Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 26, 2024

Abstract The availability of second near‐infrared (NIR‐II) excitable two‐photon photosensitizers with NIR‐I emission for efficient photodynamic therapy (PDT) is limited by challenges in molecular design. In this study, a NIR‐II light‐excitable conjugated microporous polymer ( Tph‐Dbd ) the region developed. large system and delocalized electronic structures endow absorption cross‐section under light excitation. Moreover, electron acceptor donor units within π‐conjugated backbones result high signal‐to‐background ratio imaging, as well separated highest occupied orbital lowest unoccupied distributions excellent singlet oxygen generation ability. activity, emission, good biocompatibility, photostability allow to be used vitro fluorescence imaging guided PDT. impressive photothermal effect can overcome limitations PDT treatment hypoxic tumors. This study highlights strategy designing advanced

Язык: Английский