Surface Topological Glycosylation‐Mediated Mucoadhesion of Bacteria^†

Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(13), С. 1447 - 1455

Опубликована: Март 13, 2024

Comprehensive Summary Sugar moieties present on bacterial surface serve as pivotal regulators of activity. Precisely adjusting the abundance and distribution sugar can offer an important approach to manipulating behavior, but has been proven be difficult. Herein, topological glycosylation is reported mediate interaction bacteria with mucous layer. Alkynes functionalized by different branching are synthesized through iterative Michael addition amide condensation reactions. By a copper‐catalyzed azide‐alkyne cycloaddition, resulting compounds structures attached onto that modified azido groups. As proof‐of‐concept study, set topologically glycosylated probiotics (TGPs) prepared using linear, two‐branched, tetra‐branched compounds, respectively. The between mucin TGPs was studied results demonstrate that, compared unmodified bacteria, exhibit enhanced adhesive capacity mucin, which increases numbers. Similar binding trend observed in ex vivo colonic mucus adhesion experiments display highest efficiency. This work proposes chemical method tune providing unique significant insights into manipulation behavior modification.

Язык: Английский

---

Coated Bacteria: Advanced Living Materials for Microbial Therapy

Accounts of Materials Research, Год журнала: 2024, Номер 5(7), С. 872 - 883

Опубликована: Июнь 24, 2024

ConspectusLiving materials represent an emerging and innovative concept at the forefronts of science due to distinctive living characteristics. Living organisms, such as microorganisms, plant cells, mammalian have been used major elements for fabrication materials. Given favorable features including reproductivity, genetic modifiability, adaptability, cultivability, bacteria received increasing attention development engineered Particularly, owing inherent abilities target colonize specific in vivo sites, activate immune responses, inhibit pathogens, play key roles maintaining human health currently widely exploited preparation therapeutic agents. However, caused by innate immunogenicity, metabolic activity, movability, use bacteria-based applications often suffers from poor biosafety insufficient bioavailability, inevitably resulting low treatment efficacy. In order address these challenges, extensive efforts invested designing engineering various advanced generate superior agents using modification surface decoration.In this Account, we summarize recent advances our group with a focus on coating material microbial therapy. First, present brief introduction existing nature that possess characteristics reproduction, biosynthesis, self-healing, self-organization, self-adaption, environment responsiveness, particular emphasis advantages composed Second, elaborate current challenges then showcase strategies prepare bacterial therapeutics individual bacteria. Three types are included Account: (1) physical strategy coat eukaryotic cell membranes red blood cells yeast mechanical extrusion; (2) chemical wrap synthetic coatings interfacial self-assembly mineralization; (3) biological encapsulate self-secreted biofilms apoptosis bodies through external stimulations. We highlight coated can be endowed wide range coating-derived exogenous functions enumerate their appealing reduced clearance, increased improved safety, preferential colonization vivo. Third, shift potential treating diseases, especially different cancer intestinal inflammations. Lastly, discuss remaining need addressed further clinic practice outlooks preparing next-generation well future bench bedside translation. anticipate Account offer valuable insights generation therapy encourage ideas new initiatives expand preventing diseases.

Язык: Английский

---

Advanced Bioinspired Multifunctional Platforms Focusing on Gut Microbiota Regulation

ACS Nano, Год журнала: 2024, Номер 18(32), С. 20886 - 20933

Опубликована: Июль 31, 2024

Gut microbiota plays a crucial role in maintaining host homeostasis, impacting the progression and therapeutic outcomes of diseases, including inflammatory bowel disease, cancer, hepatic conditions, obesity, cardiovascular pathologies, neurologic disorders, via immune, neural, metabolic mechanisms. Hence, gut is promising target for disease therapy. The safety precision traditional regulation methods remain challenge, which limits their widespread clinical application. This limitation has catalyzed shift toward development multifunctional delivery systems that are predicated on modulation. Guided by bioinspired strategies, an extensive variety naturally occurring materials mechanisms have been emulated harnessed construction platforms aimed at monitoring modulation microbiota. review outlines strategies advantages utilizing principles design intervention based methods. Representative studies summarized, to confer multiple pharmacological benefits synergistic management diseases. prospective avenues inherent challenges associated with adoption refinement proposed augment efficacy treatment.

Язык: Английский

---

Multifunctional nanoparticles confers both multiple inflammatory mediators scavenging and macrophage polarization for sepsis therapy

Materials Today Bio, Год журнала: 2024, Номер unknown, С. 101421 - 101421

Опубликована: Дек. 1, 2024

Язык: Английский

---

Acetal‐thiol Click‐like Reaction: Facile and Efficient Synthesis of Dynamic Dithioacetals and Recyclable Polydithioacetals

Angewandte Chemie, Год журнала: 2024, Номер 136(31)

Опубликована: Май 20, 2024

Abstract Dithioacetals are heavily used in organic, material and medical chemistries, exhibit huge potential to synthesize degradable or recyclable polymers. However, the current synthetic approaches of dithioacetals polydithioacetals overwhelmingly dependent on external catalysts organic solvents. Herein, we disclose a catalyst‐ solvent‐free acetal‐thiol click‐like reaction for synthesizing polydithioacetals. High conversion, higher than acid catalytic reaction, can be achieved. universality was confirmed by monitoring reactions linear cyclic acetals (including renewable bio‐sourced furan‐acetal) with aliphatic aromatic thiols, mechanism monomolecular nucleophilic substitution (S N 1) auto‐protonation (activation) thiol clarified combining experiments density functional theory computation. Subsequently, utilize this readily By simple heating stirring, w ~110 kDa were synthesized from acetal dithiol, depolymerization into macrocyclic dithioacetal repolymerization polydithioacetal achieved; through reactive extrusion, semi‐interpenetrating polymer dynamic network excellent mechanical properties continuous reprocessability prepared poly(vinyl butyral) pentaerythritol tetrakis(3‐mercaptopropionate). This green high‐efficient synthesis method is beneficial sustainable development chemistry.

Язык: Английский

---