Copper-Catalyzed Stereoselective Cyanation/Phosphorylation of Formamides with TMSCN and P(O)–H Bonds DOI
Weifeng Xu,

Liyong Fan,

Zikang Li

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 12, 2025

A novel copper-catalyzed approach for the stereoselective cyanation and phosphorylation of formamides has been developed. This protocol enables direct conversion a broad range agents, including H-phosphonates, H-phosphinates, H-phosphine oxides, into target cyanation/phosphorylation products with good to excellent yields. Notably, when optically active H-phosphinates are employed, transformation exhibits exceptional stereoselectivity. In combination DFT calculation systematic step-by-step control experiments, possible reaction mechanism is proposed.

Язык: Английский

Enantioselective modular synthesis of α-aryl-α-heteroaryl aminonitriles with parts per million organocatalyst loading: mechanistic investigation for stereochemical origins DOI

Yusuke Oyamada,

Kazuki Ishikawa, Tsunayoshi Takehara

и другие.

Organic Chemistry Frontiers, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

An enantioselective Friedel-Crafts reaction of iminonitriles gave chiral α-aryl-α-heteroarylaminonitriles in high yield with good enantioselectivity. Pyrrole and indole additions produced different stereochemistries under the same catalyst, explained by DFT.

Язык: Английский

Процитировано

0
Copper-Catalyzed Stereoselective Cyanation/Phosphorylation of Formamides with TMSCN and P(O)–H Bonds DOI
Weifeng Xu,

Liyong Fan,

Zikang Li

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 12, 2025

A novel copper-catalyzed approach for the stereoselective cyanation and phosphorylation of formamides has been developed. This protocol enables direct conversion a broad range agents, including H-phosphonates, H-phosphinates, H-phosphine oxides, into target cyanation/phosphorylation products with good to excellent yields. Notably, when optically active H-phosphinates are employed, transformation exhibits exceptional stereoselectivity. In combination DFT calculation systematic step-by-step control experiments, possible reaction mechanism is proposed.

Язык: Английский

Процитировано

0