On-Demand Photoactivation of DNA-Based Motor Motion

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

A major challenge in the field of synthetic motors relates to mimicking precise, on-demand motion biological motor proteins, which mediates processes such as cargo transport, cell locomotion, and division. To address this challenge, we developed a system control DNA-based using light. DNA are composed central chassis particle modified with "legs" that hybridize RNA "fuel", move upon enzymatic consumption RNA. We first concealed fuel sites photocleavable oligonucleotides block leg binding. Upon UV activation, blocking strands dissociate, exposing initiating active, directional motion. also created "brake" stalling strands, anchoring until light removes while simultaneously "fueling" motors, spatiotemporally controlled stop → go Additionally, activate via chemical input, an optical input is required motors. This dual-input approach, functioning "AND" gate, demonstrates potential for perform light-triggered computational tasks. Our work provides proof concept enhancing complexity functionality

Язык: Английский

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Nano-/Microrobots for Environmental Remediation in the Eyes of Nanoarchitectonics:

Research, Год журнала: 2025, Номер 8

Опубликована: Янв. 1, 2025

Nano-/microrobots have been demonstrated as an efficient solution for environmental remediation. Their strength lies in their propulsion abilities that allow active “on-the-fly” operation, such pollutant detection, capture, transport, degradation, and disruption. Another advantage is versatility, which allows the engineering of highly functional solutions a specific application. However, latter can bring complexity to applications; versatility dimensionality, morphology, materials, surface decorations, other modifications has crucial effect on resulting abilities, compatibility with environment, overall functionality. Synergy between decorations its projection functionality object nanoarchitectonics. Here, we scrutinize nano-/microrobots eyes nanoarchitectonics: list general concepts help assess synergy limitations individual procedures fabrication processes operation at macroscale. The nanoarchitectonics approached from microscopic level, focusing dimensionality through nanoscopic evaluating influence decoration nanoparticles quantum dots, moving molecular single-atomic level very fine tuning presented review aims lay provide overview advanced nano-/microrobot remediation beyond.

Язык: Английский

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Janus Polymeric Giant Vesicles on Demand: A Predictive Phase Separation Approach for Efficient Formation

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Janus particles, with their intrinsic asymmetry, are attracting major interest in various applications, including emulsion stabilization, micro/nanomotors, imaging, and drug delivery. In this context, polymersomes particularly attractive for synthetic cell development delivery systems. While they can be achieved by inducing a phase separation within membrane, fabrication method remains largely empirical. Here, we propose rational approach, using Flory–Huggins theory, to predict the self-assembly of amphiphilic block copolymers into asymmetric polymersomes. Our predictions experimentally validated forming highly stable giant unilamellar vesicles (JGUVs) remarkable yield exceeding 90% obtained from electroformation biocompatible copolymers. We also present general diagram correlating mixing energy polymersome morphology, offering valuable tool JGUV design. These extruded achieve quasi-monodisperse while maintaining Janus-like paving way functionalization use as active carriers.

Язык: Английский

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Magnetically Propelled Microrobots toward Photosynthesis of Green Ammonia from Nitrates

Small, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Ammonia (NH₃) production is a critical industrial process, as ammonia key component in fertilizers, essential for global agriculture and food production. However, the current method of synthesizing ammonia, Haber-Bosch highly energy-intensive, relies on fossil fuels, contributing substantially to greenhouse gas emissions. Moreover, centralized nature process limits its accessibility remote or resource-limited areas. Photochemical synthesis provides an alternate lower energy, carbon-free pathway compared prevailing methods. The photoconversion nitrate anions, often present wastewater, offers greener, more sustainable, energy-efficient route both ammonia-generation wastewater treatment. chemical requires intensive mass-transfer processes, which efficiency method. To change game, this work, new technology ammonia-generation, catalytic generation (AmmoGen) microrobot, converts using renewable light energy reported. magnetic propulsion AmmoGen microrobots significantly enhances mass-transfer, expedites photosynthesis ammonia. Overall, "proof-of-concept" study demonstrates that can aid small molecule activation value-added products; are envisaged pave way toward sustainable technologies catalysis.

Язык: Английский

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Visualization of Biomolecular Radiation Damage at the Single-Particle Level Using Lanthanide-Sensitized DNA Origami

Nano Letters, Год журнала: 2024, Номер 24(37), С. 11690 - 11696

Опубликована: Сен. 3, 2024

Precise monitoring of biomolecular radiation damage is crucial for understanding X-ray-induced cell injury and improving the accuracy clinical radiotherapy. We present design performance lanthanide-DNA-origami nanodosimeters directly visualizing at single-particle level. Lanthanide ions (Tb

Язык: Английский

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Construction of a precise temperature–controlled continuous-flow catalytic reactor based on cellulose and MXene with directional thermal pathway heating and enzyme immobilization

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158971 - 158971

Опубликована: Дек. 1, 2024

Язык: Английский

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