Enantioselective Synthesis of vic-Aminoalcohol Derivatives by Nickel-Catalyzed Reductive Coupling of Aldehydes with Protected Amino-pentadienoates DOI Creative Commons

Thilo Bender,

Alois Fürstner

Journal of the American Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

A VAPOL-derived phosphoramidite ligand is uniquely effective at reverting the regiochemical course of nickel-catalyzed reactions aldehydes with carbamate-protected 5-amino-2,4-pentadienoates as "push/pull" dienes; ensuing carbonyl α-amino-homoallylation reaction affords

Язык: Английский

Highly Stereo- and Enantioselective Syntheses of δ-Alkyl-Substituted (Z)-Homoallylic Alcohols DOI Creative Commons
Ming Chen

Organic Letters, Год журнала: 2025, Номер 27(2), С. 612 - 617

Опубликована: Янв. 6, 2025

Highly stereo- and enantioselective synthesis of δ-alkyl-substituted (Z)-homoallylic alcohols via asymmetric allylation is developed. In the presence a chiral phosphoric acid catalyst, aldehydes with α-substituted allylboronates provides homoallylic excellent (Z)-selectivities enantioselectivities.

Язык: Английский

Процитировано

0
Nickel-Catalyzed Hydrocarbamoylation of Alkenes with Isocyanates DOI

Meng-Ying Qian,

Yuqing Wang, Qi‐Lin Zhou

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

The hydrocarbamoylation of alkenes with isocyanates is a promising method for synthesizing amides. However, applying this strategy to more inert, simple alkenes, such as styrenes, α-olefins, and internal poses significant challenges. Here, we report the first nickel-catalyzed isocyanates, facilitated by triethoxysilane reduce nickelacycle intermediates. By switching ligands─including 6,6′-dimethyl-2,2′-bipyridine N-heterocyclic carbene─this efficiently produces amides from diverse array including gaseous olefins.

Язык: Английский

Процитировано

0
Controllable Radical Reactions of 1,3-Dienes with Light DOI

Shiwei Lü,

Jin Xie

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 7749 - 7779

Опубликована: Апрель 25, 2025

Язык: Английский

Процитировано

0
Cobalt-Catalyzed Enantioselective Reductive Addition of Ketimine with Cyclopropyl Chloride to Construct the Chiral Amino Esters Bearing Cyclopropyl Fragments DOI
Jiangtao Hu, Tingting Xia, Xianqing Wu

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(22), С. 6311 - 6318

Опубликована: Янв. 1, 2024

Co-catalyzed asymmetric reductive addition of ketimine with cyclopropyl chloride has been realized to access diverse chiral amino esters bearing fragments broad functional group tolerance and excellent enantioselectivities.

Язык: Английский

Процитировано

1
Enantioselective Synthesis of vic-Aminoalcohol Derivatives by Nickel-Catalyzed Reductive Coupling of Aldehydes with Protected Amino-pentadienoates DOI Creative Commons

Thilo Bender,

Alois Fürstner

Journal of the American Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

A VAPOL-derived phosphoramidite ligand is uniquely effective at reverting the regiochemical course of nickel-catalyzed reactions aldehydes with carbamate-protected 5-amino-2,4-pentadienoates as "push/pull" dienes; ensuing carbonyl α-amino-homoallylation reaction affords

Язык: Английский

Процитировано

0