been inspiration for developing synthetic bioinspired catalyst systems, capable conducting such processes in the laboratory (and, future, industry), relying on easy‐to‐handle and environmentally benign oxidants as H 2 O . To date, non‐heme manganese complexes with chiral bis ‐amino‐ ‐pyridylmethyl structurally related ligands are considered possessing highest potential, having demonstrated ability to mediate a variety chemo‐ stereoselective oxidative transformations, epoxidations, C(sp 3 )‐H hydroxylations ketonizations, desymmetrizations, kinetic resolutions, etc. Furthermore, past few years Mn based catalysts become major platform studies focused getting insight into molecular mechanisms oxidant activation (stereo)selective oxygen transfer, testing non‐traditional hydroperoxide oxidants, engineering catalytic sites enzyme‐like substrate recognition‐based selectivity, exploration regioselectivity trends oxidation biologically active natural origin. This contribution summarizes progress catalyzed C‐H oxygenative transformations substrates, achieved essentially 5 (late 2018–2023).

Язык: Английский

Процитировано

12