Chemical Reviews,
Год журнала:
2021,
Номер
121(22), С. 14281 - 14347
Опубликована: Май 4, 2021
Self-assembly
is
promising
for
construction
of
a
wide
variety
supramolecular
assemblies,
whose
1D/2D/3D
structures
are
typically
relevant
to
their
functions.
In-depth
understanding
structure–function
relationships
essential
rational
design
and
development
functional
molecular
assemblies.
Microscopic
imaging
has
been
used
as
powerful
tool
elucidate
individual
assemblies
with
subnanometer
millimeter
resolution,
which
complementary
conventional
spectroscopic
techniques
that
provide
the
ensemble
structural
information.
In
this
review,
we
highlight
representative
examples
visualization
by
use
electron
microscopy,
atomic
force
confocal
super-resolution
microscopy.
This
review
comprehensively
describes
nanofibers/gels,
micelles/vesicles,
coacervate
droplets,
polymer
protein/DNA
Advanced
can
address
key
challenges,
like
evaluation
dynamics
multicomponent
self-assembly,
self-assembly/disassembly
in
complex
cellular
milieu,
also
discussed.
We
believe
would
guidelines
deeper
analyses
develop
next-generation
materials.
Advanced Materials,
Год журнала:
2019,
Номер
31(11)
Опубликована: Янв. 21, 2019
Abstract
Chemotherapy
has
been
validated
unavailable
for
treatment
of
renal
cell
carcinoma
(RCC)
in
clinic
due
to
its
intrinsic
drug
resistance.
Sensitization
chemo‐drug
response
plays
a
crucial
role
RCC
and
increase
patient
survival.
Herein,
recognition‐reaction‐aggregation
(RRA)
cascaded
strategy
is
utilized
situ
construct
peptide‐based
superstructures
on
the
cancer
membrane,
enabling
specifically
perturbing
permeability
membranes
enhancing
sensitivity
vitro
vivo.
First,
P1‐DBCO
can
recognize
cells
by
targeting
carbonic
anhydrase
IX.
Subsequently,
P2‐N
3
introduced
efficiently
reacts
with
form
peptide
P3,
which
exhibits
enhanced
hydrophobicity
simultaneously
aggregates
into
superstructure.
Interestingly,
superstructure
retains
membrane
perturbs
integrity/permeability,
allowing
more
doxorubicin
(DOX)
uptaken
cells.
Owing
this
increased
influx,
IC
50
significantly
reduced
nearly
3.5‐fold
compared
that
treated
free
DOX.
Finally,
RRA
inhibits
tumor
growth
xenografted
mice
3.2‐fold
inhibition
rate
In
summary,
newly
developed
will
open
new
avenue
chemically
engineering
diverse
biomedical
applications.
Angewandte Chemie International Edition,
Год журнала:
2019,
Номер
58(46), С. 16601 - 16609
Опубликована: Авг. 30, 2019
Abstract
Activatable
photosensitizers
(aPSs)
sensitive
to
specific
stimuli
hold
potential
for
targeting
multiple
disease
biomarkers
and
are
desirable
photodynamic
therapy
(PDT).
Presented
herein
is
the
design
of
aPSs
that
can
be
activated
fully
recover
from
an
inhibited
state
in
presence
biomarker.
A
designed
long‐wavelength
D‐π‐A
photosensitizer,
PS
Se‐I
,
with
highly
efficient
photosensitivity
generation
1
O
2
was
used.
Caging
phenolate
donor
a
biomarker‐sensitive
group
provided
ALP
drastic
activation
its
demonstrated
intracellularly.
To
enhance
flexibility
strategy,
clickable
azide
introduced
into
scaffold
allow
integration
more
functionality.
Modularly
derived
mito‐PN
equipped
mitochondria‐targeting
peroxynitrite‐reactive
trigger,
synthesized
superior
performance
cells.
This
strategy
could
lead
customization
applicable
PDT.
Bioconjugate Chemistry,
Год журнала:
2020,
Номер
31(3), С. 492 - 500
Опубликована: Янв. 29, 2020
Enzymatic
reactions
and
self-assembly
are
two
fundamental
attributes
of
cells.
It
is
not
surprising
that
one
can
use
enzyme-instructed
(EISA)-the
integration
enzymatic
transformation
molecular
self-assembly-to
modulate
the
emergent
properties
supramolecular
assemblies
for
controlling
cell
behaviors.
The
exploration
EISA
developing
cancer
therapy
imaging
has
made
considerable
progress
over
last
five
years.
In
this
Topical
Review,
we
discuss
these
exciting
results
future
promise
EISA.
After
describing
several
key
studies
to
illustrate
in
therapy,
imaging.
Then,
give
outlook
anticancer
medicine
inhibits
multiple
hallmark
capabilities
cancer.
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
60(52), С. 26994 - 27004
Опубликована: Окт. 14, 2021
Abstract
Lysosome‐relevant
cell
death
induced
by
lysosomal
membrane
permeabilization
(LMP)
has
recently
attracted
increasing
attention.
However,
nearly
no
studies
show
that
currently
available
LMP
inducers
can
evoke
immunogenic
(ICD)
or
convert
immunologically
cold
tumors
to
hot.
Herein,
we
report
a
inducer
named
TPE‐Py‐pYK(TPP)pY,
which
respond
alkaline
phosphatase
(ALP),
leading
formation
of
nanoassembies
along
with
fluorescence
and
singlet
oxygen
turn‐on.
TPE‐Py‐pYK(TPP)pY
tends
accumulate
in
ALP‐overexpressed
cancer
lysosomes
as
well
induce
rupture
membranes
massively
ICD.
Such
LMP‐induced
ICD
effectively
converts
hot
evidenced
abundant
CD8
+
CD4
T
cells
infiltration
into
the
tumors.
Exposure
ALP‐catalyzed
nanoassemblies
light
further
intensifies
processes
LMP,
cold‐to‐hot
tumor
conversion.
This
work
thus
builds
new
bridge
between
lysosome‐relevant
immunotherapy.
Chemical Reviews,
Год журнала:
2021,
Номер
121(22), С. 14281 - 14347
Опубликована: Май 4, 2021
Self-assembly
is
promising
for
construction
of
a
wide
variety
supramolecular
assemblies,
whose
1D/2D/3D
structures
are
typically
relevant
to
their
functions.
In-depth
understanding
structure–function
relationships
essential
rational
design
and
development
functional
molecular
assemblies.
Microscopic
imaging
has
been
used
as
powerful
tool
elucidate
individual
assemblies
with
subnanometer
millimeter
resolution,
which
complementary
conventional
spectroscopic
techniques
that
provide
the
ensemble
structural
information.
In
this
review,
we
highlight
representative
examples
visualization
by
use
electron
microscopy,
atomic
force
confocal
super-resolution
microscopy.
This
review
comprehensively
describes
nanofibers/gels,
micelles/vesicles,
coacervate
droplets,
polymer
protein/DNA
Advanced
can
address
key
challenges,
like
evaluation
dynamics
multicomponent
self-assembly,
self-assembly/disassembly
in
complex
cellular
milieu,
also
discussed.
We
believe
would
guidelines
deeper
analyses
develop
next-generation
materials.
