Abstract
Perovskite‐phase
Bi
4
Ti
3
O
12
(BTO)
is
recognized
as
a
potential
candidate
for
solar‐powered
water‐splitting
due
to
its
special
conduction‐band
and
valence‐band
positions.
However,
broadband
defect
surface
chemical
inertness,
it
difficult
obtain
outstanding
performance
under
photoirradiation.
Herein,
donor‐acceptor
system
with
synergistically
interacted
heterointerface
constructed
by
growing
TiO
2
nanoparticles
on
BTO
microspheres,
an
internal
high‐speed
electron
transfer
channel
established
improve
the
photoelectric
property
electronic
interaction
of
Pt
nanocatalyst.
Due
excellent
broadband‐light
harvesting
capacity,
significantly
accelerated
photoexciton
separation/transfer,
introduction
abundant
active
sites,
effectively
hindered
recombination,
thereby
≈3093.16
µmol·g
−1
·h
H
O‐to‐H
rate
(pH
=
11)
673.85
O‐to‐O
4)
are
achieved
simulated
sunlight
irradiation,
reaching
≈0.1062%
solar‐to‐exciton
utilization
efficiency,
which
obviously
outperformed
majority
recently
reported
photocatalysts.
After
process
PVDF‐networked
membrane,
stable
activity
maintained
during
10
cycles
(50
h)
reinforced
organic–inorganic
interface
convenient
separation/recovery
property.
This
study
proposes
valuable
strategy
improving
BTO‐based
photocatalyst.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 8, 2025
Piezocatalyst-enabled
sonopiezoelectric
therapy
offers
noninvasive
treatment
with
high
spatiotemporal
selectivity,
yet
existing
piezocatalysts
are
limited
by
suboptimal
efficacy,
cancer
cell
resistance
to
oxidative
stress,
and
biosafety
concerns.
Here,
hafnia
(HfO2),
one
of
the
only
few
FDA-approved
inorganic
nanomaterials
for
clinical
trials,
is
identified
as
a
promising
piezocatalyst
translational
potential
enzymatic
PANoptosis-boosted
nanocatalytic
therapy.
Specifically,
engineered
transition
metal-substituted
HfO2
nanocatalysts
synthesized
optimize
piezoelectric
enzyme-mimicking
activities.
Among
these,
Mn-substituted
20%
Mn
ratio
(HMO)
demonstrates
superior
performance
in
sono-triggered
reactive
oxygen
species
generation,
attributed
its
reduced
bandgap
increased
vacancies.
HMO
also
exhibits
multiple
activities,
including
peroxidase
(POD),
catalase
(CAT),
glutathione
(GPx),
amplifying
stress
through
tumor-specific
catalytic
reactions.
These
dual
effects
enable
activation
PANoptosis
elicit
robust
antitumor
immune
response.
Biological
evaluations
show
significant
tumor
suppression
responses
HMO-mediated
Unlike
utilizing
radiosensitization
ability
clinic,
this
work
unveils
distinctive
effect
multienzymatic
activities
HfO2-based
biomedical
applications,
holding
overcome
challenges
radiation
damage
associated
radiotherapy.
A
novel
PN-bioHJ
membrane
combining
black
phosphorus
and
barium
titanate
on
a
PLGA
platform
achieves
>99%
antibacterial
efficiency
under
ultrasound,
with
excellent
biocompatibility
for
infected
tissue
regeneration.
Accounts of Chemical Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
ConspectusTumor
immunotherapy,
as
a
new
antitumor
method
to
fight
cancer
by
activating
or
enhancing
the
body's
own
immune
system,
has
been
extensively
studied
and
applied
in
clinical
practice.
However,
an
extremely
complex
tumor
heterogeneity
immunosuppressive
microenvironment
(TME)
lead
poor
response
rate
secondary
drug
resistance.
The
advent
of
nanotechnology
ushered
era
for
immunotherapy.
