Angewandte Chemie, Год журнала: 2024, Номер 136(46)

Опубликована: Авг. 15, 2024

Abstract Cholesterol is an essential membrane component, and the metabolites from cholesterol play important biological functions to intricately support cancer progression dampen immune responses. Preclinical clinical studies have demonstrated role of metabolism regulation on inhibiting tumor growth, remodeling immunosuppressive microenvironment (TME), enhancing anti‐tumor immunity. In this minireview, we discuss complex in tumors, its progression, influences cells TME. We provide overview recent advances treatment through regulating metabolism. design cholesterol‐altering multifunctional nanomaterials regulate oxidative stress, modulate checkpoints, manipulate mechanical stress responses, alter metabolic pathways. Additionally, examine interactions between established treatments with aim identifying efficient strategies disrupt synergistic combination therapies for effective treatment.

Язык: Английский