Dual Metabolism-Disrupted Nanoparticles for Reprogramming the Immune Microenvironment to Potentiate Cuproptosis Immunotherapy

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101799 - 101799

Опубликована: Апрель 1, 2025

Язык: Английский

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Nanoarchitecting intelligently encapsulated designs for improved cancer therapy

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Май 1, 2025

Despite the success in exploring various aspects of origination and therapeutic strategies, cancer has remained one most dreadful metabolic disorders due to failure eradicate tumors comprehensively frequent recurrence because acquired resistance drugs. Recently, several advancements have been evidenced fabrication smart nanocarriers encapsulated with multiple components. Several reasons for nanoencapsulation include enhancement bioavailability drugs, precise targetability reduce adverse effects on normal cells, ability enable controlled drug release rates at tumor sites. In addition, these protect cargo from deactivation, responsively delivering it based physiological or pathological characteristics tumors. this review, we present approaches therapy, including organic materials, inorganic components, their composites, as well biomembrane-based strategies. These along practical applications potential treatment, are discussed depth, highlighting advantages disadvantages, aiming reveal ultimate prospects enhancing delivery efficiency targeted therapy.

Язык: Английский

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Ultrasound‐Triggered Nanoparticles Induce Cuproptosis for Enhancing Immunogenic Sonodynamic Therapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 13, 2025

Abstract Cuproptosis, as a novel mechanism of cell death, holds significant promise for tumor therapy. However, existing studies typically employ methods to induce cuproptosis through endogenous or exogenous pathways, which often fail achieve precise control in both space and time. Herein, polymeric nanoparticles (RC NPs) are developed that enable activation acoustic tumor‐specific treatment. The fabricated via self‐assembly degradable, acoustic‐sensitive polymer (Poly RA) metal‐ion‐loadable polyphenol‐structured MPN). Ultrasound stimulation cleaved the RC NPs, generating reactive oxygen species (ROS) promoting release copper ions from Poly MPN, leading aggregation lipoylated proteins depletion iron‐sulfur cluster introduce cuproptosis. Subsequently, NPs successfully activated immune system mice, maturation antigen‐presenting cells T lymphocytes. exhibited good biosafety inhibition orthotopic patient‐derived xenograft (PDX) models. These provide promising modality treatment highly aggressive cancers valuable avenue future clinical applications.

Язык: Английский

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Recent advances in nanomedicine targeting amino acid metabolism for anti-tumor therapy

Journal of Nanoparticle Research, Год журнала: 2025, Номер 27(6)

Опубликована: Июнь 1, 2025

Язык: Английский

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MnO2 and sonosensitizer-based nano-platforms for cancer sonodynamic therapy

Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157232 - 157232

Опубликована: Окт. 30, 2024

Язык: Английский

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Targeting metabolic pathway enhance CAR-T potency for solid tumor

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113412 - 113412

Опубликована: Окт. 24, 2024

Язык: Английский

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DNAzyme-loaded bimetallic nanoflowers for STING activation and dual metabolic regulation to enhance antitumor immunity

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 157697 - 157697

Опубликована: Ноя. 1, 2024

Язык: Английский

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