Targeting pyroptosis for cancer immunotherapy: mechanistic insights and clinical perspectives DOI Creative Commons
Chen Huang, Jiayi Li, Ruiyan Wu

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Май 3, 2025

Pyroptosis is a distinct form of programmed cell death characterized by the rupture membrane and robust inflammatory responses. Increasing evidence suggests that pyroptosis significantly affects tumor microenvironment antitumor immunity releasing damage-associated molecular patterns (DAMPs) pro-inflammatory mediators, thereby establishing it as pivotal target in cancer immunotherapy. This review thoroughly explores mechanisms underlying pyroptosis, with particular focus on inflammasome activation gasdermin family proteins (GSDMs). It examines role pyroptotic reshaping immune (TIME) involving both cells, discusses recent advancements targeting pathways through therapeutic strategies such small molecule modulators, engineered nanocarriers, combinatory treatments checkpoint inhibitors. We also advances future directions to enhance immunotherapy inhibitors, adoptive therapy, vaccines. study suggested offers promising avenue amplify responses surmount resistance existing immunotherapies, potentially leading more efficacious treatments.

Язык: Английский

Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis DOI Creative Commons

Miao-Yan Xu,

Jie Zeng,

Xin-Hao Han

и другие.

Materials & Design, Год журнала: 2025, Номер unknown, С. 113647 - 113647

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Inorganic Nanobiomaterials Boost Tumor Immunotherapy: Strategies and Applications DOI
Qi Meng, Binbin Ding,

Ping’an Ma

и другие.

Accounts of Chemical Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

ConspectusTumor immunotherapy, as a new antitumor method to fight cancer by activating or enhancing the body's own immune system, has been extensively studied and applied in clinical practice. However, an extremely complex tumor heterogeneity immunosuppressive microenvironment (TME) lead poor response rate secondary drug resistance. The advent of nanotechnology ushered era for immunotherapy. In particular, inorganic nanomaterials, with their unique physicochemical properties excellent biocompatibility, are becoming important tool Inorganic nanomaterials can be used carriers agents, improving delivery efficiency thereby reducing systemic immunotoxicity responses. also trigger immunogenic cell death (ICD), stimulate responses, alleviate TME increasing oxygen levels, modulating metabolic pathways, altering secretion cytokines. synergistic integration immunotherapy adeptly navigates around constraints conventional treatments, side effects while concurrently augmenting therapeutic efficacy. this review, we summarize our recent efforts design synthesis nanobiomaterials enhance efficacy These achieve desired mainly through four strategies, including inducing ICD, developing nanovaccines, pyroptosis, regulating metabolism, providing beneficial implications For one thing, due deficiency ICD effect single therapy, developed nanocatalysts that integrate multiple functions play catalytic role TME, converting substances metabolites into products situ, further ICD. another, order solve problems low antigen loading existing adjuvants, several novel multifunctional nanoadjuvants were prepared, which combine high multimode function one, efficient activation. Moreover, attain strong inflammatory responses immunogenicity, engineer pyroptosis adjuvants selectively induce intracellular oxidative stress ion overload. Finally, reverse microenvironment, nanoplatforms target levels nutrients such glucose, lactic acid, citric tryptophan effectively alter response. implementation these strategies not only improves but reduces provides valuable insights references development assist

Язык: Английский

Процитировано

0
Gallium‐Magnesium Layered Double Hydroxide for Elevated Tumor Immunotherapy Through Multi‐Network Synergistic Regulation DOI
Jia Tan, Binbin Ding, Hao Chen

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Abstract Immunotherapeutic efficacy is often limited by poor immunogenicity, immunosuppressive tumor microenvironment (TME), and cytoprotective mechanisms, leading to low immune activation. To this end, here, L‐amino acid oxidase (LAAO) loaded gallium‐magnesium layered double hydroxide (MG‐LAAO) prepared for significantly enhanced immunotherapy through multi‐network synergistic regulation. First, MG‐LAAO induces cell pyroptosis initiating caspase‐1/GSDMD caspase‐3/GSDME pathways, further triggering immunogenic death (ICD). Then the released Ga 3+ mitochondrial iron overload, resulting in ferroptosis. In addition, also hinders autophagy of cells, reshapes (TME) neutralizing H + inhibiting lactic accumulation, thus destroying mechanism avoiding escape. Furthermore, synergy activates cGAS‐STING signaling pathway, generating powerful antitumor immunotherapy. This work highlights critical role synergies between block, pyroptosis, ferroptosis, ICD immunotherapy, demonstrating important effectively overcoming TME enhancing immunogenicity. particular, gallium‐induced revealed first time, providing theoretical support design new materials future.

Язык: Английский

Процитировано

0
Targeting pyroptosis for cancer immunotherapy: mechanistic insights and clinical perspectives DOI Creative Commons
Chen Huang, Jiayi Li, Ruiyan Wu

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Май 3, 2025

Pyroptosis is a distinct form of programmed cell death characterized by the rupture membrane and robust inflammatory responses. Increasing evidence suggests that pyroptosis significantly affects tumor microenvironment antitumor immunity releasing damage-associated molecular patterns (DAMPs) pro-inflammatory mediators, thereby establishing it as pivotal target in cancer immunotherapy. This review thoroughly explores mechanisms underlying pyroptosis, with particular focus on inflammasome activation gasdermin family proteins (GSDMs). It examines role pyroptotic reshaping immune (TIME) involving both cells, discusses recent advancements targeting pathways through therapeutic strategies such small molecule modulators, engineered nanocarriers, combinatory treatments checkpoint inhibitors. We also advances future directions to enhance immunotherapy inhibitors, adoptive therapy, vaccines. study suggested offers promising avenue amplify responses surmount resistance existing immunotherapies, potentially leading more efficacious treatments.

Язык: Английский

Процитировано

0