Emerging Trends in DNA Nanotechnology-Enabled Cell Surface Engineering

JACS Au, Год журнала: 2025, Номер 5(2), С. 550 - 570

Опубликована: Фев. 6, 2025

Cell surface engineering is a rapidly advancing field, pivotal for understanding cellular physiology and driving innovations in biomedical applications. In this regard, DNA nanotechnology offers unprecedented potential precisely manipulating functionalizing cell surfaces by virtue of its inherent programmability versatile functionalities. Herein, Perspective provides comprehensive overview emerging trends engineering, focusing on key nanostructure-based tools, their roles regulating physiological processes, We first discuss the strategies integrating molecules onto surfaces, including attachment oligonucleotides higher-order nanostructure. Second, we summarize impact DNA-based various such as membrane protein degradation, signaling transduction, intercellular communication, construction artificial components. Third, highlight applications DNA-engineered targeted therapies cancer inflammation, well capture/protection diagnostic detection. Finally, address challenges future directions nanotechnology-based engineering. This aims to provide valuable insights rational design contributing development precise personalized medicine.

Язык: Английский

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Multivalent DNA lysosome-targeting chimaera for targeted protein degradation and inhibition of c-Met signaling pathways

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161974 - 161974

Опубликована: Март 1, 2025

Язык: Английский

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Recent Advances in DNA‐Templated Protein Patterning

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

Abstract In recent decades, the advancement of DNA nanotechnology enables precise nanoscale organization diverse functional materials with templates. Particularly, a variety DNA‐templated protein patterns are constructed as powerful tools for programming biomimetic complexes. this review, progress in patterning, including cutting‐edge methods arranging proteins templates, and across varying dimensions briefly summarized. Representative applications biological analysis biomedicine discussed. DNA‐protein programmable dynamics, which hold promise precision diagnosis therapeutics highlighted. Finally, current challenges opportunities fabrication application pattering

Язык: Английский

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A membrane-protein targeted DNA multitasking processor for precise tumor cell imaging

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137667 - 137667

Опубликована: Март 1, 2025

Язык: Английский

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DNA Nanostructures for Rational Regulation of Cellular Organelles

JACS Au, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

DNA nanotechnology has revolutionized materials science and biomedicine by enabling precise manipulation of matter at the nanoscale. nanostructures (DNs) in particular represent a promising frontier for targeted therapeutics. Engineered DNs offer unprecedented molecular programmability, biocompatibility, structural versatility, making them ideal candidates advanced drug delivery, organelle regulation, cellular function modulation. This Perspective explores emerging role modulating behavior through organelle-targeted interventions. We highlight current advances nuclear, mitochondrial, lysosomal targeting, showcasing applications ranging from gene delivery to cancer For instance, have enabled precision mitochondrial disruption cells, pH modulation enhance silencing, nuclear gene-editing templates. While hold immense promise advancing nanomedicine, outstanding challenges include optimizing biological interactions addressing safety concerns. highlights potential rational control organelles, which could lead novel therapeutic strategies advancement nanomedicines future.

Язык: Английский

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Unlocking New Frontiers in Cell Signaling and Communication and Fostering New Collaborative Interactions and Scientific Initiatives: Lessons Learned from the International Cellular Communication Network Society (ICCNS) Workshop

Опубликована: Апрель 15, 2025

Язык: Английский

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Editorial: Environmentally-responsive biomaterials for major diseases treatment

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 25, 2025

Язык: Английский

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Recent advances in degraders engaging lysosomal pathways and related nanomedicine

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 292, С. 117701 - 117701

Опубликована: Апрель 28, 2025

Язык: Английский

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Targeted degradation of extracellular proteins: state of the art and diversity of degrader designs

Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)

Опубликована: Май 1, 2025

Язык: Английский

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