In
particular,
inorganic
nanomaterials,
with
their
unique
physicochemical
properties
excellent
biocompatibility,
are
becoming
important
tool
Inorganic
nanomaterials
can
be
used
carriers
agents,
improving
delivery
efficiency
thereby
reducing
systemic
immunotoxicity
responses.
also
trigger
immunogenic
cell
death
(ICD),
stimulate
responses,
alleviate
TME
increasing
oxygen
levels,
modulating
metabolic
pathways,
altering
secretion
cytokines.
synergistic
integration
immunotherapy
adeptly
navigates
around
constraints
conventional
treatments,
side
effects
while
concurrently
augmenting
therapeutic
efficacy.
this
review,
we
summarize
our
recent
efforts
design
synthesis
nanobiomaterials
enhance
efficacy
These
achieve
desired
mainly
through
four
strategies,
including
inducing
ICD,
developing
nanovaccines,
pyroptosis,
regulating
metabolism,
providing
beneficial
implications
For
one
thing,
due
deficiency
ICD
effect
single
therapy,
developed
nanocatalysts
that
integrate
multiple
functions
play
catalytic
role
TME,
converting
substances
metabolites
into
products
situ,
further
ICD.
another,
order
solve
problems
low
antigen
loading
existing
adjuvants,
several
novel
multifunctional
nanoadjuvants
were
prepared,
which
combine
high
multimode
function
one,
efficient
activation.
Moreover,
attain
strong
inflammatory
responses
immunogenicity,
engineer
pyroptosis
adjuvants
selectively
induce
intracellular
oxidative
stress
ion
overload.
Finally,
reverse
microenvironment,
nanoplatforms
target
levels
nutrients
such
glucose,
lactic
acid,
citric
tryptophan
effectively
alter
response.
implementation
these
strategies
not
only
improves
but
reduces
provides
valuable
insights
references
development
assist
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 28, 2025
Low
immunogenicity
and
insufficient
infiltration
of
immune
cells
are
the
main
factors
affecting
therapeutic
efficacy
melanoma
immunotherapy.
Ultrasound-triggered
sonodynamic
therapy
(SDT)
based
on
piezoelectric
materials
has
attracted
substantial
attention
due
to
its
high
efficiency
catalytic
generation
reactive
oxygen
species
(ROS)
induce
immunogenic
cell
death
(ICD).
However,
hypoxic
environment
in
solid
tumors
hinders
limits
SDT
effect.
Herein,
we
construct
a
novel
Ir-C3N5
nanocomplex
that
uses
nitrogen-rich
carbon
nitride
(C3N5)
nanosheets
as
nanoligands
Ir(tpy)Cl3
precursor.
The
newly
formed
exhibits
narrowed
band
gap
an
enlarged
dipole
moment,
resulting
better
electron-hole
pair
separation
bending,
contributing
ROS
burst
upon
ultrasonic
activation.
In
addition,
Ir(III)
enables
C3N5
catalyze
degradation
H2O2
O2,
alleviating
tumor
hypoxia
reinforcing
efficacy.
Mechanistically,
by
catalysis,
can
target
lysosomes
trigger
autophagy
inhibition
caused
lysosome
rupture
evoke
pyroptosis.
More
importantly,
cleaved
caspase-1/GSDMD-N
pyroptosis
pathway
activated
was
associated
with
ICD,
effectively
initiating
innate
adaptive
immunity
body
for
suppressing
metastasis
relapse.
Abstract
Sonodynamic
therapy
(SDT)
is
a
promising
cancer
treatment
due
to
its
ability
utilize
ultrasound
(US)
activate
sonosensitizers,
generating
reactive
oxygen
species
(ROS)
for
tumor
suppression.
High‐valence
bismuth,
known
unique
photoacoustic
properties
and
biocompatibility,
has
shown
great
potential
when
combined
with
SDT.
However,
conventional
sonosensitizers
large
bandgaps
electron‐hole
recombination
have
limited
SDT's
effectiveness.
Herein,
bismuth‐based
piezoelectric
sonosensitizer
developed,
DSPE‐PEG
2000‐modified
KBiO
3
(KBP),
which
features
reduced
bandgap
(1.9
eV).
This
facilitates
electron
transfer
depletes
glutathione
in
the
microenvironment.
Under
US,
KBP
generates
significant
amount
of
ROS,
leading
cell
pyroptosis
via
ROS‐NLRP3‐Caspase‐1‐GSDMD
pathway.
Both
vitro
vivo
experiments
demonstrated
that
SDT
can
effectively
inhibit
growth.
research
offers
novel
approach
by
leveraging
advantages
SDT,
demonstrating
clinical
inhibition.
