Oxidative stress in vascular surgical diseases: mechanisms, impacts and therapeutic perspectives

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 9, 2025

The role of oxidative stress in vascular surgical diseases has increasingly been recognized as significant. This paper systematically reviews the specific mechanisms a various condition, including aortic dissection, abdominal aneurysm, thrombosis, diabetic foot, and thromboangiitis obliterans, while also exploring related therapeutic strategies. Oxidative arises from an imbalance between free radicals antioxidants, where excess reactive oxygen species other can exacerbate inflammatory response. delves into pathogenic aforementioned discusses potential methods for utilizing antioxidants to reduce levels. Additionally, this highlights challenges faced by current antioxidant therapies identifies future research directions. By summarizing progress, aims provide theoretical basis more effective treatment strategies diseases, with hope advancing field.

Язык: Английский

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Generalized concept of catalysis for chemical reactions: Nanocatalysis in medicine as a paradigm

Chem, Год журнала: 2025, Номер unknown, С. 102549 - 102549

Опубликована: Апрель 1, 2025

Язык: Английский

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Crystalline Copper Hydroxide Nanosheets with KatG-like Dual Activities for Synergized Nanocatalytic Tumor Therapy

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

The enzyme-mimicking catalytic activities of inorganic nanomaterials have attracted broad attention recently. Catalase-peroxidase (KatG) is a bifunctional enzyme with both catalase and peroxidase that converts hydrogen peroxide (H2O2) into oxygen (O2) radical, respectively. Herein, crystalline Cu(OH)2 nanosheets been synthesized demonstrated as nanocatalysts KatG-like activity for nanocatalytic tumor therapy. distinct structure the features abundant bis(μ-hydroxo)CuIICuII dinuclear catalytically active sites, enabling efficient redox cycling to favor one two-electron transfer O2 generation (catalatic catalysis) two consecutive single-electron transfers hydroxyl radical (•OH) (peroxidatic catalysis), successively. During therapy, by nanomaterial mitigates intratumoral hypoxia sensitizes cancer cells oxidative attack, resulting in significantly enhanced anticancer efficacy. This work bridges dual-active nanocatalysis enzymatic catalysis, presenting its synergy

Язык: Английский

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Co-Mn Complex Oxide Nanoparticles as Potential Reactive Oxygen Species Scavenging Agents for Pulmonary Fibrosis Treatment

Molecules, Год журнала: 2024, Номер 29(21), С. 5106 - 5106

Опубликована: Окт. 29, 2024

Idiopathic pulmonary fibrosis (IPF) is a chronic and age-related lung disease that has few treatment options. Reactive oxygen species (ROS) play an important role in the introduction development of IPF. In present study, we developed multifunctional Cobalt (Co)-Manganese (Mn) complex oxide nanoparticles (Co-MnNPs), which can scavenge multiple types ROS. Benefiting from ROS scavenging activities good biosafety, Co-MnNPs suppress canonical non-canonical TGF-β pathways and, thus, inhibit activation fibroblasts productions extracellular matrix. Furthermore, by reduce LPS-induced expressions pro-inflammatory factors macrophages, suppressing NF-κB signaling pathway. Therefore, excessive matrix deposition inflammatory responses lungs alleviate induced bleomycin (BLM) mice. Taken together, this work offers anti-fibrotic agent for IPF other ROS-related diseases.

Язык: Английский

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Tumor-microenvironment-mediated second near-infrared light activation multifunctional cascade nanoenzyme for self-replenishing O2/H2O2 multimodal tumor therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 930 - 943

Опубликована: Дек. 30, 2024

Язык: Английский

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On the Energy Transfer in Bi2WO6: ERedOx Assisted Radiative Recombination in O2 and ROS Sensing. Prospective

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 7, 2024

Photoluminescence maximum emission signal of colloids based on Bi₂WO₆ suspended in an aqueous solution is blue-shifted as compared to its band gap according E_{g +} (E_RedOx-E_CB). This process involves the exergonic non-radiative transfer E_CB electron E_RedOx and concomitant radiative a second that has gained E_RedOx-E_CB energy presumably by electrons levels entanglement induced via simultaneous light excitement multiple electrons. These results constitute evidence for with application sensing electrolyte-electron-acceptors reactive oxygen species may be implemented example cancer aortic dissection detection treatment.

Язык: Английский

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On the energy transfer in Bi2WO6: ERedOx-assisted radiative recombination in O2 and ROS sensing. prospective

Chemical Papers, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

Язык: Английский

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Research progress on the role of ferroptosis in aortic dissection

Journal of Zhejiang University (Medical Sciences), Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Recent studies have shown that iron metabolism dysregulation and lipid peroxidation-induced ferroptosis, triggered by oxidative stress, play a key role in the development of aortic dissection. Dysregulated leads to excessive production hydroxyl radicals due abnormal levels heme metabolism, while peroxidation is linked Xc

Язык: Английский

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