Heterogeneous Iridium(III) conjugated porous polymer photoredox catalyst based on BODIPY

Separation and Purification Technology, Год журнала: 2025, Номер unknown, С. 131518 - 131518

Опубликована: Янв. 1, 2025

Язык: Английский

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Compartmentalised Single-Chain Nanoparticles and their Function

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Single-chain nanoparticles (SCNPs) are generated by intramolecular collapse and crosslinking of single polymer chains, thus conceptually resembling the structures folded proteins. Their chemical flexibility ability to form compartmentalised nanostructures sized ∼1 nm make them perfect candidates for numerous applications, such as in catalysis drug delivery. In this review we discuss principles design, synthesis analysis SCNPs, with a focus on their structures, highlighting our own previous work. As compartments offer potential generate specific nanoenvironment

Язык: Английский

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Chemo-Selective Transformation of Anthracene Derivative within Water-Soluble Coordination Cages Having Different Cavities

Inorganic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Coordination cages with specific properties and functionalities are utilized as reaction vessels for the desired chemical transformation of substrates. The symmetry inherent cavity coordination can influence host–guest interactions outcome in their confined space. However, impact cage shape on different transformations remains unclear. In this chapter, we report chemo-selective anthracene derivative using three geometrically distinct Pd6 (CC2, CC3, CC4). Photoirradiation 9-bromoanthracene (G3) distorted double-square (CC2) yields anthracene-9,10-dione, while known (CC3) forms a [4 + 4] cycloaddition product. same bowl-shaped (CC4) resulted oxidized Through combination experimental computational studies, demonstrate that size significantly pathways encapsulated derivative, leading to chemo-selectivity. Furthermore, observe encapsulation cavities (CC2 CC4) leads significant enhancement rate photooxidation G3. This work underscores versatility water-soluble synthetic chemistry, offering interesting avenues transformation.

Язык: Английский

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Synthesis and Directed One‐Dimensional Self‐Assembly of Dumbbell‐Shaped Single‐Chain Particles

Journal of Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

ABSTRACT Dumbbell‐shaped single‐chain particles (DSCPs) with distinct sphere‐rod‐sphere morphology were synthesized through intrachain photo‐crosslinking of anthracene‐functionalized polymer chains within an ABA triblock copolymer precursor, where the are tethered at both sides middle comb‐like block. The amphiphilic nature DSCPs, arising from spatial segregation hydrophilic spheres and hydrophobic rods, drives their self‐assembly in mixed THF/H 2 O solvent systems. behavior can be modulated by adjusting rod‐to‐sphere volume ratio, leading to one‐dimensional (1D) nanostructures fiber‐like supercoiled morphologies. rigidity imparted crosslinked spherical heads rod ensures directional stacking assembly, facilitating formation ordered 1D nanostructures. This study highlights critical role crosslinking shape‐amphiphilicity DSCPs directing into nanostructures, offering valuable insights design anisotropic nanomaterials for applications nanomedicine, nanocomposites, functional nanodevices.

Язык: Английский

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Revealing the Folding of Single-Chain Polymeric Nanoparticles at the Atomistic Scale by Combining Computational Modeling and X-ray Scattering

ACS Macro Letters, Год журнала: 2025, Номер unknown, С. 428 - 433

Опубликована: Март 18, 2025

Predicting 3D structures of synthetic heterograft polymers in solution starting from a chemical structure remains great challenge. Here, we get grip on the formed by amphiphilic, random water depending nature hydrophilic graft. Atomistic MD simulations explicit μs time scale show that large Jeffamine-based grafts combined with randomly distributed hydrophobic induce formation worm-like local domains. Replacing Jeffamine glucose affords core–shell ellipsoidal structures. The simulated small-angle X-ray scattering (SAXS) curves simulation results excellent agreement experimental SAXS for copolymers. For glucose-based copolymers, also indicated presence structures, albeit (some) multichain aggregation was present. Our work highlights global conformations very (up to ∼30,000 atoms) can now be studied (accelerated) at atomic solvent 2.5 million atoms). This joint approach constitutes reliable tool understand folding and possible behavior solution, paving way toward predictive modeling nanoparticle polymer's structure.

Язык: Английский

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Photo-thermoresponsive polypyrrole-crosslinked single-chain nanoparticles for photothermal therapy

Communications Chemistry, Год журнала: 2025, Номер 8(1)

Опубликована: Апрель 25, 2025

Abstract Irradiating a chromophore allows cancer diagnostics by photoacoustic (PA) imaging, but also causes transformation of light into thermal energy and so enables therapy photothermal effects. Useful chromophores for (PTT), such as nanoconfined oligomers polymers, should not only display an excellent light-to-heat efficiency, in addition must biocompatibility good water-solubility. We this study have designed water-dispersible, nanocaged polypyrroles (PPy), embedded single-chain nanoparticles (SCNP, sized 6.8 – 8.9 nm) displaying thermoresponsivity, reaching largely increased PTT-effects. Such encaged PPy-SCNPs allow efficient heat conversion temperatures up to 85°C. In parallelized 96-well-plate-design the can effect almost complete death illuminated (cancer) cells at already low concentrations (0.001 mg/mL) with radiant fluxes. The thermoresponsivity SCNPs, surrounding PPy-chains, then responds heat, creating unique self-amplifying imaging.

