Abstract
The
functions
of
living
organisms
are
emergent
from
networks
biomolecules.
In
this
review,
we
discuss
the
creation
synthetic
life‐like
systems
based
on
interplay
peptides
and
porphyrins
in
supramolecular
chemical
systems.
particular,
focus
spatiotemporal
control
self‐assembly
processes,
which
allows
for
development
hierarchical
structures
biomimetic
catalysis
adaptive
dynamics
stimulus‐responsive
structural
transformations.
Notably,
when
operating
a
nonequilibrium
regime–characterized
by
kinetic
traps,
feedback
loops,
dissipative
conditions–the
landscape
expands
system‐level
properties
emerge,
including
transient
catalysis,
metabolic
self‐replication,
Darwinian‐like
evolution.
Controlling
these
at
biointerface
would
facilitate
intelligent
therapeutic
interventions
anti‐tumor
phototherapy.
Supramolecular
chemistry
provides
valuable
framework
exploring
new
physicochemical
spaces
porphyrins,
may
offer
distinct
advantages
extensive
applications
across
diverse
fields.
Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(22)
Опубликована: Май 27, 2025
We
investigate
mechanisms
for
the
observed
nonlinear
growth
in
number
of
polymer
vesicles
generated
during
a
photo-Reversible
Addition-Fragmentation
Chain
Transfer-based
polymerization-induced
self-assembly
(PISA)
reaction.
Our
experimental
results
reveal
presence
self-reproduction
process
which
chemically
active
protocells
are
and
autonomously
light-stimulated
one-pot
reaction
that
starts
from
homogeneous
blend
non-self-assembling
molecules
which,
as
microscopically,
form
vesicular
objects
grow
multiply
(reproduce)
irradiation
with
green
light
(530
nm)
proceeds.
By
using
filtration-based
protocol,
our
experiments
demonstrate
occurs
concomitantly
PISA
increase
photopolymerization
can
only
be
ascribed
to
their
reproduction
via
polymeric
spores
ejected
previously
existing
first-generation
vesicles.
The
second
subsequent
generations’
also
self-reproduce
continue
population
growth.
Abstract
The
functions
of
living
organisms
are
emergent
from
networks
biomolecules.
In
this
review,
we
discuss
the
creation
synthetic
life‐like
systems
based
on
interplay
peptides
and
porphyrins
in
supramolecular
chemical
systems.
particular,
focus
spatiotemporal
control
self‐assembly
processes,
which
allows
for
development
hierarchical
structures
biomimetic
catalysis
adaptive
dynamics
stimulus‐responsive
structural
transformations.
Notably,
when
operating
a
nonequilibrium
regime–characterized
by
kinetic
traps,
feedback
loops,
dissipative
conditions–the
landscape
expands
system‐level
properties
emerge,
including
transient
catalysis,
metabolic
self‐replication,
Darwinian‐like
evolution.
Controlling
these
at
biointerface
would
facilitate
intelligent
therapeutic
interventions
anti‐tumor
phototherapy.
Supramolecular
chemistry
provides
valuable
framework
exploring
new
physicochemical
spaces
porphyrins,
may
offer
distinct
advantages
extensive
applications
across
diverse
fields.
