Trendbericht: Organische Chemie 2025

Nachrichten aus der Chemie, Год журнала: 2025, Номер 73(3), С. 40 - 70

Опубликована: Фев. 28, 2025

Abstract Highlights von November 2023 bis 2024: die erste Einelektron‐C–C‐σ‐Bindung und Anti‐Bredt‐Verbindung; gesättigte Heterocyclen elektrochemisch funktionalisieren; Ausrichten diskotischer Flüssigkristalle; enantioselektive Wagner‐Meerwein‐Umlagerung reiner Aliphaten; photokatalytisch Furanen zu Pyrrolen; mit Ammoniak primären Arylaminen; Metallschrott recyceln ionischen Flüssigkeiten; terminale Alkene Ni‐Katalysatoren zum (Z)‐ oder (E)‐Alken isomerisieren;neue Fungizide, Medikamente Alkaloide.

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Reprogramming the Cyclization of the Sesquiterpene Synthase BcBOT2 Using 2,3-Z-Configured FPP Derivatives and by Means of “Methyl Mapping”

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 8125 - 8139

Опубликована: Май 1, 2025

Язык: Английский

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Engineering terpene synthases and their substrates for the biocatalytic production of terpene natural products and analogues

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Дек. 28, 2024

Summarises recent contributions to rationally engineer terpene synthase catalysis control water capture and utilise substrate analogues produce natural products their analogues.

Язык: Английский

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Chemoenzymatic Formation of Oxa-Terpenoids by Sesqui- and Diterpene Synthase-Mediated Biotransformations with 9-Oxy-FPP Ether Derivatives

Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 28, 2024

Farnesyl pyrophosphate derivatives bearing an additional oxygen atom at position 5 proved to be very suitable for expanding the substrate promiscuity of sesquiterpene synthases (STSs) and formation new oxygenated terpenoids. Insertion in 9, however, caused larger restraints that led restricted acceptance by STSs. In order reduce some proposed restrictions, two FPP-ether with altered substitution pattern around terminal olefinic double bond were designed. These showed improved toward different Four cyclized terpenoids embedded ether group isolated characterized. case cyclic enol ethers, also corresponding "hydrolysis" products, linear hydroxyaldehydes, isolated. Interestingly, all cyclization products originate from initial 1 → 12 unprecedented when native farnesyl serves as a substrate. We found most FPP derivative 9 does not carry any methyl on alkene, which likely reduces steric congestion preferred conformation is adopted active site.

Язык: Английский

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Notizen aus der Forschung

Nachrichten aus der Chemie, Год журнала: 2024, Номер 72(10), С. 48 - 51

Опубликована: Сен. 30, 2024

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