Chemistry - A European Journal,
Год журнала:
2020,
Номер
26(67), С. 15378 - 15396
Опубликована: Авг. 12, 2020
Abstract
Remote
functionalization
reactions
have
the
power
to
transform
a
C−H
(or
C−C)
bond
at
distant
position
from
functional
group.
This
Review
summarizes
recent
advances
and
key
breakthroughs
in
remote
fluorination,
trifluoromethylation,
difluoromethylation,
trifluoromethylthiolation,
fluoroalkenylation
reactions.
Several
powerful
strategies
emerged
control
reactivity
distal
selectivity
such
as
undirected
radical
approach,
1,5‐hydrogen
atom
transfer,
metal
migration,
use
of
directing
groups,
ring‐opening
These
unconventional
predictable
(and
transformations
should
allow
for
preparation
wide
range
otherwise‐difficult‐to‐access
alkyl,
aromatic,
heteroaromatic,
structurally
complex
fluorides.
Chemical Science,
Год журнала:
2022,
Номер
13(18), С. 5382 - 5389
Опубликована: Янв. 1, 2022
Construction
of
C(sp2)-C(sp3)
bonds
via
regioselective
coupling
C(sp2)-H/C(sp3)-H
is
challenging
due
to
the
low
reactivity
and
regioselectivity
C-H
bonds.
Here,
a
novel
photoinduced
Ru/photocatalyst-cocatalyzed
cross-dehydrogenative
dual
remote
bonds,
including
inert
γ-C(sp3)-H
in
amides
meta-C(sp2)-H
arenes,
construct
meta-alkylated
arenes
has
been
accomplished.
This
metallaphotoredox-enabled
site-selective
between
C(sp3)-H
characterized
by
its
unique
site-selectivity,
redox-neutral
conditions,
broad
substrate
scope
wide
use
late-stage
functionalization
bioactive
molecules.
Moreover,
this
reaction
represents
case
unactivated
alkanes
new
catalytic
process
provides
strategy
for
meta-functionalized
under
mild
conditions.
Density
functional
theory
(DFT)
calculations
control
experiments
explained
site-selectivity
detailed
mechanism
reaction.
Organic Chemistry Frontiers,
Год журнала:
2022,
Номер
9(8), С. 2220 - 2227
Опубликована: Янв. 1, 2022
Catalyst-free
visible-light
irradiation
has
leveraged
the
big
redox
potential
gaps
between
arylsulfonium
salts
and
[Me
4
N][SeCF
3
],
which
combined
with
sulfenylation
processes
offers
convenient
selective
C–H
trifluoromethylselenolation.
Organic Letters,
Год журнала:
2020,
Номер
22(7), С. 2828 - 2832
Опубликована: Март 24, 2020
Here
we
report
a
method
for
the
site-selective
intermolecular
C(sp3)-H
amination
of
carboxamides
by
merging
transition-metal
catalysis
and
hydrogen
atom
transfer
strategy.
The
reaction
proceeds
through
sequence
favorable
single-electron
transfer,
1,5-hydrogen
C-N
cross-coupling
steps,
thus
allowing
access
to
series
desired
products.
This
could
accommodate
wide
diversity
nitrogen
nucleophiles
as
well
demonstrate
excellent
chemoselectivity
functional
group
compatibility.
Chemistry - A European Journal,
Год журнала:
2020,
Номер
26(67), С. 15378 - 15396
Опубликована: Авг. 12, 2020
Abstract
Remote
functionalization
reactions
have
the
power
to
transform
a
C−H
(or
C−C)
bond
at
distant
position
from
functional
group.
This
Review
summarizes
recent
advances
and
key
breakthroughs
in
remote
fluorination,
trifluoromethylation,
difluoromethylation,
trifluoromethylthiolation,
fluoroalkenylation
reactions.
Several
powerful
strategies
emerged
control
reactivity
distal
selectivity
such
as
undirected
radical
approach,
1,5‐hydrogen
atom
transfer,
metal
migration,
use
of
directing
groups,
ring‐opening
These
unconventional
predictable
(and
transformations
should
allow
for
preparation
wide
range
otherwise‐difficult‐to‐access
alkyl,
aromatic,
heteroaromatic,
structurally
complex
fluorides.
