
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Дек. 3, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Дек. 3, 2024
Язык: Английский
Journal of the American Chemical Society, Год журнала: 2024, Номер unknown
Опубликована: Дек. 11, 2024
The homogeneous catalytic hydrogenation of benzo-fused heteroarenes generally provides partially hydrogenated products wherein the heteroaryl ring is preferentially reduced, such as quinoline hydrogenation, leading to 1,2,3,4-tetrahydroquinoline. Herein, we report a carbocycle-selective fused
Язык: Английский
Процитировано
8Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 25, 2025
Abstract The rapid assembly of diverse cyclic amines from simple precursors is now considered as an ideal platform with respect to efficiency and sustainability. To date, numerous synthetic methods have been successfully developed however, most them are limited a narrow subset amines, variations in ring size often requiring different substrates distinct strategies. Furthermore, the “escape‐from‐Flatland” concept has led chemists focus on synthesis C(sp 3 )‐rich small molecules for potential drug candidates. Herein, successful realization radical‐polar crossover bicyclization reaction reported easily available cyclopropylamines substituted alkenes through photoredox catalysis. This approach introduces innovative methodology de novo collection 4/5‐, 5/5‐, 6/5‐,7/5‐, 5/6‐fused saturated bicyclic systematic modular manner excellent diastereoselectivity. work highlights utility photoinduced radical–polar bicyclization, applicability which showcased by functional group tolerance, wide substrate scopes, derivatization reactions.
Язык: Английский
Процитировано
1Journal of Catalysis, Год журнала: 2025, Номер unknown, С. 115937 - 115937
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Catalysis Letters, Год журнала: 2025, Номер 155(4)
Опубликована: Март 5, 2025
Язык: Английский
Процитировано
0Drug Discovery Today, Год журнала: 2024, Номер unknown, С. 104212 - 104212
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
2Journal of the American Chemical Society, Год журнала: 2024, Номер unknown
Опубликована: Дек. 4, 2024
The reduction of abundant benzene rings to scarce C(sp3)-rich motifs is invaluable for drug design, as C(sp3) content known correlate with clinical success. Cyclohexenes are attractive targets, they can be rapidly elaborated into large product libraries and stable against rearomatization. However, partial reactions benzenes cyclohexenes rare have a very narrow scope. Herein we report broadly applicable method that converts electron-poor tolerates Lewis-basic functional groups such triazoles thioethers well reducible cyanides, alkynes, sulfones. reaction utilizes an organic donor induces mild arene by preassociation photoexcitable electron donor–acceptor (EDA) complex isomerization redox-inert 1,4-cyclohexadienes 1,3-cyclohexadienes without strong base in its oxidized thioquinone methide form.
Язык: Английский
Процитировано
2Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Дек. 3, 2024
Язык: Английский
Процитировано
0