Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and subsequent release DNA (mtDNA), which is anticipated to activate cGAS-STING pathway, thereby augmenting antitumor immune response. However, challenges lie in effectively triggering cancer cells subsequently enhancing activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 a semiconductor structure enzyme-like activity generated substantial amount reactive oxygen species (ROS) under stimulation by endogenous H2O2 exogenous ultrasound. Importantly, discovered that Co-based nanomaterials themselves induce cells. Therefore, initially acted as inducers, caspase-1/GSDMD-dependent via Co2+ ROS, leading mtDNA release. Subsequently, were further utilized STING agonists specifically capable detecting pathway. These cascade events triggered robust response, modulating immunosuppressive tumor microenvironment into an immune-supportive state, providing favorable support therapy. This innovative strategy not only significantly impeded growth primary but also elicited response augment efficacy checkpoint inhibitors preventing distant progression. Overall, this study proposed self-cascade activating amplifying pathway specificity mediated pyroptosis, representing valuable avenue future

Язык: Английский

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Cd Single Atom as an Electron Mediator in an S‐Scheme Heterojunction for Artificial Photosynthesis of H₂O₂

Advanced Energy Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Abstract Developing conductor‐mediated S‐scheme heterojunction photocatalysts imitating natural photosynthetic systems emerges as a promising approach to hydrogen peroxide (H 2 O ) production. However, achieving precise coupling between two semiconductors with charge shuttle and modulating the interfacial interactions still remain significant bottleneck. Herein, we propose catalyst architecture Cd single atom mediated formed by interfacing CdS TiO nanoparticles. This exhibits an H production rate high 60.33 µmol g −1 min under UV–vis light irradiation, which is attributed efficient transport at interface of thanks S‐scheme. In‐situ X‐ray photoelectron spectroscopy (XPS) electron spin resonance (ESR) spin‐trapping tests confirm transfer route. Femtosecond transient absorption (fs‐TA) other ex‐situ characterizations further corroborate across interface. work offers new perspective on constructing atoms heterojunctions enhance photocatalytic performance.

Язык: Английский

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Cu₂O_1–x-Superlattices Induced Oxygen Vacancy for Localized Surface Plasmon Resonance

Nano Letters, Год журнала: 2025, Номер 25(2), С. 922 - 930

Опубликована: Янв. 3, 2025

Metallic oxide can induce localized surface plasmon resonance (LSPR) through creating vacancies, which effectively achieve high carrier concentrations and offer advantages such as versatility tunability. However, vacancies are typically created by altering the stoichiometric ratio of elements doping, it is challenging to LSPR enhancement in visible spectral range. Here, we have assembled Cu2O1–x-superlattices a concentration oxygen resulting within spectrum. Combining this technique with theoretical models, elucidated mechanism behind origin LSPR. We also provide evidence strong uniform exhibited structure under light. This significantly enhances electromagnetic field semiconductor-based surface-enhanced Raman scattering (SERS), detection limit reaching 10–9 M compared conventional gold nanoparticles (55 nm). Our strategy provides new perspective potential for controlling generating metal nanoparticles.

Язык: Английский

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An Artificial Piezoelectric-Conductive Integrated Peri-Implant Gingiva Enables Efficient Bacterial Inhibition and Soft-Tissue Integration

Advanced Fiber Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Язык: Английский

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Charge Separation‐Engineered Piezoelectric Ultrathin Nanorods Modulate Tumor Stromal Microenvironment and Enhance Cell Immunogenicity for Synergistically Piezo‐Thermal‐Immune Therapy

