A Mitochondria-Targeted Dye for Investigating Mo Mineral Powder Induced Cytotoxicity through SIM Super-Resolution Imaging DOI
Lai Wang,

Zhiqi Su,

Daqing Ma

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Heavy metal substances are known to do great harm human beings. However, the mechanism of heavy-metal-induced toxicity at cellular level is currently unclear. In this study, we developed a series mitochondria-targeted fluorescence probes (KRhs) explore structural and environmental changes in mitochondria upon treatment molybdenum mineral powders by using SIM super-resolution imaging. These designed tuning lengths alkyl chains within NIR xanthene dye strengthen self-assembly characteristics, thereby optimizing targeting stability toward signal-to-noise ratio We applied KRh-C16 for imaging cells treated with various (Mo) found morphology single mitochondrion during molybdenum-induced autophagy high-resolution further identified generation reactive oxygen species damage. results help us understand heavy mining industry. Generally, study provides promising tool technique investigating mitochondria-related cytotoxicity.

Язык: Английский

A Mitochondria-Targeted Dye for Investigating Mo Mineral Powder Induced Cytotoxicity through SIM Super-Resolution Imaging DOI
Lai Wang,

Zhiqi Su,

Daqing Ma

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Heavy metal substances are known to do great harm human beings. However, the mechanism of heavy-metal-induced toxicity at cellular level is currently unclear. In this study, we developed a series mitochondria-targeted fluorescence probes (KRhs) explore structural and environmental changes in mitochondria upon treatment molybdenum mineral powders by using SIM super-resolution imaging. These designed tuning lengths alkyl chains within NIR xanthene dye strengthen self-assembly characteristics, thereby optimizing targeting stability toward signal-to-noise ratio We applied KRh-C16 for imaging cells treated with various (Mo) found morphology single mitochondrion during molybdenum-induced autophagy high-resolution further identified generation reactive oxygen species damage. results help us understand heavy mining industry. Generally, study provides promising tool technique investigating mitochondria-related cytotoxicity.

Язык: Английский

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