Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
clinically
approved
therapeutic
modality
that
has
shown
great
potential
for
cancer
treatment.
However,
there
exist
two
major
problems
hindering
PDT
applications:
the
nonspecific
phototoxicity
requiring
patients
to
stay
in
dark
post‐PDT,
and
limited
photodynamic
efficiency.
Herein,
we
report
photo‐triggered
porphyrin
polyelectrolyte
nanoassembling
(photo‐triggered
PPN)
strategy,
which
photosensitizer
photoswitchable
energy
accepter
are
assembled
into
micelles
by
combined
force
of
charge
interaction
metal‐ligand
coordination.
The
polyelectrolyte‐based
PPN
exhibits
good
biocompatibility,
bestows
unique
“confining
isolated”
inner
microenvironment
fully
overcoming
π–π
stacking
porphyrins
with
significant
efficiency
(123‐fold
enhancement).
Due
high
Förster
resonance
transfer
(FRET)
(91.5
%)
between
photoswitch
closed‐form,
could
use
light
as
specific
trigger
modulate
closed‐
open‐form,
manipulate
1
O
2
generation
three
stages:
pre‐PDT
(quenching
generation),
during
(activating
post‐PDT
(silencing
generation).
This
de
novo
strategy
first
time
realized
remotely
manipulating
boosting
PDT,
well
resolving
critical
general
challenges
side
effects
from
phototoxicity.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 4, 2025
Abstract
Type‐I
photosensitizers
(PSs)
are
considered
to
be
efficient
agents
for
overcoming
the
oxygen‐dependent
deficiency
of
traditional
photodynamic
therapy
(PDT).
However,
it
is
still
challenging
design
type‐I
PSs
that
can
activated
by
second
near‐infrared
(NIR‐II)
irradiation.
Herein,
a
series
organic
heavy‐atom‐free
molecules
designed
(named
as
CTU1
,
CTU2
and
CTU3
)
exhibit
strong
absorption
bands
over
first
NIR‐II
regions.
Among
them,
water‐dispersible
nanoparticles
(NPs)
show
J
‐aggregate
characteristics
good
band,
resulting
in
highly
•O
2
−
generation
upon
irradiation
1064
nm
light.
In
addition,
NPs
also
high
photothermal
conversion
efficiency
88.6%.
vitro
vivo
experiments
have
superior
PDT
(PTT)
effects,
which
further
induce
immunogenic
cell
death
activate
immune
cells
4T1
tumor‐bearing
mice
combined
PDT/PTT
anti‐tumor
photoimmunotherapy
against
refractory
tumors.
This
work
presents
paradigm
de
novo
light‐activated
PS
combinational
cancer.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Photodynamic
therapy
(PDT)
is
a
clinically
approved
therapeutic
modality
that
has
shown
great
potential
for
cancer
treatment.
However,
there
exist
two
major
problems
hindering
PDT
applications:
the
nonspecific
phototoxicity
requiring
patients
to
stay
in
dark
post-PDT,
and
limited
photodynamic
efficiency.
Herein,
we
report
photo-triggered
porphyrin
polyelectrolyte
nanoassembling
(photo-triggered
PPN)
strategy,
which
photosensitizer
photoswitchable
energy
accepter
are
assembled
into
micelles
by
combined
force
of
charge
interaction
metal-ligand
coordination.
The
polyelectrolyte-based
PPN
exhibits
good
biocompatibility,
bestows
unique
"confining
isolated"
inner
microenvironment
fully
overcoming
π-π
stacking
porphyrins
with
significant
efficiency
(123-fold
enhancement).
Due
high
Förster
resonance
transfer
(FRET)
(91.5
%)
between
photoswitch
closed-form,
could
use
light
as
specific
trigger
modulate
closed-
open-form,
manipulate
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Дек. 4, 2024
Redox
balance
is
essential
for
sustaining
normal
physiological
metabolic
activities
of
life.
