Cross-talks of GSH, mitochondria, RNA m6A modification, NRF2, and p53 between ferroptosis and cuproptosis in HCC: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 302, С. 140523 - 140523

Опубликована: Фев. 1, 2025

Язык: Английский

---

Cuproptosis Nanoprodrug-Initiated Self-Promoted Cascade Reactions for Postoperative Tumor Therapy

Biomaterials, Год журнала: 2025, Номер 318, С. 123176 - 123176

Опубликована: Фев. 7, 2025

Язык: Английский

---

A Highly‐Active Chemodynamic Agent Based on In Situ Generated Copper Complexes from Copper Hexacyanoferrate Nanoparticles

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract Copper hexacyanoferrate (Cu 2 Fe(CN) 6 ) nanocubes with a homogeneous size under 100 nm are synthesized by self‐assembly from Cu 2+ and 3− precursors. Similar to previous reports catalysts containing Fe, the objective is produce nanoparticle catalyst that can promote glutathione (GSH) oxidation thanks contribution, plus some ROS production through Fenton‐like processes fostered Fe. Unexpectedly, catalytic activity for GSH much higher (≈50%) than those obtained equal amounts provided as CuCl . Furthermore, in presence of concentrations characteristic tumor microenvironment, disassembled homogeneously, without noticeably change composition. These results suggest this strong increase arises synergistic coordination released ions facilitate deprotonation, accelerating its oxidation. Given role disassembly process, selective action be obtained: lethal doses low 18 ppm U251‐MG cancer cells while healthy fibroblasts largely spared.

Язык: Английский

---

A Copper‐Based Photothermal‐Responsive Nanoplatform Reprograms Tumor Immunogenicity via Self‐Amplified Cuproptosis for Synergistic Cancer Therapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Studies show that intracellular accumulation of copper ions causes cuproptosis, potentially enhancing anticancer immunity. However, the induction cuproptosis inevitably faces challenges due to low deliver efficiency and collateral damage normal tissues. This paper presents a self-amplified nanoplatform (CEL NP) composed Cu2- XS hollow nanospheres (HNSs), elesclomol (ES), phase-change material lauric acid (LA). Under NIR-II laser irradiation, photothermal energy generated by HNSs melts LA, facilitating precise release ES within tumor microenvironment. Notably, can traverse cell membrane form ES-Cu(II) complexes, thereby delivery cells. Excess Cu(II) also reacts with endogenous glutathione, reducing its inhibitory effect on cuproptosis. Ultimately, this amplified activate immunogenic death, eliciting robust immune response promoting suppression. The CEL NP-mediated offers novel approach for therapy through induction.

Язык: Английский

---

An up‐To‐Date Review of Elesclomol and Its Nano‐Formulations in Cancer Therapy

Cancer Reports, Год журнала: 2025, Номер 8(4)

Опубликована: Апрель 1, 2025

ABSTRACT Background Elesclomol (ES) is a promising anticancer compound that exerts its effects through multiple mechanisms. It acts as copper (Cu(II)) ionophore, forming an ES–Cu complex within cancer cells and inducing novel form of cell death called cuproptosis. Aim To provide up‐to‐date review on elesclomol nano‐formulations with particular focus therapy. Sources Literature was collected by manually searching in Pubmed, Google Scholar, clinicaltrials.gov March 2025. Content This provides overview the discovery development ES molecule, including physicochemical properties. New insights into intracellular interactions mechanisms transportation are then explained. The recent clinical outcomes therapy, both monotherapy combination paclitaxel or carboplatin, summarized. While initial trials showed promise, more studies focusing preclinical investigations complex. Nanomedicine‐based formulations have emerged strategy to enhance delivery well therapeutic effects, several nanomedicines currently under development. nanoparticle strategies discussed. comprehensive advancements study, mechanism action, progress, potential nanomedicine‐based approaches improve efficacy treatment.

Язык: Английский

---

Therapeutic application of nanosystems-based metalloptosis for enhanced tumor radiotherapy

Coordination Chemistry Reviews, Год журнала: 2025, Номер 536, С. 216666 - 216666

Опубликована: Апрель 10, 2025

Язык: Английский

---

Polyvalent aptamer DNA nanoassembly based near-infrared carbon dots and rolling circle amplification for synergistic therapy of breast cancer

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 310, С. 143343 - 143343

Опубликована: Апрель 23, 2025

Язык: Английский

---

Disruption of self-protection pathways enables endogenous copper-evoked cuproptosis via bioorthogonal nanoblocker

Nano Today, Год журнала: 2024, Номер 61, С. 102608 - 102608

Опубликована: Дек. 25, 2024

Язык: Английский

---