Serum concentrations of per- and poly-fluoroalkyl substances (PFAS) in Danish pregnant women—temporal trends during pregnancy, correlations with partners, associations with physical activity, and blood lipid concentrations DOI Creative Commons
Ida Karoline Bach Jensen, Esben Budtz‐Jørgensen, Christian Lindh

и другие.

Environmental Health, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 2, 2025

Per- and polyflouralkyl substances (PFAS) are a group of persistent chemicals used extensively in industries consumer products due to their water-repellent properties. Studies have linked PFAS exposure adverse health effects, human PFAS, especially during pregnancy, is great concern. In this study, we report how serum concentrations pregnancy correlated with partners from the same household. Further, change course associations between blood lipid as well exploratory analyses physical activity concentrations. secondary analysis data FitMum study conducted 2018 2021, 216 healthy, pregnant women, 110 were included. Non-fasting venous samples collected mothers at three test visits delivery, where also collected. Serum all timepoints analyzed for 15 short- long-chained using liquid chromatography triple quadrupole linear ion trap mass spectrometry. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C) triglyceride measured delivery. Physical was wrist-worn tracker 24/7 inclusion before gestational age week + 0 throughout pregnancy. detected following PFAS: PFOS, PFOA, PFHxS, PFNA, PFDA, PFUnDA. The maternal median baseline were: PFOS: 4.09 ng/mL, PFOA: 0.81 PFHxS: 0.29 PFNA: 0.42 PFDA: 0.25 PFUnDA: 0.19 ng/mL. Partner 3-145% higher than concentration (except PFUnDA). within couples. All decreased significantly (PFOS -23.1 percent 95%-CI [-31.9;-13.2] delivery). associated increased HDL-C No found. Overall, households strongly correlated. positively associated. We found no registered ClinicalTrials.gov; NCT03679130; 20/09/2018.

Язык: Английский

Serum concentrations of per- and poly-fluoroalkyl substances (PFAS) in Danish pregnant women—temporal trends during pregnancy, correlations with partners, associations with physical activity, and blood lipid concentrations DOI Creative Commons
Ida Karoline Bach Jensen, Esben Budtz‐Jørgensen, Christian Lindh

и другие.

Environmental Health, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 2, 2025

Per- and polyflouralkyl substances (PFAS) are a group of persistent chemicals used extensively in industries consumer products due to their water-repellent properties. Studies have linked PFAS exposure adverse health effects, human PFAS, especially during pregnancy, is great concern. In this study, we report how serum concentrations pregnancy correlated with partners from the same household. Further, change course associations between blood lipid as well exploratory analyses physical activity concentrations. secondary analysis data FitMum study conducted 2018 2021, 216 healthy, pregnant women, 110 were included. Non-fasting venous samples collected mothers at three test visits delivery, where also collected. Serum all timepoints analyzed for 15 short- long-chained using liquid chromatography triple quadrupole linear ion trap mass spectrometry. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C) triglyceride measured delivery. Physical was wrist-worn tracker 24/7 inclusion before gestational age week + 0 throughout pregnancy. detected following PFAS: PFOS, PFOA, PFHxS, PFNA, PFDA, PFUnDA. The maternal median baseline were: PFOS: 4.09 ng/mL, PFOA: 0.81 PFHxS: 0.29 PFNA: 0.42 PFDA: 0.25 PFUnDA: 0.19 ng/mL. Partner 3-145% higher than concentration (except PFUnDA). within couples. All decreased significantly (PFOS -23.1 percent 95%-CI [-31.9;-13.2] delivery). associated increased HDL-C No found. Overall, households strongly correlated. positively associated. We found no registered ClinicalTrials.gov; NCT03679130; 20/09/2018.

Язык: Английский

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