Enantioselective Cobalt-Catalyzed Remote Hydroboration of Alkenylboronates
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Heteroatomic
groups
in
alkenes
typically
direct
thermodynamically
favored
chain
walking
of
C═C
bonds
toward
themselves,
thereby
facilitating
C-H
bond
functionalization
near
the
heteroatoms.
We
present
herein
an
efficient
cobalt-catalyzed
contra-thermodynamic
remote
hydroboration
alkenylboronates
with
pinacolborane
to
synthesize
chiral
1,n-diboronates.
This
protocol
features
a
broad
substrate
scope,
high
functional
group
tolerance,
and
excellent
enantioselectivity.
Mechanistic
studies
indicate
involvement
chain-walking
process.
Gram-scale
reactions
various
product
derivatizations
further
highlight
its
practicality.
Язык: Английский
Cobalt-Catalyzed Remote Site-Selective Hydroboration of Unactivated Alkenes via Chain-Walking Strategy
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
An
expedient
synthesis
of
α-aminoboronic
acid
derivatives
via
cobalt-catalyzed
remote
site-selective
hydroboration
unactivated
alkenes
is
described
herein.
The
strategy
characterized
by
its
simplicity,
site-selectivity,
and
wide
substrate
scope,
as
both
terminal
internal
could
undergo
the
reaction
smoothly,
affording
corresponding
products
in
good
yields.
According
to
mechanism,
Co-H
generated
from
Co(acac)2
presence
HBpin,
which
starts
chain-walking
a
series
alkene
insertion
β-H
elimination
process.
Язык: Английский
Reaction Mechanism Study on Hydroboration and Dehydrogenative Borylation of Styrene Catalyzed by Co(II) Phosphinopyridonate Complex
Organometallics,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 19, 2025
Язык: Английский
Iron(I) and Iron(II) Boxmi Pincer Complexes: Coordination Chemistry and Catalytic Hydroboration of Nitriles
David Bürgy,
Clemens K. Blasius,
Tim Bruckhoff
и другие.
Organometallics,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 4, 2025
Язык: Английский
Cobalt-Catalyzed Enantioselective Reductive Addition of Ketimine with Cyclopropyl Chloride to Construct the Chiral Amino Esters Bearing Cyclopropyl Fragments
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(22), С. 6311 - 6318
Опубликована: Янв. 1, 2024
Co-catalyzed
asymmetric
reductive
addition
of
ketimine
with
cyclopropyl
chloride
has
been
realized
to
access
diverse
chiral
amino
esters
bearing
fragments
broad
functional
group
tolerance
and
excellent
enantioselectivities.
Язык: Английский
Hydrometallation of C C and C C Bonds. Group-3
Elsevier eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Cobalt-Catalyzed Three-Component Alkyl Arylation of Acrylates with Alkyl Iodides and Aryl Grignard Reagents
Organic Letters,
Год журнала:
2024,
Номер
26(43), С. 9288 - 9293
Опубликована: Окт. 21, 2024
A
highly
regioselective
cobalt-catalyzed
three-component
alkyl
arylation
of
acrylates
with
iodides
and
aryl
Grignard
reagents
has
been
established.
The
reaction
efficiently
provides
an
alternative
strategy
for
the
construction
α-aryl
esters
a
broad
substrate
scope
good
yields
under
mild
conditions.
practical
applicability
this
protocol
is
shown
by
scaled-up
further
transformations
products.
In
addition,
preliminary
mechanistic
explorations
demonstrated
that
radicals
generated
efficient
cobalt
catalysis
are
instantaneously
added
to
finally
afford
desired
Язык: Английский