Unconventional Parahydrogen-Induced Hyperpolarization Effects in Chemistry and Catalysis: From Photoreactions to Enzymes
ACS Catalysis,
Год журнала:
2025,
Номер
unknown, С. 6386 - 6409
Опубликована: Апрель 4, 2025
Nuclear
spin
hyperpolarization
utilizing
parahydrogen
has
the
potential
for
broad
applications
in
chemistry,
catalysis,
biochemistry,
and
medicine.
This
review
examines
recent
chemical
biochemical
insights
gained
using
parahydrogen-induced
polarization
(PHIP).
We
begin
with
photoinduced
PHIP,
which
allows
investigation
of
short-lived
photoactivated
catalysis.
Next,
we
partially
negative
line
effect,
distinctive
shape
helps
to
reveal
information
about
rapid
exchange
role
catalytic
species.
The
NMR
signal
enhancement
a
single
proton
oneH-PHIP
is
discussed,
challenging
underpinning
concept
necessity
pairwise
hydrogenation.
Furthermore,
examine
metal-free
PHIP
facilitated
by
frustrated
Lewis
pair
molecular
tweezers
radicaloids,
demonstrating
alternative
routes
Although
symmetric
molecules
incorporating
are
silent,
showcase
methods
that
hyperpolarized
states
through
post-hydrogenation
reactions.
discuss
processes
mediate
transfer
between
target,
expanding
reach
without
synthesizing
specialized
precursors.
conclude
this
highlighting
uncovering
H2
activation
mechanisms
hydrogenases.
By
providing
detailed
these
diverse
phenomena,
aim
familiarize
reader
versatility
its
mechanistic
studies
analysis.
Язык: Английский
Parahydrogen Polarization in Reverse Micelles and Application to Sensing of Protein–Ligand Binding
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
A
medium
containing
reverse
micelles
supports
non-hydrogenative
parahydrogen
induced
polarization
(nhPHIP)
in
the
organic
phase
while
solubilizing
a
protein
aqueous
phase.
Strongly
enhanced
NMR
signals
from
iridium
hydride
complexes
report
on
ligand,
4-amino-2-benzylaminopyrimidine,
which
crosses
boundary
and
interacts
with
thiaminase
TenA.
The
calculation
of
binding
equilibria
reveals
Язык: Английский