Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 3, 2024
This study presents 3-pyrrolyl BODIPY-based Schiff base and benzothiazole derivatives with tunable red-to-NIR properties, highlighting a Re( i ) complex distorted octahedral geometry for its potential in coordination chemistry.
Язык: Английский
European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(42)
Опубликована: Авг. 14, 2024
Abstract Tris(3‐pyrrolyl BODIPY) on 1,3,5‐triazine scaffold was synthesized over a sequence of steps starting from commercially available cyanuric chloride. The chloride reacted with p‐hydroxy benzaldehyde to afford tris(p‐oxybenzaldehyde) which then excess pyrrole under acid catalyzed conditions 1,3,5‐triazine‐tris(meso‐p‐oxyphenyl dipyrromethane). Subsequent in situ oxidation this compound DDQ obtain tris(meso‐oxyphenyldipyrromethene) treated followed by the addition Et 3 N/BF ⋅ OEt 2 afforded fluorescent tris(3‐pyrrolyl BODIPY). For comparison, tris(BODIPY) triazine prepared oxidizing tris(meso‐oxyphenyldipyrromethane) complexation BF . Both compounds were thoroughly characterized and studied various experimental theoretical methods. Absorption, steady state fluorescence, time‐resolved transient‐absorption studies revealed that BODIPY), excitonic interactions between two three 3‐pyrrolyl BODIPY units resulted hypsochromic shift spectral bands, reducing quantum yield singlet lifetime whereas did not show such interactions. DFT helped understanding both solution solid state. viscosity indicated fluorescence increases significantly solvent viscosity, suggesting its potential for measuring cellular during physiological processes.
Язык: Английский
Процитировано
1
Advanced Optical Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 24, 2024
Abstract Photomodulable fluorophores constitute advanced materials as they possess the ability to modify their photophysical properties upon photoirradiation. A new mechanism of photoconversion is recently established, called Directed Photooxidation Induced Conversion based on coupling with Aromatic Singlet oxygen Reactive Moieties (ASORMs). In this work, The (DPIC) intended be applied Perylene BisImide (PBI) due its appealing properties. experimental results showed that two ASORMs PBI core, here furan and pyrrole, led impressive photomodulable fluorophores. While PBI‐F exhibited a 100 nm shift, PBI‐P displayed an 80‐fold fluorescence intensity enhancement photoactivation. Analysis photoproducts conversion do not involve addition singlet ASORM. Instead, occurred through efficient successive photocyclizations. Finally, intracellular vesicles are successfully photoconverted by means endocytosed PLGA‐polymer nanoparticles loaded PBI‐F. This study highlights unique capability furan‐ pyrrole‐conjugated enable optical phototransformation
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июнь 24, 2024
Abstract Photoactivatable fluorescent probes are valuable tools in bioimaging for tracking cells down to single molecules and molecule localization microscopy. For the latter application, green emitting dyes demand. We herein developed an efficient green-emitting photoactivatable furanyl-BODIPY (PFB) we established a new mechanism of photoactivation called Directed Photooxidation Induced Activation (DPIA) where furan is photo-oxidized directed manner by singlet oxygen produced probe. The photoconverter (93-fold fluorescence enhancement at 510 nm, 49% yield conversion) functionalizable allowed targeting several subcellular structures organelles, which were photoactivated live cells. Finally, demonstrated potential PFB super-resolution imaging performing PhotoActivated Localization Microscopy (PALM)
Язык: Английский
Процитировано
0
Methods and Applications in Fluorescence, Год журнала: 2024, Номер 13(1), С. 015002 - 015002
Опубликована: Ноя. 14, 2024
The escalating prevalence of hospital-acquired infections poses a critical challenge for healthcare systems worldwide. Effective management requires rapid identification pathogens and their antibiotic resistance profiles. In this study, we utilized the photoconvertible mEos4b protein, which transitions from green to red fluorescence upon blue light exposure, distinguish live dead bacteria. gene was cloned into prokaryotic vector expressed in
Язык: Английский
Процитировано
0
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 3, 2024
This study presents 3-pyrrolyl BODIPY-based Schiff base and benzothiazole derivatives with tunable red-to-NIR properties, highlighting a Re( i ) complex distorted octahedral geometry for its potential in coordination chemistry.
Язык: Английский
Процитировано
0