Nickel-Catalyzed Three-Component Carboamination/Cyclization of Alkynes To Access 2,3-Disubstituted Quinolines
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Presented
herein
is
a
nickel-catalyzed
chemo-
and
regioselective
three-component
tandem
carboamination
cyclization
of
terminal
alkynes
with
organoboronic
acids
anthranils
for
facile
modular
access
to
2,3-substituted
quinolines.
In
this
process,
anthranil
has
dual
roles:
serving
as
an
electrophilic
aminating
reagent
redox
buffer
suppress
the
generation
off-cycle
Ni(0)
complex.
Moreover,
anionic
acetylacetonate
(acac)
ligand
was
found
be
vital
ensure
productive
Ni(I)-Ni(III)-Ni(I)
catalytic
cycle.
Язык: Английский
Nickel-Catalyzed, Aminoquinoline-Directed Chemo- and Regioselective Carboamination of Unactivated Olefins with Organoboronic Acids and Anthranils
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 19, 2024
A
nickel-catalyzed
three-component
carboamination
of
unactivated
alkenes
with
organoboronic
acids
and
anthranils
has
been
achieved
for
the
expedient
synthesis
δ-aryl
γ-amino
acid
derivatives.
The
8-aminoquinoline
(AQ)
directing
group
is
crucial
success
reaction,
anthranil
serves
as
an
arylnitrene
precursor
in
this
conversion.
This
method
features
mild
reaction
conditions,
good
chemo-
regioselectivity,
a
broad
substrate
scope
functional
tolerance.
Язык: Английский