Hydroalkylation of unactivated olefins with C(sp 3 )─H compounds enabled by NiH-catalyzed radical relay DOI Creative Commons

Jiang‐Ling Shi,

Youcheng Wang,

Yufeng Han

и другие.

Science Advances, Год журнала: 2024, Номер 10(51)

Опубликована: Дек. 18, 2024

The hydroalkylation reaction of olefins with alkanes is a highly desirable synthetic transformation toward the construction C(sp 3 )─C(sp ) bonds. However, such has proven to be challenging for unactivated olefins, particularly when substrates lack directing groups or acidic )─H Here, we address this challenge by merging NiH-catalyzed radical relay strategy HAT (hydrogen atom transfer) process. In catalytic system, nucleophilic alkyl generated from compound in presence promotor, which couples an metallic intermediate olefin substrate NiH catalyst form bond. Starting easily available materials, not only demonstrates wide functional group compatibility but also provides products regiodivergence and excellent enantioselectivity through effective control under mild conditions.

Язык: Английский

Hydroalkylation of unactivated olefins with C(sp 3 )─H compounds enabled by NiH-catalyzed radical relay DOI Creative Commons

Jiang‐Ling Shi,

Youcheng Wang,

Yufeng Han

и другие.

Science Advances, Год журнала: 2024, Номер 10(51)

Опубликована: Дек. 18, 2024

The hydroalkylation reaction of olefins with alkanes is a highly desirable synthetic transformation toward the construction C(sp 3 )─C(sp ) bonds. However, such has proven to be challenging for unactivated olefins, particularly when substrates lack directing groups or acidic )─H Here, we address this challenge by merging NiH-catalyzed radical relay strategy HAT (hydrogen atom transfer) process. In catalytic system, nucleophilic alkyl generated from compound in presence promotor, which couples an metallic intermediate olefin substrate NiH catalyst form bond. Starting easily available materials, not only demonstrates wide functional group compatibility but also provides products regiodivergence and excellent enantioselectivity through effective control under mild conditions.

Язык: Английский

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