Custom-designed
additives
play
a
crucial
role
in
achieving
desired
transformations
under
aqueous
conditions
modern
organic
synthesis.
In
micellar
catalysis,
designer
amphiphilic
molecules
create
dynamic
supramolecular
structures
that
can
dissolve
reactants
and
catalysts
conditions.
This
enables
the
to
occur
mild
without
need
for
hazardous
solvents.
Additionally,
such
as
tetra
-butyl
ammonium
chloride
or
bromides
facilitate
reactions
through
efficient
transfer
of
reactive
species
between
non-miscible
biphasic
systems.
method,
known
phase-transfer
has
been
instrumental
challenging
asymmetric
chapter
overviews
recent
advancements
these
respective
fields,
outlining
fundamental
principles
underlying
their
operational
mechanisms.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(16), С. 6186 - 6194
Опубликована: Апрель 9, 2024
Solvatochromes
have
gained
great
attention
because
of
their
unique
roles
in
monitoring
biomolecular
location,
interaction,
and
dynamics.
Particularly,
solvatochromes
presenting
both
red-shifting
excitation
dual-band
switchable
emission
are
demand
yet
significantly
difficult
to
come
true.
In
this
article,
we
disclose
an
aromatic
alcohol-based
pH-sensitive
chromophore
NIR-HBT
that
not
only
presents
solvent-dependent
but
also
shows
high
photostability
excellent
brightness.
To
the
best
our
knowledge,
is
first
solvatochrome
simultaneously
display
these
optical
properties.
Especially,
contrast
reported
whose
solvatochromism
achieved
by
affecting
excited
state
behaviors,
realized
modulating
its
ground
proton
dissociation,
which
a
new
solvatochromic
mechanism
has
been
reported.
Furthermore,
based
on
intrinsic
binding
ability
GQs,
near-infrared
ratiometric
detection
GQs
achieved.
These
results
indicate
attractive
can
be
used
develop
biosensors
for
biological
research.
More
broadly,
discovered
open
horizons
exploring
solvatochrome.
In
the
field
of
molecular
self-assembly,
core
an
assembly
is
always
made
up
hydrophobic
moiety
like
a
long
alkyl
chain,
whereas
outer
part
has
been
hydrophilic
such
as
poly(ethylene
glycol)
(PEG),
or
charged
species.
Hence,
reversing
trend
to
manifest
self-assembled
structures
with
PEG
and
surface
consisting
chains
in
aqueous
system
incredibly
challenging.
Herein,
we
architected
unique
class
cationic
bolaamphiphiles
containing
low
weight
different
lengths.
The
spontaneously
form
vesicles
without
external
stimuli.
These
are
unprecedented
because
makes
vesicle
core,
while
appear
on
vesicles'
exterior.
this
particular
design
reverses
usual
self-assembly
formation.
size
increases
increase
chain-length.
To
our
great
surprise,
obtained
large
micelles
for
longest
alkyl-chain
amphiphile,
which
turn
act
gemini
amphiphile.
shift
from
bolaamphiphile
amphiphile
variation
chain
also
unexplored.
Therefore,
specific
structure
would
compound
new
paradigm
supramolecular
chemistry.
Helvetica Chimica Acta,
Год журнала:
2024,
Номер
107(9)
Опубликована: Авг. 11, 2024
Abstract
An
efficient
and
scalable
Buchwald‐Hartwig
amination
towards
the
synthesis
of
API
candidate
4‐((2‐Chlorophenyl)amino)‐6‐((6‐methylpyridin‐2‐yl)amino)nicotinamide
as
a
JAK
inhibitor
was
described.
The
process
developed
using
water
water‐miscible
co‐solvent.
It
facilitated
by
benign
design
surfactant
TPGS‐750‐M,
that
promoted
robust
reliable
preparation
our
target
compound
in
high
yields,
with
improved
reaction
profile
via
an
operationally
simple
protocol.
Custom-designed
additives
play
a
crucial
role
in
achieving
desired
transformations
under
aqueous
conditions
modern
organic
synthesis.
In
micellar
catalysis,
designer
amphiphilic
molecules
create
dynamic
supramolecular
structures
that
can
dissolve
reactants
and
catalysts
conditions.
This
enables
the
to
occur
mild
without
need
for
hazardous
solvents.
Additionally,
such
as
tetra
-butyl
ammonium
chloride
or
bromides
facilitate
reactions
through
efficient
transfer
of
reactive
species
between
non-miscible
biphasic
systems.
method,
known
phase-transfer
has
been
instrumental
challenging
asymmetric
chapter
overviews
recent
advancements
these
respective
fields,
outlining
fundamental
principles
underlying
their
operational
mechanisms.
