Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

A visible-light-induced method for the hydrodichloromethylation of unactivated alkenes using chloroform (CHCl3) was developed, employing pyridine·BH3 as halogen atom transfer (XAT) reagent. The strategy showed a broad functional group tolerance, and 29 examples alkenes, including complex natural products or drug derivatives, have been established with good yields. Mechanistic studies indicated that CHCl3 serves both source dichloromethyl radical hydrogen (HAT) reagent, borane short-chain reaction process involved in this system. This represents novel approach without an additional HAT

Язык: Английский