Angewandte Chemie,
Год журнала:
2023,
Номер
136(10)
Опубликована: Дек. 18, 2023
Abstract
Real‐time
monitoring
of
hydroxyl
radical
(⋅OH)
generation
is
crucial
for
both
the
efficacy
and
safety
chemodynamic
therapy
(CDT).
Although
⋅OH
probe‐integrated
CDT
agents
can
track
production
by
themselves,
they
often
require
complicated
synthetic
procedures
suffer
from
self‐consumption
⋅OH.
Here,
we
report
facile
fabrication
a
self‐monitored
agent
(denoted
as
Fc‐CD‐AuNCs)
incorporating
ferrocene
(Fc)
into
β‐cyclodextrin
(CD)‐functionalized
gold
nanoclusters
(AuNCs)
via
host–guest
molecular
recognition.
The
water‐soluble
CD
served
not
only
capping
to
protect
AuNCs
but
also
macrocyclic
host
encapsulate
solubilize
hydrophobic
Fc
guest
with
high
Fenton
reactivity
in
vivo
applications.
Importantly,
encapsulated
inside
possessed
strong
electron‐donating
ability
effectively
quench
second
near‐infrared
(NIR‐II)
fluorescence
through
photoinduced
electron
transfer.
After
internalization
Fc‐CD‐AuNCs
cancer
cells,
reaction
between
redox‐active
quencher
endogenous
hydrogen
peroxide
(H
2
O
)
caused
oxidation
subsequent
NIR‐II
recovery,
which
was
accompanied
formation
cytotoxic
therefore
allowed
situ
self‐report
without
undesired
consumption.
Such
fluorescence‐monitored
enabled
use
renal‐clearable
efficient
tumor
growth
inhibition
minimal
side
effects
vivo.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
Thiol-maleimide
(MI)
chemistry
is
a
cornerstone
of
bioconjugation
strategies,
particularly
in
the
development
drug
delivery
systems.
The
cyclic
arginine-glycine-aspartic
acid
(cRGD)
peptide,
recognized
for
its
ability
to
target
integrin
α
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(10)
Опубликована: Дек. 18, 2023
Real-time
monitoring
of
hydroxyl
radical
(⋅OH)
generation
is
crucial
for
both
the
efficacy
and
safety
chemodynamic
therapy
(CDT).
Although
⋅OH
probe-integrated
CDT
agents
can
track
production
by
themselves,
they
often
require
complicated
synthetic
procedures
suffer
from
self-consumption
⋅OH.
Here,
we
report
facile
fabrication
a
self-monitored
agent
(denoted
as
Fc-CD-AuNCs)
incorporating
ferrocene
(Fc)
into
β-cyclodextrin
(CD)-functionalized
gold
nanoclusters
(AuNCs)
via
host-guest
molecular
recognition.
The
water-soluble
CD
served
not
only
capping
to
protect
AuNCs
but
also
macrocyclic
host
encapsulate
solubilize
hydrophobic
Fc
guest
with
high
Fenton
reactivity
in
vivo
applications.
Importantly,
encapsulated
inside
possessed
strong
electron-donating
ability
effectively
quench
second
near-infrared
(NIR-II)
fluorescence
through
photoinduced
electron
transfer.
After
internalization
Fc-CD-AuNCs
cancer
cells,
reaction
between
redox-active
quencher
endogenous
hydrogen
peroxide
(H
Chemistry of Materials,
Год журнала:
2024,
Номер
36(9), С. 4054 - 4077
Опубликована: Апрель 18, 2024
Stimuli-responsive
self-immolative
polymers
(SIPs)
represent
a
unique
class
of
that
can
undergo
controlled,
sequential
head-to-tail
depolymerization
upon
specific
stimuli.
Since
their
inception,
they
have
evolved
over
two
decades
to
become
one
the
most
attractive
polymer
types.
With
characteristic
feature
"one
stimulus,
multiple
responses",
SIPs
inherently
possess
ability
serve
as
chemical
amplifiers,
which
amplify
weak
or
biological
signals.
This
promises
higher
stimulus
sensitivity,
greater
selectivity
for
microenvironments,
and
potential
generate
more
persistent,
extensive,
significant
responses
while
consuming
fewer
stimuli
sources.
Review
summarizes
latest
research
advancements
in
stimuli-responsive
drug
delivery
molecular
imaging
past
five
years.
Regarding
structure
SIPs,
we
briefly
overview
updates
self-immolation
units,
end-cap
moieties,
sequence
SIPs.
In
terms
applications,
focus
on
possible
applications
disease
treatment
methods.
Finally,
provide
brief
perspective
future
directions
these
applications.
Nano Letters,
Год журнала:
2024,
Номер
24(43), С. 13708 - 13717
Опубликована: Окт. 17, 2024
Reactive
oxygen
species
(ROS)-responsive
drug
delivery
systems
possess
immense
potential
for
targeted
and
controlled
release
of
therapeutics.
However,
the
rapid
responsiveness
to
ROS
sustained
antibacterial
drugs
are
often
limited
by
challenging
microenvironment
periodontitis.
