Catalytic applications of enzymes encapsulated in metal–organic frameworks

Coordination Chemistry Reviews, Год журнала: 2018, Номер 381, С. 151 - 160

Опубликована: Дек. 11, 2018

Язык: Английский

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2D Covalent Organic Frameworks for Biomedical Applications

Advanced Functional Materials, Год журнала: 2020, Номер 30(27)

Опубликована: Апрель 29, 2020

Abstract Covalent organic frameworks (COFs) are an emerging class of crystalline polymers with well‐defined molecular geometry and tunable porosity. COFs formed via reversible condensation lightweight building blocks, which dictate its in two or three dimensions. Among COFs, 2D have garnered special attention due to their unique structure composed two‐dimensionally extended sheets stacked layers generating periodic columnar π‐arrays, functional pore space, ease synthesis. These features combination low density, high crystallinity, large surface area, biodegradability made them excellent candidate for a plethora applications ranging from energy biomedical sciences. In this article, the evolution is briefly discussed terms different types chemical linkages, synthetic strategies bulk nanoscale tunability perspective. Next, specifically drug delivery, phototherapy, biosensing, bioimaging, biocatalysis, antibacterial activity summarized. addition, current challenges approaches designing advanced discussed.

Язык: Английский

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Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy

Angewandte Chemie International Edition, Год журнала: 2019, Номер 58(40), С. 14213 - 14218

Опубликована: Июль 26, 2019

Covalent organic frameworks (COFs) with 2D π-conjugation were designed and synthesized as molecular photosensitizers for efficient photodynamic therapy. Two molecules, 5',5''''-(1,4-phenylene)bis(([1,1':3',1''-terphenyl]-4,4''-dicarbaldehyde)) (L-3C) 4,4',4''-(1,4-phenylene)bis(([2,2':6',2''-terpyridine]-5,5''-dicarbaldehyde)) (L-3N), inactive to generating reactive oxygen species (ROS), linked form two COFs, COF-808 COF-909, respectively, exhibiting excellent ROS production efficiency. The high permanent porosity of these COFs (surface areas 2270 2610 m2 g-1 ) promoted diffusion both release in cells. This, combined the photostability biocompatibility, led PDT performance. In vitro, over 80 % tumor cells killed after treatment using COF-909 at concentration 50 μg mL-1 150 s. vivo, drastic reduction size was observed (from 9 mm less than 1 mm) 10 day treatment.

Язык: Английский

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Three-Dimensional Covalent Organic Frameworks: From Topology Design to Applications

Accounts of Chemical Research, Год журнала: 2020, Номер 53(10), С. 2225 - 2234

Опубликована: Сен. 8, 2020

ConspectusCovalent organic frameworks (COFs) represent a novel type of crystalline porous polymers with potential applications in many areas. Considering their covalent connectivity different dimensions, COFs are classified as two-dimensional (2D) layered structures or three-dimensional (3D) networks. In particular, 3D have gained increasing attention recently because remarkably large surface areas (>5000 m2/g), hierarchical nanopores and numerous open sites. However, it has been proven to be major challenge construct COFs, the main driving force for synthesis comes from formation bonds. addition, there several stones on roads blocking development COFs. First, successful topology design strategies limited [4 + 2] 3] condensation reactions tetrahedral molecules linear triangular building blocks first decade, which led only three available topologies (ctn, bor, dia) strongly restricted incorporation some important functional units. Next, is very challenging obtain large-size single crystals same may yield possible that quite difficult identify simulations, structure determination considered issue. Last, utilized synthesize limited, further affects functionalization applications. Therefore, since was announced 2007, research studies regarding underexplored years, few examples reported.To confront these obstacles we started contributing this field 2016. interesting quadrilateral (e.g., pyrene porphyrin) cannot easily derivatized into motifs, developed strategy via 4] blocks. After trials, found general synthetic build new pts topology. explored polycrystalline prepared by our electron diffraction technique. Moreover, expanded toolbox molecular creating successfully demonstrated characteristic properties Account, summarize above ongoing contributions, including (i) COFs; (ii) attempts determine crystal atomic resolution; (iii) diversification functionalized Overall, not offer paradigm expansion block families but also provide an idea future opportunities relevant researchers field.

Язык: Английский

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Covalent organic frameworks as multifunctional materials for chemical detection

Chemical Society Reviews, Год журнала: 2021, Номер 50(24), С. 13498 - 13558

Опубликована: Янв. 1, 2021

Sensitive and selective detection of chemical biological analytes is critical in various scientific technological fields. As an emerging class multifunctional materials, covalent organic frameworks (COFs) with their unique properties modularity, large surface area, high stability, low density, tunable pore sizes functionalities, which together define programmable properties, show promise advancing detection. This review demonstrates the recent progress where COFs constitute integral component achieved function. highlights how can be harnessed to develop different types systems based on principles chromism, luminescence, electrical transduction, chromatography, spectrometry, others achieve highly sensitive analytes, ranging from gases, volatiles, ions, biomolecules. The key parameters performance for target are summarized, compared, analyzed perspective mechanism structure-property-performance correlations COFs. Conclusions summarize current accomplishments analyze challenges limitations that exist under mechanisms. Perspectives future directions research advance COF-based through innovation novel COF design synthesis, device fabrication, exploration modes also discussed.

Язык: Английский

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