Role of the Synergistic Interactions of Environmental Pollutants in the Development of Cancer

GeoHealth, Год журнала: 2022, Номер 6(4)

Опубликована: Апрель 1, 2022

Abstract There is a growing awareness that the large number of environmental pollutants we are exposed to on daily basis causing major health problems. Compared traditional studies focus individual pollutants, there relatively few how mixtures interact. Several have reported relationship between and development cancer, even when pollutant levels below toxicity reference values. The possibility synergistic interactions different could explain low concentrations can cause These intricate molecular occur through wide variety mechanisms, our understanding physiological effects still limited. purpose this paper discuss recent reports address possible types promote cancer development. Our literature suggest key biological pathways frequently implicated in such processes. include increased production reactive oxygen species, activation by cytochrome P450, aryl hydrocarbon receptor signaling, among others. We need understand pathological vulnerability not only relation basic genetics gene expression, but also terms measurable exposure contaminants. mention for significant improvements future using multitude disciplines, as high‐throughput study models, better tools quantifying patients, innovative pharmacological toxicological studies, high‐efficiency computer analysis, which allow us analyze mechanisms mixtures.

Язык: Английский

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Predictive in silico models for aquatic toxicity of cosmetic and personal care additive mixtures

Water Research, Год журнала: 2023, Номер 236, С. 119981 - 119981

Опубликована: Апрель 14, 2023

Язык: Английский

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Association of Combined Per- and Polyfluoroalkyl Substances and Metals with Chronic Kidney Disease

International Journal of Environmental Research and Public Health, Год журнала: 2024, Номер 21(4), С. 468 - 468

Опубликована: Апрель 11, 2024

Background: Exposure to environmental pollutants such as metals and Per- Polyfluoroalkyl Substances (PFAS) has become common increasingly associated with a decrease in the estimated Glomerular Filtration Rate (eGFR), which is marker often used measure chronic kidney disease (CKD). However, there are limited studies involving use of both eGFR urine albumin creatinine ratio (uACR), more comprehensive markers determine presence CKD complexity pollutant exposures response interactions, especially for combined PFAS, not been comprehensively elucidated. Objective: This study aims assess individual effects perfluorooctanoic acid (PFOA), perfluorooctanesulfonic (PFOS), Cadmium (Cd), Mercury (Hg), Lead (Pb) exposure on using data from National Health Nutritional Examination Survey (NHANES) 2017–2018. Methods: We employed bivariate logistic regression Bayesian Kernel Machine Regression (BKMR) our analysis data. Results: Logistic results revealed positive association between PFOA CKD. Our BKMR non-linear bi-phasic relationship metal In univariate exposure–response function plot, Cd Hg exhibited U N-shaped interaction, indicated non-additive low high addition, two mixture that had U-shaped at different quantiles Pb, Hg, PFOA, PFOS, indicating levels CKD, implying complex biological interaction. Hg’s interaction plot demonstrated across all Cd, 75th quantile Pb 50th PFOS. Furthermore, PIP underscored Cd’s consistent (PIP = 1.000) followed by 0.9984), then PFOS closely related 0.7880 0.7604, respectively, finally 0.6940), contributing least among five though significant. Conclusions: findings pollutants, particularly These highlight need public health interventions strategies mitigate cumulative effect PFAS elucidate significance utilizing advanced statistical methods tools understand impact human health. Further research needed mechanistic pathways metal-induced injury longitudinal required ascertain long-term these exposures.

