Sulfur‐π Interaction: A New Strategy for Designing NIR‐II AIE Photosensitizer for Wound Healing DOI
Haifei Wen, Ziwei Deng, Ruihua Dong

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Abstract Noncovalent interactions (NCIs) play a pivotal role in tuning the photophysical properties of functional materials, yet their potential optimizing photosensitizers remains underexplored. In this study, molecular design strategy is presented that integrates sulfur‐π (S‐π) with aggregation‐induced emission (AIE) to enhance performance near‐infrared II (NIR‐II) for biomedical applications. Unlike conventional π‐π stacking, which often leads aggregation‐caused quenching (ACQ), S‐π provide directional packing without significant fluorescence quenching. Four AIE molecules (P‐THX, T‐THX, TP‐THX, and TT‐THX) are synthesized systematic phenyl‐to‐thiophene substitution modulate precisely. These lower singlet‐triplet energy gap (Δ E ST ), extend π‐conjugation, facilitate intersystem crossing (ISC), thereby boosting generation reactive oxygen species (ROS). Single‐crystal analysis revealed create continuous electronic coupling networks advantages over stacking arrangements. The thiophene‐substituted TT‐THX exhibits superior properties, demonstrating potent photodynamic antibacterial activity against Staphylococcus aureus ( S. ) methicillin‐resistant (MRSA). When formulated as nanoparticles, enables effective wound healing, underscoring therapeutic interaction‐engineered photosensitizers. This study establishes new paradigm, unlocking advanced NIR‐II phototheranostics strategies promising applications infection treatment, cancer therapy, biosensing.

Язык: Английский

Core-Substituted Pyromellitic Diimides: A Versatile Molecular Scaffold for Tunable Triplet Emission DOI
Sopan M. Wagalgave,

Anju Ajayan Kongasseri,

U.P. Singh

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Arylene diimides represent a versatile class of n-type organic semiconductors, widely recognized for tunable photophysical properties, making them highly relevant across various optoelectronic applications. While their fluorescence can be finely modulated through core substitution, triplet-state emission has received comparatively little attention. This is particularly surprising given the growing field ambient-organic triplet harvesting materials, such as thermally activated delayed and phosphorescent systems, which would greatly benefit from structural modifications to π-conjugated backbone substitution arylene achieve desired properties. Realizing states within family molecules crucial advancing triplet-based materials applications in lighting, photocatalysis, beyond. In this context, we present an unprecedented study demonstrating pyromellitic diimides, smallest member diimide family, with accessible emissive state due narrow singlet-triplet energy gap. Herein, report synthesis series core-substituted (cPmDIs) using diverse synthetic strategies. Core not only induces wide spectrum colors but, notably, enables wide-range phosphorescence spanning visible spectrum, depending on substituent. article details electrochemical characterization library cPmDIs, supported by theory. Furthermore, demonstrate potential molecular design achieving ambient-orange phosphorescence, exemplified thiophenyl-cPmDI derivative, exhibits crystalline film minimizing vibrational dissipation. regard, envision that represents significant step toward predictive structure-property phosphors materials.

Язык: Английский

Процитировано

0
Sulfur‐π Interaction: A New Strategy for Designing NIR‐II AIE Photosensitizer for Wound Healing DOI
Haifei Wen, Ziwei Deng, Ruihua Dong

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Abstract Noncovalent interactions (NCIs) play a pivotal role in tuning the photophysical properties of functional materials, yet their potential optimizing photosensitizers remains underexplored. In this study, molecular design strategy is presented that integrates sulfur‐π (S‐π) with aggregation‐induced emission (AIE) to enhance performance near‐infrared II (NIR‐II) for biomedical applications. Unlike conventional π‐π stacking, which often leads aggregation‐caused quenching (ACQ), S‐π provide directional packing without significant fluorescence quenching. Four AIE molecules (P‐THX, T‐THX, TP‐THX, and TT‐THX) are synthesized systematic phenyl‐to‐thiophene substitution modulate precisely. These lower singlet‐triplet energy gap (Δ E ST ), extend π‐conjugation, facilitate intersystem crossing (ISC), thereby boosting generation reactive oxygen species (ROS). Single‐crystal analysis revealed create continuous electronic coupling networks advantages over stacking arrangements. The thiophene‐substituted TT‐THX exhibits superior properties, demonstrating potent photodynamic antibacterial activity against Staphylococcus aureus ( S. ) methicillin‐resistant (MRSA). When formulated as nanoparticles, enables effective wound healing, underscoring therapeutic interaction‐engineered photosensitizers. This study establishes new paradigm, unlocking advanced NIR‐II phototheranostics strategies promising applications infection treatment, cancer therapy, biosensing.

Язык: Английский

Процитировано

0