Recent Natural Product Total Syntheses Involving Cycloadditions of Allenes

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Comprehensive Summary Allenes, characterized by their cumulated carbon–carbon double bonds, have emerged as indispensable synthons in the construction of complex natural products. Their unique reactivity and stereochemical properties render allenes a powerful tool for efficient streamlined total synthesis structurally intricate This review comprehensively summarizes syntheses products involving allene cycloaddition reactions reported over past decade (2014—2024). Among nearly 20 reviewed, [2+1], [2+2], [3+2], [4+2], [4+3], [5+1] [2+2+1] are most important transformations to construct key skeleton. is because ability form multiple bonds single step with high atom economy, stereoselectivity, regioselectivity, often under mild conditions. The strategic application these forming controlling stereochemistry makes them practical assembly molecular frameworks. With ongoing exploration methods generation, particularly enantioselective approaches, continued discovery novel cyclization allenes, chemistry will maintain its crucial role Key Scientists

Язык: Английский

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Concise syntheses of (+)-maximumins B and C and (+)-ottensinin

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(18), С. 5160 - 5166

Опубликована: Янв. 1, 2024

Three rearranged labdane diterpenoids, featuring a common 3-substituted γ-pyrone, were effectively synthesized with the longest linear sequences of 4–12 steps. The in-depth pharmacological screening unveiled (+)-ottensinin as potent KCNQ2 agonist.

Язык: Английский

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Synthesis of (–)-Higginsianin A

Synfacts, Год журнала: 2024, Номер 20(06), С. 0565 - 0565

Опубликована: Май 14, 2024

Key words (–)-higginsianin A - meroterpenoid Barton–McCombie deoxygenation C–H alkynylation Crabbé homologation allene hydroalkoxylation

Язык: Английский

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