Copper-Catalyzed Formal Aldehydic C–H Borylation Enabled by an sp2–sp3 Diboron Reagent DOI
Jiaxin Lin, Peiqi Zhang,

Xiangyu Lou

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

We have developed a copper-catalyzed formal aldehydic C-H borylation using neutral sp2-sp3 diboron reagent, LBH2-Bpin (where L is σ-donor), leading to the one-pot synthesis of diverse acylboranes. Notably, BH moieties in acylborane can be further used construct boracycles. This protocol enables straightforward functional group (FG) replacement commercial medicines with an acylboron motif. Detailed mechanistic studies and DFT calculations reveal synergistic hydride transfer pathway, which promoted by electron-rich nature LBH2 fragment. investigation highlights potential new reagent accessing reaction modes that were previously unachievable.

Язык: Английский

Copper-Catalyzed Formal Aldehydic C–H Borylation Enabled by an sp2–sp3 Diboron Reagent DOI
Jiaxin Lin, Peiqi Zhang,

Xiangyu Lou

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

We have developed a copper-catalyzed formal aldehydic C-H borylation using neutral sp2-sp3 diboron reagent, LBH2-Bpin (where L is σ-donor), leading to the one-pot synthesis of diverse acylboranes. Notably, BH moieties in acylborane can be further used construct boracycles. This protocol enables straightforward functional group (FG) replacement commercial medicines with an acylboron motif. Detailed mechanistic studies and DFT calculations reveal synergistic hydride transfer pathway, which promoted by electron-rich nature LBH2 fragment. investigation highlights potential new reagent accessing reaction modes that were previously unachievable.

Язык: Английский

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