Manganese(I)-Catalyzed Enantioselective Alkylation To Access P-Stereogenic Phosphines
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
This
work
introduces
a
novel
Mn(I)-catalyzed
enantioselective
alkylation
methodology
that
efficiently
produces
wide
array
of
P-chiral
phosphines
with
outstanding
yields
and
enantioselectivities.
Notably,
the
exceptional
reactivity
Mn(I)
complexes
in
these
reactions
is
demonstrated
by
their
effective
catalysis
both
typically
reactive
alkyl
iodides
bromides,
as
well
less
chlorides.
approach
broadens
accessibility
to
various
simplifies
synthesis
chiral
tridentate
pincer
concise
1–2
step
process,
contrary
conventional,
labor-intensive
multistep
procedures.
Importantly,
development
significantly
expands
applicability
earth-abundant
Mn(I)-based
beyond
recently
established
roles
catalytic
hydrogenative
conjugate
addition
reactions,
emphasizing
potential
viable
alternative
noble
metal
chemistry
and,
some
cases,
even
surpassing
performance.
Язык: Английский
Recent Advances in Transition Metal‐Catalyzed Asymmetric Synthesis of P‐chiral Organophosphorus Compounds (2020–Present)
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 3, 2025
Comprehensive
Summary
P
‐chiral
organophosphorus
compounds
have
demonstrated
unparalleled
application
potential
in
diverse
fields,
including
medicine,
agricultural
science,
material
and
life
science.
Furthermore,
they
serve
as
highly
effective
chiral
ligands
both
transition
metal‐catalyzed
organocatalytic
asymmetric
transformations.
In
recent
years,
significant
advances
been
made
the
catalytic
synthesis
of
compounds,
with
phosphination
hydrophosphination
reactions
emerging
dominant
strategies.
This
review
systematically
summarizes
methodological
developments
from
2020
to
present
for
constructing
compounds.
The
discussion
is
organized
according
different
metals,
aiming
provide
a
valuable
reference
inspiration
researchers
organic
chemistry.
Key
Scientists
Язык: Английский