Язык: Английский

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Amphiphilic Single‐Chain Polymer Nanoparticles as Imaging and Far‐Red Photokilling Agents for Photodynamic Therapy in Zebrafish Embryo Xenografts

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(28)

Опубликована: Июль 7, 2024

This work introduces rationally designed, improved amphiphilic single-chain polymer nanoparticles (SCNPs) for imaging and photodynamic therapy (PDT) in zebrafish embryo xenografts. SCNPs are ultrasmall polymeric with sizes similar to proteins, making them ideal biomedical applications. Amphiphilic result from the self-assembly water of isolated synthetic chains through intrachain hydrophobic interactions, mimicking natural biomacromolecules and, specially, proteins (in size when loaded drugs, metal ions or fluorophores also function). These ultrasmall, soft have various applications, including catalysis, sensing, nanomedicine. Initial vitro experiments nonfunctionalized, a photosensitizing Zn phthalocyanine four nonperipheral isobutylthio substituents, ZnPc, showed promise PDT. Herein, preparation improved, containing ZnPc as highly efficient photosensitizer encapsulated within nanoparticle surrounded by anthracene units is disclosed. The amount groups molecules each controls PDT properties these nanocarriers. Critically, this opens way applications based on first step toward ideal, long-term artificial photo-oxidases (APO).

Язык: Английский

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Efficient Cytosolic Delivery of Single-Chain Polymeric Artificial Enzymes for Intracellular Catalysis and Chemo-Dynamic Therapy

Journal of the American Chemical Society, Год журнала: 2024, Номер 147(1), С. 998 - 1007

Опубликована: Дек. 30, 2024

Designing artificial enzymes for in vivo catalysis presents a great challenge due to biomacromolecule contamination, poor biodistribution, and insufficient substrate interaction. Herein, we developed single-chain polymeric nanoparticles with Cu/N-heterocyclic carbene active sites (SCNP-Cu) function as peroxidase mimics chemo-dynamic therapy (CDT). Compared the enzyme based on unfolded linear polymer scaffold multichain cross-linked scaffold, SCNP-Cu exhibits improved tumor accumulation CDT efficiency both vitro vivo. Protein-like size of SCNP promotes passive diffusion, whereas positive surface charge allows its transcytosis deep penetration hence site. The submolecular compartments effectively protect from protein bindings, thereby providing "cleaner" microenvironment within living system. folded structure facilitates their cytosolic delivery free diffusion cytosol, ensuring efficient contact endogenous H2O2, situ generation toxic hydroxyl radicals (·OH), effective damage intracellular targets (i.e., lipids, nucleic acids). This work establishes versatile SCNP-based nanoplatforms developing catalysis.

Язык: Английский

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Visible light photoflow synthesis of a Cu(ii) single-chain polymer nanoparticle catalyst

Chemical Science, Год журнала: 2024, Номер 15(37), С. 15280 - 15290

Опубликована: Янв. 1, 2024

Single-chain nanoparticles (SCNPs) are folded linear polymer chains inspired by the active state of natural enzymes. The current study addresses synthetic scalability issue SCNP via photoflow synthesis catalytically SCNPs.

Язык: Английский

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Why Single‐Chain Nanoparticles from Weak Polyelectrolytes Can Be Synthesized at Large Scale in Concentrated Solution?

Macromolecular Rapid Communications, Год журнала: 2024, Номер 45(21)

Опубликована: Июль 16, 2024

Here, the unresolved question of why single-chain nanoparticles (SCNPs) prepared from a weak polyelectrolyte (PE) precursor can be synthesized on large scale in concentrated solution is addressed, unlike SCNPs obtained an equivalent neutral (nonamphiphilic) polymer precursor. The combination standard elastic (ESN) model -developed for chains- with classical scaling theory PE solutions provides key. Essentially, long-range repulsion between electrostatic blobs restricts cross-linking process during formation to interior each blob. Consequently, maximum concentration at which PE-SCNPs without interchain not determined by full size but, instead, smaller its blobs. Therefore, up critical where different chains touch other. This 30 times higher than that non-PE precursors. Upon progressive dilution, increases until it reaches bigger under highly diluted conditions. do adopt globular conformation either or solution. It shows main predictions agree experimental results.

Язык: Английский

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