Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

Subtle structural variations among fatty acids significantly influence their biological roles and health effects. However, molecular recognition of long, flexible, chemically inert hydrocarbon chains remains a challenge. Inspired by natural acid-binding proteins (FABPs), we designed synthesized nanotubular metallo-cavitands, termed metal-organic pillars, through the coordination-driven assembly pillararene-derived ligands with Ag(I) salts. These biomimetic hosts feature continuous interior channels exceeding 2.6 nm, selectively binding long-chain precise size shape complementarity. Saturated trans acids, linear conformations, are effectively encapsulated stabilized C-H···π van der Waals interactions. In contrast, coiled cis-polyunsaturated such as docosahexaenoic acid (DHA), cannot be accommodated due to incompatibility. This work highlights ability artificial receptors emulate capabilities proteins, enabling targeting "bad" associated adverse

Язык: Английский