Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 2, 2024
Comprehensive
Summary
Enhancing
the
DNA
toolbox
with
innovative
photochemical
reactions
is
pivotal
for
advancing
nucleic
acid‐based
technologies.
Aldehyde
groups,
versatile
bioorthogonal
handles
imine
formation
under
acidic
conditions,
are
particularly
valuable
due
to
their
roles
in
acid
epigenetics.
Here,
we
present
first
photocatalytic
on‐DNA
aldehyde
allylation,
enabling
precise
functionalization
mild,
neutral
aqueous
conditions.
Our
approach
utilizes
a
polarity‐reversal
reaction
between
DNA‐conjugated
benzaldehydes
and
allyl
sulfones.
This
demonstrates
exceptional
chemoselectivity
while
preserving
integrity.
By
varying
sulfones,
achieve
site‐specific
labeling
of
non‐native
group
cross‐linking
DNA‐bearing
Furthermore,
our
method
facilitates
selective
pull‐down
enrichment
5‐formylpyrimidine
nucleotides
among
complex
cellular
DNA.
transformation
expands
limited
toolboxes,
providing
novel
avenues
functionalizing
both
native
modifications
on
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Derivatising
biomolecules
like
monoclonal
antibodies
with
drugs
or
imaging
agents,
whilst
preserving
their
bioactivity,
is
a
challenging
task.
Photochemistry
offers
new
solutions
for
protein
functionalisation.
Organic Letters,
Год журнала:
2024,
Номер
26(5), С. 1094 - 1099
Опубликована: Янв. 26, 2024
Utilizing
already
existing
DNA-encoded
libraries
(DELs)
for
the
generation
of
a
distinct
DEL
represents
an
expedited
strategy
expanding
chemical
space.
Herein,
we
leverage
unique
photoreactivity
tetrazoles
to
synthesize
diacylhydrazines
on
DNA.
Widely
available
carboxylic
acids
serving
as
building
blocks
were
employed
under
mild
photomediated
reaction
conditions,
affording
diverse
DNA-conjugated
diacylhydrazines.
This
methodology
also
demonstrates
robustness
in
DEL-compatible
synthesis
and
facilitates
preparation
oligonucleotide-based
probes.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(10), С. 2851 - 2856
Опубликована: Янв. 1, 2024
K
2
RuO
4
-mediated
oxidation
offers
a
DNA-compatible
method
for
functional
group
transformations,
enabling
alcohol-to-carboxylic
acid
and
amine-to-nitrile
conversions
valuable
DNA-encoded
library
synthesis.
Expert Opinion on Drug Discovery,
Год журнала:
2024,
Номер
19(6), С. 725 - 740
Опубликована: Май 16, 2024
Introduction
The
effectiveness
of
Fragment-based
drug
design
(FBDD)
for
targeting
challenging
therapeutic
targets
has
been
hindered
by
two
factors:
the
small
library
size
and
complexity
fragment-to-hit
optimization
process.
DNA-encoded
(DEL)
technology
offers
a
compelling
robust
high-throughput
selection
approach
to
potentially
address
these
limitations.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
Chemical
reactions
underpin
biological
processes,
and
imbalances
in
critical
biochemical
pathways
within
organisms
can
lead
to
the
onset
of
severe
diseases.
Within
this
context,
emerging
field
“Nanocatalytic
Medicine”
leverages
nanomaterials
as
catalysts
modulate
fundamental
chemical
specific
microenvironments
This
approach
is
designed
facilitate
targeted
synthesis
localized
accumulation
therapeutic
agents,
thus
enhancing
treatment
efficacy
precision
while
simultaneously
reducing
systemic
side
effects.
The
effectiveness
these
nanocatalytic
strategies
critically
hinges
on
a
profound
understanding
kinetics
intricate
interplay
particular
pathological
ensure
effective
catalytic
actions.
review
methodically
explores
situ
their
associated
biomaterials,
emphasizing
regulatory
that
control
responses.
Furthermore,
discussion
encapsulates
crucial
elements‐reactants,
catalysts,
reaction
conditions/environments‐necessary
for
optimizing
thermodynamics
reactions,
rigorously
addressing
both
biophysical
dimensions
disease
enhance
outcomes.
It
seeks
clarify
mechanisms
underpinning
biomaterials
evaluate
potential
revolutionize
across
various
conditions.
Chemical Communications,
Год журнала:
2024,
Номер
60(59), С. 7638 - 7641
Опубликована: Янв. 1, 2024
DNA-compatible
diversity-oriented
synthesis
of
nitrogen-containing
heterocycles
via
the
in
situ
conversion
primary
amines
into
versatile
isothiocyanates
intermediates.
Bioconjugate Chemistry,
Год журнала:
2024,
Номер
35(8), С. 1251 - 1257
Опубликована: Авг. 8, 2024
The
DNA-encoded
library
(DEL)
is
a
robust
tool
for
chemical
biology
and
drug
discovery.
In
this
study,
we
developed
DNA-compatible
light-promoted
reaction
that
highly
efficient
plate-compatible
DEL
construction
based
on
the
formation
of
indazolone
scaffold.
Employing
high-efficiency
approach,
constructed
featuring
an
core,
which
enabled
identification
novel
series
ligands
specifically
targeting
E1A-binding
protein
(p300)
after
selection.
Taken
together,
our
findings
underscore
feasibility
reactions
in
synthesis
unveil
promising
avenues
developing
p300-targeting
inhibitors.
Thiohydantoin
represents
a
significant
class
of
biologically
active
privileged
heterocyclic
scaffolds.
Herein,
we
present
convenient
and
robust
DNA-compatible
method
for
constructing
thiohydantoin-focused
DNA-encoded
library.
This
reaction
can
be
applied
to
wide
variety
isothiocyanate
partners,
arylamine
feedstocks,
diverse
α-amine
acid
derivatives,
exhibiting
excellent
conversions,
high
functional
group
tolerance,
preservation
DNA
tag
integrity.
Our
allows
easy
access
valuable
three-cycle
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Synthesis
of
chemically
diverse
heterocyclic
scaffolds
in
DNA-encoded
libraries
is
highly
demanded.
We
herein
reported
a
convenient
one-pot
multi-component
on-DNA
synthetic
strategy
to
afford
multi-substituted
2,3-dihydrofuran
via
pyridinium
ylide-mediated
cyclization.
This
reaction
exhibited
modest
excellent
conversions
for
broad
range
DNA-conjugated
aldehydes,
β-ketonitriles
and
salts
under
mild
conditions.
Furthermore,
the
compatibility
this
with
DEL
construction
was
verified
by
enzymatic
DNA
ligation,
PCR
amplification
mock
library
synthesis.
