A Chemical Investigation Approach of Paraconiothyrium sp. FKR‐0637 Fungal Strain Enables the Isolation of New Chlorinated Chromone, Nohocumone DOI Open Access

Haruki Azami,

Yoshihiro Watanabe,

Takahito Ouchi

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(9)

Опубликована: Фев. 28, 2025

Abstract The discovery of novel natural products (NPs) from diverse microorganisms is essential for advancing drug discovery. In this study, a chemical investigation approach was employed NP exploration using the genus Paraconiothyrium sp. isolated root soil Ficus microcarpa on Noho Island, Okinawa. Consequently, we five compounds, including new chromone, nohocumone ( 1 ), as well four known chromone 2 10‐norparvulenone 3 sclerotinin A 4 and calbistrin 5 culture broth FKR‐0637. planar structure elucidated 1D 2D NMR analyses, HR‐ESIMS, derivatization. Chlorinated compound that not previously These results expand structural diversity collection NPs obtained

Язык: Английский

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Robert A. Hill, Andrew Sutherland

Natural Product Reports, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A personal selection of 32 recent papers is presented covering various aspects current developments in bioorganic chemistry and novel natural products, such as hyperzrone from Hypericum beanii .

Язык: Английский

Процитировано

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A Chemical Investigation Approach of Paraconiothyrium sp. FKR‐0637 Fungal Strain Enables the Isolation of New Chlorinated Chromone, Nohocumone DOI Open Access

Haruki Azami,

Yoshihiro Watanabe,

Takahito Ouchi

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(9)

Опубликована: Фев. 28, 2025

Abstract The discovery of novel natural products (NPs) from diverse microorganisms is essential for advancing drug discovery. In this study, a chemical investigation approach was employed NP exploration using the genus Paraconiothyrium sp. isolated root soil Ficus microcarpa on Noho Island, Okinawa. Consequently, we five compounds, including new chromone, nohocumone ( 1 ), as well four known chromone 2 10‐norparvulenone 3 sclerotinin A 4 and calbistrin 5 culture broth FKR‐0637. planar structure elucidated 1D 2D NMR analyses, HR‐ESIMS, derivatization. Chlorinated compound that not previously These results expand structural diversity collection NPs obtained

Язык: Английский

Процитировано

0