Small, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 16, 2024

Abstract The tumor microenvironment (TME) is characterized by hypoxia and low immunogenicity, with a dense rigid extracellular matrix (ECM) that impedes the diffusion of therapeutic agents immune cells, thereby limiting efficacy immunotherapy. To overcome these challenges, an oxygen defect piezoelectric‐photothermal sensitizer, bismuth vanadate nanorod‐supported platinum nanodots (BVP) developed. integration enhances photothermal effect improves charge separation efficiency under ultrasound, leading to increased heat generation production reactive species (ROS) oxygen. Platinum also catalyzes conversion hydrogen peroxide in TME oxygen, which serves as both ROS source means alleviate hypoxia, reversing immunosuppressive TME. Moreover, coordination ions glutathione further amplifies cellular oxidative stress. generated not only denature collagen ECM, facilitating deeper penetration BVP into but induce immunogenic cell death cells. Through “degeneration penetration” strategy, photoacoustic therapy effectively activates inhibiting growth metastasis. This study introduces pioneering approach design antitumor nanomedicines aimed at characteristics

Язык: Английский

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Synthesis of CuCl2/PTFE with high piezoelectric effects for efficient degradation of antibiotics: Radical mechanism investigation

Chemical Engineering Science, Год журнала: 2025, Номер unknown, С. 121274 - 121274

Опубликована: Янв. 1, 2025

Язык: Английский

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Solvent-free fabrication of ultrathin two-dimensional metal oxides/sulfides in a fixed interlayer by geometric confinement

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 13, 2025

Язык: Английский

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Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS 2 ) nanoflowers are strategically designed, which exhibit enhanced effects. Specifically, introduction Co single atom not only induces lattice distortion out‐of‐plane polarization but also leads to formation numerous vacancies. These changes collectively narrow intrinsic bandgap material, facilitating effective separation migration charge carriers, enabling efficient production reactive oxygen species under ultrasound stimulation. Additionally, SA‐Co@MoS demonstrate improved enzymatic activity glutathione depletion capabilities attributed mixed valence states Co, intensifying oxidative stress cells, leading cell cycle arrest apoptosis, while inactivation peroxidase 4 ferroptosis. Both vitro vivo results indicate that can significantly eliminate cells. This study offers valuable insights into exploration doping‐enhanced sonosensitizers for cancer treatment, potentially paving way advancements field synergistic enzyodynamic therapy.

Язык: Английский

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Inorganic Nanobiomaterials Boost Tumor Immunotherapy: Strategies and Applications

Accounts of Chemical Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

ConspectusTumor immunotherapy, as a new antitumor method to fight cancer by activating or enhancing the body's own immune system, has been extensively studied and applied in clinical practice. However, an extremely complex tumor heterogeneity immunosuppressive microenvironment (TME) lead poor response rate secondary drug resistance. The advent of nanotechnology ushered era for immunotherapy. In particular, inorganic nanomaterials, with their unique physicochemical properties excellent biocompatibility, are becoming important tool Inorganic nanomaterials can be used carriers agents, improving delivery efficiency thereby reducing systemic immunotoxicity responses. also trigger immunogenic cell death (ICD), stimulate responses, alleviate TME increasing oxygen levels, modulating metabolic pathways, altering secretion cytokines. synergistic integration immunotherapy adeptly navigates around constraints conventional treatments, side effects while concurrently augmenting therapeutic efficacy. this review, we summarize our recent efforts design synthesis nanobiomaterials enhance efficacy These achieve desired mainly through four strategies, including inducing ICD, developing nanovaccines, pyroptosis, regulating metabolism, providing beneficial implications For one thing, due deficiency ICD effect single therapy, developed nanocatalysts that integrate multiple functions play catalytic role TME, converting substances metabolites into products situ, further ICD. another, order solve problems low antigen loading existing adjuvants, several novel multifunctional nanoadjuvants were prepared, which combine high multimode function one, efficient activation. Moreover, attain strong inflammatory responses immunogenicity, engineer pyroptosis adjuvants selectively induce intracellular oxidative stress ion overload. Finally, reverse microenvironment, nanoplatforms target levels nutrients such glucose, lactic acid, citric tryptophan effectively alter response. implementation these strategies not only improves but reduces provides valuable insights references development assist

Язык: Английский

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Low-Power Optoelectronic NO₂ Sensors by Constructing ZnS/SnS₂ Heterojunctions

ACS Applied Electronic Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 12, 2025

Язык: Английский

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