Abstract
Elevated
levels
of
reactive
oxygen
species
(ROS)
are
a
hallmark
varieties
diseases
such
as
cancer,
inflammation,
and
neurodegenerative
disorders.
Inspired
by
the
discrepancy
ROS
concentrations
between
pathological
tissues
normal
counterparts,
an
increasing
number
ROS‐responsive
theragnostic
prodrugs
developed
in
past
years,
with
particularly
high
proportions
organoboron‐based
that
can
respond
to
H
2
O
.
Unfortunately,
studies
have
demonstrated
intrinsic
(H
)
most
tissue
only
slightly
higher
than
not
adequate
activate
organoboron
prodrugs;
contrast,
several
compounds
been
clinically
approved
which
boronic
acid
acts
electrophilic
warhead.
To
this
end,
developing
more
robust
universal
approaches
for
acid‐prodrug
activation
becomes
highly
attractive.
In
context,
we
discuss
recently
reported
strategies
boron‐caged
particular
focus
on
their
design
principles
mechanisms.
The
perspectives
future
directions
important
research
area
discussed
well.
Angewandte Chemie,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 1, 2025
Abstract
In
a
recent
communication,
Collins
and
coworkers
presented
Cu(I)
complex
with
photocatalytic
activity
under
red
light
LED
conditions,
mainly
for
singlet
oxygen‐driven
reactions.
Guided
by
steady‐state
emission
measurements
800
nm
excitation,
the
authors
suggested
that
underlying
mechanism
generation
of
photoexcited
key
species
is
simultaneous
two‐photon
absorption
via
virtual
state.
However,
such
requires
pulsed
laser
excitation
cannot
compete
when
conventional
one‐photon
also
feasible
selected
wavelength
range.
Using
several
spectroscopic
techniques
reactivity
assays
different
color
intensity
we
unambiguously
demonstrate
followed
rather
inefficient
oxygen
(quantum
yield
<5%)
responsible
observed
photoreactivity
complex.
addition,
briefly
summarize
general
mechanistic
considerations,
estimate
typical
photon
densities
required
variety
mechanisms,
highlight
importance
optical
filters
impurities
to
avoid
artifacts
in
spectra,
present
some
guidelines
differentiation
between
one‐
mechanisms.
Organic Letters,
Год журнала:
2024,
Номер
26(37), С. 7976 - 7980
Опубликована: Сен. 6, 2024
The
use
of
an
earth-abundant
and
inexpensive
iron
complex
as
a
catalyst,
coupled
with
near-infrared
(NIR)
light
the
energy
source,
for
radical
reactions
alkyl
halides
has
been
far
less
developed.
In
this
study,
we
report
NIR
light-mediated
iron(I)
dimer-catalyzed
cascade
fluoroalkyl
bromides
synthesis
ring-fused
quinazolinones
bearing
difluoromethyl
group.
process,
3-bromo-1,10-phenanthroline
ligand
facilitates
reactivity
[CpFe(CO)
Abstract
A
novel
bifunctional
photocatalyst
combining
an
aza-BODIPY
and
a
chiral
oxazoline
has
been
developed.
This
enables
the
asymmetric
hydroxylation
of
β‑ketoesters
under
oxygen
atmosphere
irradiation
with
18-W
red
LEDs.
procedure
offers
convenient
potentially
general
approach
to
obtain
enantioenriched
α-hydroxy-β-dicarbonyl
products.
The
results
reported
in
this
manuscript
demonstrate
promise
new
organic
design
will
help
expand
application
BODIPY-based
photocatalysts.
Abstract
Elevated
levels
of
reactive
oxygen
species
(ROS)
are
a
hallmark
varieties
diseases
such
as
cancer,
inflammation,
and
neurodegenerative
disorders.
Inspired
by
the
discrepancy
ROS
concentrations
between
pathological
tissues
normal
counterparts,
an
increasing
number
ROS‐responsive
theragnostic
prodrugs
developed
in
past
years,
with
particularly
high
proportions
organoboron‐based
that
can
respond
to
H
2
O
.
Unfortunately,
studies
have
demonstrated
intrinsic
(H
)
most
tissue
only
slightly
higher
than
not
adequate
activate
organoboron
prodrugs;
contrast,
several
compounds
been
clinically
approved
which
boronic
acid
acts
electrophilic
warhead.
To
this
end,
developing
more
robust
universal
approaches
for
acid‐prodrug
activation
becomes
highly
attractive.
In
context,
we
discuss
recently
reported
strategies
boron‐caged
particular
focus
on
their
design
principles
mechanisms.
The
perspectives
future
directions
important
research
area
discussed
well.
