Sulfur‐π Interaction: A New Strategy for Designing NIR‐II AIE Photosensitizer for Wound Healing DOI
Haifei Wen, Ziwei Deng, Ruihua Dong

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Abstract Noncovalent interactions (NCIs) play a pivotal role in tuning the photophysical properties of functional materials, yet their potential optimizing photosensitizers remains underexplored. In this study, molecular design strategy is presented that integrates sulfur‐π (S‐π) with aggregation‐induced emission (AIE) to enhance performance near‐infrared II (NIR‐II) for biomedical applications. Unlike conventional π‐π stacking, which often leads aggregation‐caused quenching (ACQ), S‐π provide directional packing without significant fluorescence quenching. Four AIE molecules (P‐THX, T‐THX, TP‐THX, and TT‐THX) are synthesized systematic phenyl‐to‐thiophene substitution modulate precisely. These lower singlet‐triplet energy gap (Δ E ST ), extend π‐conjugation, facilitate intersystem crossing (ISC), thereby boosting generation reactive oxygen species (ROS). Single‐crystal analysis revealed create continuous electronic coupling networks advantages over stacking arrangements. The thiophene‐substituted TT‐THX exhibits superior properties, demonstrating potent photodynamic antibacterial activity against Staphylococcus aureus ( S. ) methicillin‐resistant (MRSA). When formulated as nanoparticles, enables effective wound healing, underscoring therapeutic interaction‐engineered photosensitizers. This study establishes new paradigm, unlocking advanced NIR‐II phototheranostics strategies promising applications infection treatment, cancer therapy, biosensing.

Язык: Английский

Phenol[4]arenes: Excellent Macrocyclic Precursors for Constructing Chiral Porous Organic Cages DOI

Fenglei Qiu,

Xinting Zhang,

Wenjing Wang

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 2, 2025

The development of new chiral building blocks for constructing complex architectures, such as macrocycles and cages, is both crucial challenging. Although concave-shaped calixarenes have been established versatile the synthesis cage compounds, there are no reports on cages constructed from calix[4]arene derivatives. Herein, we present a straightforward effective method gram-scale member macrocycle enantiomers, namely, phenol[4]arene (PC[4]A). As proof concept, functionalized these enantiomers into tetraformylphenol[4]arene (PC[4]ACHO) derivatives via Duff reaction to construct porous organic (CPOCs) using polyamine synthons. Specifically, employ two fluorescent amine synthons, bis(4-aminophenyl)phenylamine tris(4-aminophenyl)amine, assemble with PC[4]ACHO resulting in [2 + 4] lantern-shaped [6 8] truncated octahedral CPOCs, respectively. These structures unambiguously characterized by single-crystal X-ray diffraction circular dichroism (CD) spectroscopy. Notably, CPOCs exhibit internal diameters approximately 3.1 nm, cavity volume around 5300 Å3, high specific surface areas up 1300 m2 g-1 after desolvation, making them among largest reported. Additionally, investigations their sensing performance demonstrate that PC[4]A-based enable enantioselective recognition amino acids This work strongly suggests PC[4]A can serve an excellent block rational design materials practical applications.

Язык: Английский

Процитировано

3
Reversible Switching and Recycling of Thermoresponsive 1,2,4-Triazolium-Based Poly(ionic liquid) Catalysts for Porous Organic Cage Synthesis in Organic Media DOI Creative Commons

Jiefeng Zhu,

Feng Chen, Mingjie Zhang

и другие.

ACS Macro Letters, Год журнала: 2025, Номер unknown, С. 458 - 463

Опубликована: Март 23, 2025

Homogeneous catalysts of high activity and selectivity often face challenges in the separation from feedstocks products after reactions. In contrast, heterogeneous are easier to separate, usually at cost compromised catalytic performance. By designing capable switching between homogeneous states for catalysis separation, merits both could be synergistically combined. this study, a thermoresponsive 1,2,4-triazolium-based poly(ionic liquid) (PIL) was applied as temperature-switchable organocatalyst controlled synthesis porous organic cages methanol. Variation reaction temperature induced phase transition PIL, causing polymer chains dissolve or collapse methanol, thereby exposing shielding catalytically active sites proceed retard reaction, respectively. To note, sufficiently low temperature, PIL catalyst precipitated out its methanol solution separated by centrifugation filtration reuse, similar common catalysts. Such switchable recyclable properties polymeric will inspire design efficient adaptable hybrid nanoreactors liquid media.

Язык: Английский

Процитировано

1
Boosting porphyrin photocatalysis in thiophenol cross-coupling via supramolecular host-guest engineering DOI

Guang-Lu Li,

Xuan‐Zong Yang,

Rongxin Zhu

и другие.

Dyes and Pigments, Год журнала: 2025, Номер 240, С. 112860 - 112860

Опубликована: Апрель 28, 2025

Язык: Английский

Процитировано

0
Sulfur‐π Interaction: A New Strategy for Designing NIR‐II AIE Photosensitizer for Wound Healing DOI
Haifei Wen, Ziwei Deng, Ruihua Dong

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Abstract Noncovalent interactions (NCIs) play a pivotal role in tuning the photophysical properties of functional materials, yet their potential optimizing photosensitizers remains underexplored. In this study, molecular design strategy is presented that integrates sulfur‐π (S‐π) with aggregation‐induced emission (AIE) to enhance performance near‐infrared II (NIR‐II) for biomedical applications. Unlike conventional π‐π stacking, which often leads aggregation‐caused quenching (ACQ), S‐π provide directional packing without significant fluorescence quenching. Four AIE molecules (P‐THX, T‐THX, TP‐THX, and TT‐THX) are synthesized systematic phenyl‐to‐thiophene substitution modulate precisely. These lower singlet‐triplet energy gap (Δ E ST ), extend π‐conjugation, facilitate intersystem crossing (ISC), thereby boosting generation reactive oxygen species (ROS). Single‐crystal analysis revealed create continuous electronic coupling networks advantages over stacking arrangements. The thiophene‐substituted TT‐THX exhibits superior properties, demonstrating potent photodynamic antibacterial activity against Staphylococcus aureus ( S. ) methicillin‐resistant (MRSA). When formulated as nanoparticles, enables effective wound healing, underscoring therapeutic interaction‐engineered photosensitizers. This study establishes new paradigm, unlocking advanced NIR‐II phototheranostics strategies promising applications infection treatment, cancer therapy, biosensing.

Язык: Английский

Процитировано

0