Medical micro- and nanomotors in the body

Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 13(2), С. 517 - 541

Опубликована: Окт. 13, 2022

Attributed to the miniaturized body size and active mobility, micro- nanomotors (MNMs) have demonstrated tremendous potential for medical applications. However, from bench bedside, massive efforts are needed address critical issues, such as cost-effective fabrication, on-demand integration of multiple functions, biocompatibility, biodegradability, controlled propulsion in vivo navigation. Herein, we summarize advances biomedical MNMs reported past two decades, with particular emphasis on design, propulsion, navigation, abilities biological barriers penetration, biosensing, diagnosis, minimally invasive surgery targeted cargo delivery. Future perspectives challenges discussed well. This review can lay foundation future direction MNMs, pushing one step forward road achieving practical theranostics using MNMs.

Язык: Английский

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Advanced tools and methods for single-cell surgery

Microsystems & Nanoengineering, Год журнала: 2022, Номер 8(1)

Опубликована: Апрель 29, 2022

Abstract Highly precise micromanipulation tools that can manipulate and interrogate cell organelles components must be developed to support the rapid development of new cell-based medical therapies, thereby facilitating in-depth understanding dynamics, component functions, disease mechanisms. This paper presents a literature review on micro/nanomanipulation their control methods for single-cell surgery. Micromanipulation specifically based laser, microneedle, untethered micro/nanotools are presented in detail. The limitations these techniques also discussed. biological significance clinical applications surgery addressed this paper.

Язык: Английский

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Carbon Helical Nanorobots Capable of Cell Membrane Penetration for Single Cell Targeted SERS Bio‐Sensing and Photothermal Cancer Therapy

Advanced Functional Materials, Год журнала: 2022, Номер 32(30)

Опубликована: Май 8, 2022

Abstract Penetration of cell membrane at micro/nano‐scale with untethered probe is great scientific significance, yet still challenging. Here, a carbon nanocoil based magnetic nanorobot, which can precisely target single and perform penetration, reported. The nanorobots are as‐synthesized by chemical vapor deposition high yield, followed physical Ni Au nanofilms. Rotating electromagnetic fields used to steer the navigate following any pre‐designed path. helical realize mechanical perforation plasma even nuclear envelope precise position subcellular level. With aid externally deposited nanofilm, surface enhanced Raman scattering bio‐sensing signals be collected from cellular nucleus. Furthermore, demonstrate capability efficient photothermal therapy against targeted cancer cells serve as an integrated theranostic platform, providing promising prospects in future precision medicine.

Язык: Английский

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Untethered Small-Scale Machines for Microrobotic Manipulation: From Individual and Multiple to Collective Machines

ACS Nano, Год журнала: 2023, Номер 17(14), С. 13081 - 13109

Опубликована: Июль 13, 2023

Untethered small-scale machines (USSMs) that can actively adjust their motion, deformation, and collective states in response to external stimuli have gained enormous interest various manipulation, sensing, biomedical applications. Because they be efficiently operated confined tortuous environments, USSMs are capable of conducting wireless microrobotic manipulation tasks tethered find hard achieve. Over the past decade development, significant research progress has been achieved designing USSM-based strategies, which enabled by investigating machine-object, machine-environment, machine-machine interactions. This review summarizes latest developments for utilizing individual machines, coordinating multiple inducing behaviors. Providing recent studies relevant applications areas, we also discuss challenges future perspectives facing USSMs-based intelligent systems achieve complex environments with imaging-guided processes increasing autonomy levels.

Язык: Английский

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Bioinspired Jellyfish-like Carbon/Manganese nanomotors with H2O2 and NIR light Dual-propulsion for enhanced tumor penetration and chemodynamic therapy

Chemical Engineering Journal, Год журнала: 2023, Номер 461, С. 142142 - 142142

Опубликована: Фев. 26, 2023

Язык: Английский

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