Recent Progress in Cancer Vaccines and Nanovaccines

Biomaterials, Год журнала: 2024, Номер 314, С. 122856 - 122856

Опубликована: Сен. 28, 2024

Язык: Английский

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Self-Assembling protein nanoparticle platform for multivalent antigen delivery in vaccine development

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125597 - 125597

Опубликована: Апрель 1, 2025

Язык: Английский

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Exaggerated Lung Inflammation Induced by Lung-Targeted mRNA-LNP Dampens Vaccines against Tuberculosis

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

The challenges in developing a tuberculosis (TB) vaccine stem from the complex life cycle of Mycobacterium (Mtb) and various bacterial proteins encoded by approximately 4000 genes. mRNA is easy to design can accommodate multiple antigens, suggesting that it may be an effective TB technology. Here, we designed encoding Ag85B ESAT6 was delivered lung targeted lipid nanoparticles (LNPlung-mRNAA-E), intending stimulate immunity combat TB. To enhance efficacy, further cofabricated monophosphoryl A (MPLA) with evaluate adjuvanted (LNPlung-mRNAA-E-MPLA). Both vaccines elicited robust CD4+ T cell response, resulting markedly locally higher production IFN-γ, TNF-α, IL-2. As anticipated, addition MPLA enhanced immunogenicity LNPlung-mRNAA-E. However, Mtb challenge experiment showed LNPlung-mRNAA-E-MPLA neither provided protection nor immune primed BCG (Bacillus Calmette-Guérin). subsequent HE staining revealed induced pulmonary inflammation, leading tissue damage. Moreover, inflammatory cytokines including IL-6, IL-1β, MCP-1 were significantly increased additive exacerbated process. Therefore, adjuvant synergistically inflammation weakened infection. Thus, this work provides valuable implications for vaccines: Addressing chronic systems critical lung-targeted vaccines.

Язык: Английский

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Polyethyleneimine-modified Laminarin nanoparticles as a novel vaccine adjuvant for ovalbumin to enhance the immune responses

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139157 - 139157

Опубликована: Дек. 1, 2024

Язык: Английский

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