In
this
study,
we
present
a
photocatalytic
system
to
perturb
the
NADH/NAD+
in
oxygen-free
conditions,
achieving
therapy
cure
anaerobic
bacterial
infected
periodontitis.
Under
light
irradiation,
catalyst
TBSMSPy+
can
bind
DNA
and
initiate
generation
radical
species
through
multi-step
electron
transfer
process.
It
catalyzes
conversion
from
NADH
NAD+
(the
turnover
frequency
up
60.7
min−1),
inhibits
ATP
synthesis,
disrupts
energy
supply
required
replication,
successfully
accomplishes
sterilization
an
environment.
The
participates
redox
reaction,
interfering
with
contents
under
so
termed
action
as
photoinduced
imbalance.
Additionally,
animal
experiments
male
rats
also
validate
that
could
effectively
catalyze
oxidation,
suppress
metabolism
stimulate
osteogenesis.
Our
research
substantiates
concept
imbalance
application
therapy,
further
advocating
development
such
based
on
strategy
phototherapy.
Disturbing
bacteria
presents
promising
but
underdeveloped
treatment
difficult-to-cure
diseases
caused
by
bacteria.
Here,
authors
report
treat
JOURNAL OF SURGICAL AND CLINICAL RESEARCH,
Год журнала:
2024,
Номер
15(1), С. 59 - 78
Опубликована: Июль 8, 2024
The
integration
of
nanotechnology
and
immune
therapy
presents
a
revolutionary
approach
to
cancer
treatment,
merging
the
precision
nanoscale
engineering
with
power
system
combat
malignancies.
This
review
article
explores
synergy
between
therapy,
highlighting
its
potential
enhance
antineoplastic
efficiency
mitigate
hepatotoxicity,
particular
focus
on
liver
treatments.
Nanotechnology
offers
novel
solutions
for
targeted
drug
delivery,
controlled
release,
co-delivery
therapeutic
agents,
thus
improving
bioavailability
efficacy
therapies.
By
overcoming
challenges
posed
by
immunosuppressive
tumor
microenvironment
(TME),
nanotechnology-enabled
strategies
can
potentiate
antitumor
response
transform
"cold"
tumors
into
"hot"
ones,
making
them
more
amenable
immune-mediated
destruction.
Despite
promising
advancements,
field
faces
such
as
optimizing
nanoparticle
formulations
maximal
safety,
identifying
suitable
targeting
ligands
specific
types,
addressing
heterogeneity
TME.
Comprehensive
preclinical
clinical
studies
are
required
assess
biodistribution,
metabolism,
toxicity
nanocarriers.
underscores
transformative
combining
offering
insights
future
directions
effective,
targeted,
safer
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
clinically
approved
therapeutic
modality
that
has
shown
great
potential
for
cancer
treatment.
However,
there
exist
two
major
problems
hindering
PDT
applications:
the
nonspecific
phototoxicity
requiring
patients
to
stay
in
dark
post‐PDT,
and
limited
photodynamic
efficiency.
Herein,
we
report
photo‐triggered
porphyrin
polyelectrolyte
nanoassembling
(photo‐triggered
PPN)
strategy,
which
photosensitizer
photoswitchable
energy
accepter
are
assembled
into
micelles
by
combined
force
of
charge
interaction
metal‐ligand
coordination.
The
polyelectrolyte‐based
PPN
exhibits
good
biocompatibility,
bestows
unique
“confining
isolated”
inner
microenvironment
fully
overcoming
π–π
stacking
porphyrins
with
significant
efficiency
(123‐fold
enhancement).
Due
high
Förster
resonance
transfer
(FRET)
(91.5
%)
between
photoswitch
closed‐form,
could
use
light
as
specific
trigger
modulate
closed‐
open‐form,
manipulate
1
O
2
generation
three
stages:
pre‐PDT
(quenching
generation),
during
(activating
post‐PDT
(silencing
generation).
This
de
novo
strategy
first
time
realized
remotely
manipulating
boosting
PDT,
well
resolving
critical
general
challenges
side
effects
from
phototoxicity.
