The Advances in the Development of Epigenetic Modifications Therapeutic Drugs Delivery Systems
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 10623 - 10637
Опубликована: Окт. 1, 2024
Epigenetic
dysregulation
can
significantly
trigger
the
onset
and
progression
of
various
diseases,
epigenetic
therapy
is
a
new
treatment
strategy
by
changing
DNA
methylation,
histone
modification,
N6-methyladenosine,
chromatin
modification
other
modifications
to
regulate
gene
expression
levels
for
therapeutic
purposes.
However,
small-molecule
drugs
face
challenges
in
disease
treatment,
such
as
lack
selectivity,
limited
efficacy,
insufficient
safety.
Nanomedicine
delivery
systems
offer
significant
advantages
addressing
these
issues
enhancing
drug
targeting,
improving
bioavailability,
reducing
nonspecific
distribution.
This
help
minimize
side
effects
while
increasing
both
effectiveness
safety
drugs.
In
this
review,
we
focus
on
mechanism
role
regulatory
factors
well
faced
small
molecule
inhibitors
strategies,
especially
research
advancements
systems,
review
discuss
potential
using
nanotechnology
develop
systems.
Язык: Английский
Enzymatic Reactions of S-Adenosyl-L-Methionine: Synthesis and Applications
Biochemistry (Moscow),
Год журнала:
2025,
Номер
90(S1), С. S105 - S134
Опубликована: Фев. 1, 2025
Язык: Английский
Chimeric cofactors enable methyltransferase-catalyzed prenylation
Chem,
Год журнала:
2025,
Номер
unknown, С. 102538 - 102538
Опубликована: Апрель 1, 2025
Язык: Английский
Selective chemical tracking of DNA methylomes in live cells
Epigenomics,
Год журнала:
2025,
Номер
unknown, С. 1 - 3
Опубликована: Май 6, 2025
Язык: Английский
Bridging bioengineering and epigenetics: from technical innovations to clinical applications
Epigenetics Communications,
Год журнала:
2024,
Номер
4(1)
Опубликована: Дек. 24, 2024
The
7th
International
Conference
on
Epigenetics
&
Bioengineering
held
in
Amsterdam,
Netherlands
was
a
successful
event
covering
cutting-edge
research
utilizing
innovative
technologies
from
multidisciplinary
international
scientists
the
fields
of
epigenetics
and
bioengineering,
with
an
emphasis
development
disease.
This
conference
report
highlights
outstanding
presented
engaging
discussions
that
took
place.
Throughout
sessions,
leading
experts
demonstrated
novel
to
explore
epigenetic
mechanisms,
including
advanced
data
analysis
pipelines
bioengineered
systems.
Several
speakers
uncovered
emerging
fundamental
principles
how
these
insights
are
being
applied
address
(bio)medical
challenges,
underscoring
field
is
progressing
toward
(pre)clinical
applications
targeted
therapies.
featured
stimulating
causal
relationship
between
marks
transcription,
emphasizing
importance
standardizing
editing
methodologies.
Язык: Английский