Integrating
ROS-responsive
with
photocatalytic
technologies
presents
a
strategic
approach
overcome
these
limitations.
Herein,
pillararene-embedded
covalent
organic
framework
(PCOF)
incorporating
prodrug
thioacetal
(TA)
has
been
developed
treat
This
drug-loaded
nanoplatform,
namely
TA-loaded
PCOF,
utilizes
self-amplifying
property
enhance
therapeutic
efficacy.
PCOFs
demonstrate
exceptional
photosensitivity
generation
capabilities
when
employed
as
carriers.
When
exposed
ROS,
TA
within
nanoplatform
was
activated
cleaved
into
cinnamaldehyde
(CA),
highly
potent
compound.
By
leveraging
visible
light
activate
site-specific
infection
targeting,
PCOF
effectively
alleviated
periodontitis,
thereby
advancing
field
systems.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(28), С. 36142 - 36156
Опубликована: Июль 5, 2024
There
is
an
urgent
need
to
develop
phototherapeutic
agents
with
imaging
capabilities
assess
the
treatment
process
and
efficacy
in
real-time
during
cancer
phototherapy
for
precision
therapy.
The
safe
near-infrared
(NIR)
fluorescent
dyes
have
garnered
significant
attention
are
desirable
theranostics
agents.
However,
until
now,
achieving
excellent
photostability
fluorescence
(FL)
capability
aggregation-caused
quenching
(ACQ)
remains
a
big
challenge.
Here,
only
FDA-approved
NIR
dye,
indocyanine
green
(ICG),
we
developed
dual-ferrocene
(Fc)
chimeric
nanonetwork
ICG@HFFC
based
on
rigid-flexible
strategy
through
one-step
self-assembly,
which
uses
rigid
Fc-modified
hyaluronic
acid
(HA)
copolymer
(HA-Fc)
flexible
octadecylamine
(ODA)
bonded
Fc
(Fc-C
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 3, 2025
The
present
investigation
aims
to
develop
a
reactive
oxygen
species
(ROS)
and
esterase-responsive
biodegradable
mannosylated
polyurethane
effectively
deliver
the
encapsulated
antileishmanial
drug
amphotericin
B
(AmB)
selectively
infected
macrophage
cells.
Owing
suitable
amphiphilic
balance,
as-synthesized
glycosylated
(
Abstract
Theranostic
applications
in
atherosclerosis
plaque
microenvironment‐triggered
nanoplatforms
are
significantly
compromised
by
the
complex
synthesis
procedure,
non‐specific
distribution,
and
limited
therapeutic
function.
Therefore,
development
of
a
facile
feasible
method
to
construct
pathology‐based
stimuli‐responsive
nanoplatform
with
satisfactory
theranostic
performance
remains
demanding
highly
anticipated
goal.
Herein,
novel
class
multifunctional
supra‐carbon
dots
(CDs),
denoted
as
MM@Ce‐CDs
NPs,
simple
nanoassembly
subsequent
coating
macrophage
membrane
(MM),
is
developed
for
targeted
reactive
oxygen
species‐trigged
positive
regulation
pathological
microenvironment
AS.
The
harvested
NPs
exhibit
activatable
fluorescence
properties,
photoacoustic
characteristics,
cascade
enzyme
performances,
which
can
be
effectively
activated
under
ROS
stimulation
microenvironment,
enabling
precise
control
over
functions,
while
markedly
enhancing
diagnostic
accuracy
efficacy
AS
management.
Besides,
manipulate
reducing
levels
inflammation,
alleviating
M1
infiltration,
inhibiting
foam
cell
formation,
all
together
suppressing
through
synergistic
mechanisms.
In
addition,
inherit
biomimetic
biological
functions
from
MM,
facilitating
specific
target
delivery
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
For
efficient
anticancer
drug
delivery,
cascade
physiological
barriers
must
be
overcome,
which
requires
the
delivery
vehicles
to
possess
different
or
even
opposite
properties
at
stages.
Poly(tertiary
amine‐oxide)
(PTAO)
polymers
with
zwitterionic
feature
have
distinct
antifouling
in
blood
circulation,
can
reduced
and
protonated
hypoxic
tumors
promote
cellular
internalization.
Nevertheless,
effects
of
various
PTAO
structures
not
been
studied
systemically
optimized.
In
this
report,
side
groups
are
proposed
optimized
by
modulating
structures.
Poly(2‐(
N
‐oxide‐hexamethyleneimino)ethyl
methacrylate)
(POC7A)
a
cyclic
seven‐membered
ring
is
screened
as
structure
for
vivo
applications.
Moreover,
block
copolymer
POC7A‐block‐poly(
ε
‐caprolactone)
(POC7A‐PCL)
prepared
formation
micelles
aqueous
solution
doxorubicin
(DOX).
The
nature
POC7A
shells
bioreductive
activity
protonation
tumor
microenvironment
endows
excellent
long
accumulation,
deep
penetration,
effective
Thus,
DOX‐loaded
exhibit
potent
antitumor
efficacy
after
intravenous
administration.
Zwitterionic
used
nanocarriers
overcome
efficiently.
