Room-Temperature Rh(I)-Catalyzed P(III)-Directed C–H Bond Alkylation: Enhanced Reactivity through Ligand Acceleration

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 2839 - 2846

Опубликована: Фев. 2, 2025

Язык: Английский

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P(═O)R₂-Directed Asymmetric Catalytic C–H Olefination Leading to C–N Axially Chiral Targets

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

A novel P(═O)R2-directed asymmetric catalytic olefination has been developed, enabling efficient access to carbon–nitrogen axially chiral products with excellent yields (up 92%) and enantioselectivity 99% enantiomeric excess). The synergistic coordination of phosphine oxide functionality l-pGlu-OH the Pd metal center, serving as an directing group ligand, was key success this C–H functionalization system. reaction demonstrated a broad substrate scope, yielding 33 distinct C–N axial products. absolute configuration unambiguously confirmed via X-ray diffraction analysis. Additionally, three representative applications were showcased, involving reduction oxidation produce phosphines related derivatives. plausible cycle mechanism proposed, supported by detailed experimental studies. Aggregates in system identified aggregation-induced polarization experiments.

Язык: Английский

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N-Heterocyclic Carbene-Catalyzed Chemo- and Enantioselective Three-Component Esterification/Amidation Relay for Access to Planar Chiral Ferrocene Derivatives

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 6130 - 6140

Опубликована: Апрель 1, 2025

Язык: Английский

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Synthesis of Planar Chiral Ferrocenes by Catalytic Desymmetrization Reactions

ChemCatChem, Год журнала: 2024, Номер unknown

Опубликована: Июнь 6, 2024

Abstract Since its discovery in the early 1950s, sandwich‐type structure of ferrocene has sparked significant research into applications across various disciplines, including asymmetric synthesis, medicinal chemistry, and materials science. Planar chiral ferrocenes play a crucial role catalysis by serving as essential scaffolds for ligands catalysts. Classical methods synthesizing planar often encounter limitations such low atom economy lengthy synthesis steps. In contrast, catalytic desymmetrization strategies offer promising alternative due to their ability enhance step efficiency. This review highlights recent advancements this field, particularly focusing on transition‐metal‐catalyzed C−H functionalization enantioselective reactions.

Язык: Английский

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Palladium-Catalyzed Dual C–H Arylation/Cyclization Reaction of Iodoferrocenes with ortho-Bromobenzamides for the Construction of Arylated Isoquinolone-Fused Ferrocenes

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

We reported a palladium/norbornene-catalyzed dual intermolecular C-H arylation/intramolecular cyclization reaction of iodoferrocenes with

Язык: Английский

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Substrate NOBINAc ligand affinity for Pd^II-catalyzed enantioselective C–H activation over reactive β-C–H bonds in ferrocenyl amines

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Ferrocenyl amines as directing groups for C–H activation have limitations they are prone to undergo oxidation, allylic deamination, and β-hydride elimination.

Язык: Английский

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An innovative C–H arylation strategy to make chiral phosphines

Trends in Chemistry, Год журнала: 2024, Номер 6(6), С. 332 - 333

Опубликована: Май 10, 2024

Язык: Английский

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P(III)-Directed Asymmetric C—H Arylation toward Planar Chiral Ferrocenes by Palladium Catalysis

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(5), С. 1693 - 1693

Опубликована: Янв. 1, 2024

Язык: Английский

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Three-component tandem remote C-H functionalization of naphthalenes by ruthenium catalysis: Modular and concise synthesis of multifunctional naphthalenes

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

A versatile multi-component strategy for synthesizing multi-functional naphthalenes via ruthenium-catalyzed tandem C5–H functionalization from readily available naphthalene, olefin and alkyl bromide compounds is disclosed.

Язык: Английский

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