Molecular endoperoxides for optical imaging and photodynamic therapy

Coordination Chemistry Reviews, Год журнала: 2024, Номер 523, С. 216258 - 216258

Опубликована: Окт. 4, 2024

Язык: Английский

---

AIE and ICT Synergistic Lysosome-Targeted Ratiometric Fluorescence Sensor for the Detection and Imaging of Th⁴⁺ in the Liver of Zebrafish and Mice

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

The sensitive detection of the radioactive thorium (Th) ion with an oxidation state +4 (Th4+) is great significance for environmental protection and life safety. In this study, five fluorescence sensors regulated donor-acceptor (D-A) interactions were constructed Th4+ based on intramolecular charge transfer aggregation-induced emission mechanisms. Among developed sensors, TPE-D bearing electron-deficient π-bridge weak D-A presented ratiometric behavior toward in aqueous solution due to its characteristics unique D-A-D structures. Moreover, showed excellent selectivity sensitivity detection, limit was as low 8.1 × 10-8 M. sensing mechanism observation revealed that could coordinate hydroxyl, imine, carbonyl groups accompanied by electron process. addition, selectively be enriched lysosome. Both lysosome liver mice zebrafish realized strategy, a mobile-assisted approach actual water samples also established high sensitivity. This first report organelles organs, which provides reliable strategy radionuclide toxicology analysis applications.

Язык: Английский

---

Detecting Changes in Singlet Oxygen and Viscosity during Apoptosis-Ferroptosis Mediated Photodynamic Therapy and Establishing Visual Imaging of Fatty Liver

ACS Sensors, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Cancer is a serious global health threat, and photodynamic therapy (PDT) an effective treatment method for cancer. This works by generating large amount of singlet oxygen (1O2) under the influence light, which induces apoptosis in tumor cells, leading to their destruction. However, resistance cells limits development PDT, thus combination ferroptosis provides new perspective PDT. During PDT ferroptosis, levels 1O2 microenvironment (viscosity) within often change. To address this, this study developed novel fluorescent probe, NI–QM-OH, based on TICT–ICT effect, capable monitoring changes viscosity during The probe exhibits excellent selectivity, high sensitivity, low LOD (0.38 μM), has been successfully applied bioimaging HepG2, HeLa, MCF-7 as well zebrafish. Most importantly, NI–QM–OH also enables visualization diagnosis fatty liver disease (both alcoholic nonalcoholic).

Язык: Английский

---

Lanthanide Nucleotide Photosensitizers for Selective ¹O₂ Generation as Advanced Photo‐Drugs

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Abstract Singlet oxygen ( 1 O 2 )‐mediated specific reactions play vital roles in numerous applications. However, the typically co‐existed reactive species (ROS, mainly superoxide anion, •− and hydroxyl radical, •OH) during photosensitization can cause interferences to above reactions. Herein, boost production yield purity of , this study develops a matrix‐based strategy that propel energy type I II photosensitization. Lanthanide‐nucleotide coordination networks (CNs) are employed as matrix for hosting organic photosensitizers (PSs, e.g., porphyrins phthalocyanines). By isolating PSs from direct contact with H O, resulted PSs@CNs show about threefold boosting, along more than 80% decrease . Using Ce 6 model PSs, obtained 6@CNs exhibit efficient oxidation tryptophan phenol (both seriously interfered by •OH), eventually achieve two advanced photo‐drugs: photo‐induced phospholipase A enzyme inactivation potential venom detoxification situ synthesis chemo‐drug (juglone) cancer therapy.

Язык: Английский

---

NIR light-activated programmable drug immobilization and oxygen modulation for enhanced photodynamic and chemo-therapy

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111195 - 111195

Опубликована: Апрель 1, 2025

Язык: Английский

---

Flexible Regulation of Optical Properties Based on Structure Size‐Driven Intermolecular Interactions for Phototherapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Abstract The precise control of optical properties in molecular systems remains a challenge for phototherapy. Herein, the strategic combination aggregation‐caused quenching (ACQ) and aggregation‐induced emission (AIE) molecule creates ACQ@AIE bimolecular with tunable properties, which are almost unattainable by single‐component materials. Through systematic investigation three systems, it is established that structure size differentials dictate their intermolecular interactions consequent behaviors. Crucially, AIE smaller promotes ACQ clustering to enhance photothermal effect, while when becomes larger, particularly approaching molecule, facilitating π–π stacking boosting photodynamic effect. These distinct assembly modes revealed through combined experimental theoretical analyses, enable regulation versus effects simply regulating ratio molecules. Building on these mechanistic insights, optimal system engineered into nanoparticles exhibit mild strong excellent tumor accumulation retention, achieving near‐complete eradication minimal treatment cycles maintaining good biosafety. This work not only elucidates fundamental size‐interaction‐property relationships but also provides generalizable strategies developing intelligent photo theranostic materials controlled interaction.

Язык: Английский

---

Oxygen‐Independent Two‐Photon Photodynamic Therapy Through Novel Photoinduced Triarylamine‐Radical Cations

Small, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Abstract Photodynamic therapy (PDT) generally employs cytotoxic reactive oxygen species (ROS) for eliminating tumors. However, most photosensitizers rely on to sensitize ROS production, which conflicts with the pathological hypoxia environment in solid Thus, developing oxygen‐independent therapeutic strategies combat of tumors is urgent need. In this work, we report usage novel photoinduced nitrogen radical cations PDT. Three triarylamine derivatives (PNA‐1/2/9) are facilely constructed through a highly efficient one‐step reaction from common commercially available reagents, and demonstrate outstanding oxidative capabilities, confirmed as (PNA •+ ). The generation PNA does not require oxygen, its stability surpasses that ROS, leading more effective PDT outcome. Detailed studies reveal excellent lipid‐droplet targeting high vitro efficacy even hypoxic environments. Remarkably, these triarylamines two‐photon absorbance cross‐sections up 700 GM. Furthermore, effectively inhibition tumor growth observed mouse model under excitation (808 nm). To best knowledge, work first case use PDT, opening new avenue treatment

Язык: Английский

---

Recent Progress in Photothermal, Photodynamic and Sonodynamic Cancer Therapy: Through the cGAS-STING Pathway to Efficacy-Enhancing Strategies

Molecules, Год журнала: 2024, Номер 29(15), С. 3704 - 3704

Опубликована: Авг. 5, 2024

Photothermal, photodynamic and sonodynamic cancer therapies offer opportunities for precise tumor ablation reduce side effects. The cyclic guanylate adenylate synthase-stimulator of interferon genes (cGAS-STING) pathway has been considered a potential target to stimulate the immune system in patients achieve sustained response. Combining photothermal, with cGAS-STING agonists represents newly developed treatment demonstrating noticeable innovation its impact on system. Recent reviews have concentrated diverse materials their function therapy. In this review, we focus molecular mechanism connected role treating cancer.

Язык: Английский

---

Singlet oxygen storage and controlled release for improving photodynamic therapy against hypoxic tumor

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This feature article comprehensively summarizes the research progress related to strategy of singlet oxygen storage and its controlled release in photodynamic therapy dark or hypoxic tumors.

Язык: Английский

---

Acid-Responsive Singlet Oxygen Nanodepot

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

The aSOND releases 1 O 2 slowly at neutral pH for blood stability, but rapidly in acidic tumor environments. This controlled, tumor-specific ROS release offers high selectivity and independence from oxygen/light, promising targeted cancer therapy.

Язык: Английский

---