Язык: Английский

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Health Risks of Asphalt Emission: State-of-the-Art Advances and Research Gaps

Journal of Hazardous Materials, Год журнала: 2024, Номер unknown, С. 136048 - 136048

Опубликована: Окт. 1, 2024

Язык: Английский

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Mendelian randomization analysis of environmental pollution factors and head and neck cancer risk: a causal inference study integrating autophagy-related genes

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Март 11, 2025

Head and neck squamous cell carcinoma (HNSC) is a significant global health challenge. While traditional risk factors are well-established, the role of environmental pollutants in HNSC development remains unclear. To investigate causal relationship between pollution using Mendelian Randomization (MR) analysis. Two-sample MR analysis was performed genome-wide association study data from IEU OpenGWAS project RNA-seq TCGA. Environmental pollution-associated genes (MRGs) were identified analyzed along with autophagy-related (ATGs) samples. Cox proportional hazards models used to develop clinical prediction model. revealed relationships nitrogen dioxide air pollution, oxides PM2.5, increased risk. Nine MRGs identified, four (IRF4, LINGO1, PTHLH, RSRC1) differentially expressed HNSC. A six-factor model RSRC1, Age, USP10) showed good predictive performance for survival (C-index = 0.63, 10-year AUC 0.761). Tumor mutation burden immune infiltration analyses provided further insights into biology. This provides evidence specific risk, identifies potential gene targets investigation. The developed may aid prognosis personalized treatment strategies.

Язык: Английский

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Hepatic damage in residents of a major coal mining region in Brazil

Deleted Journal, Год журнала: 2025, Номер 22(1)

Опубликована: Март 19, 2025

Coal mining and the subsequent burning of coal release waste products that can accumulate in environment pose a threat to human health. Therefore, this study aims evaluate hepatic damage by bilirubin, ALP, ALT, GGT among men from largest region Brazil. A cross-sectional was conducted seven municipalities Brazil's region. Participants were male individuals (n = 320) residing these municipalities, with varying degrees exposure activities. Socioeconomic, demographic, lifestyle, health information collected, along blood samples for measuring liver function markers: alkaline phosphatase, alanine aminotransferase, gamma-glutamyltransferase. Despite population's average markers falling within reference range, approximately half participants exhibited signs altered function. The municipality at center activities showed highest levels (except gamma-glutamyltransferase), nearly its residents exhibiting evidence damage. Socioeconomic status mate consumption found be significantly inversely correlated Additionally, who smoked had higher risk developing problems. These findings underscore need comprehensive strategies address impacts environmental pollutants associated mining. Preventive measures regulatory policies are crucial protect public regions affected industry.

Язык: Английский

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The Gut Microbiome and Its Multifaceted Role in Cancer Metabolism, Initiation, and Progression: Insights and Therapeutic Implications

Technology in Cancer Research & Treatment, Год журнала: 2025, Номер 24

Опубликована: Апрель 1, 2025

This review summarizes the intricate relationship between microbiome and cancer initiation development. Microbiome alterations impact metabolic pathways, immune responses, gene expression, which can accelerate or mitigate progression. We examine how dysbiosis affects tumor growth, metastasis, treatment resistance. Additionally, we discuss potential of microbiome-targeted therapies, such as probiotics fecal microbiota transplants, to modulate metabolism. These interventions offer possibility reversing controlling progression, enhancing efficacy traditional treatments like chemotherapy immunotherapy. Despite promising developments, challenges remain in identifying key microbial species pathways validating therapies through large-scale clinical trials. Nonetheless, intersection research development presents an exciting frontier for innovative therapies. offers a fresh perspective on by integrating insights, highlighting interdisciplinary enhance our understanding progression strategies.

Язык: Английский

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Linking Benzene, in Utero Carcinogenicity and Fetal Hematopoietic Stem Cell Niches: A Mechanistic Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6335 - 6335

Опубликована: Март 28, 2023

Previous research reported that prolonged benzene exposure during in utero fetal development causes greater abnormalities than adult-stage exposure. This phenomenon increases the risk for disease at stage, particularly carcinogenesis, which is mainly associated with hematological malignancies. Benzene has been to potentially act via multiple modes of action target hematopoietic stem cell (HSCs) niche, a complex microenvironment HSCs and multilineage progenitor cells (HSPCs) reside. Oxidative stress, chromosomal aberration epigenetic modification are among known mechanisms mediating benzene-induced genetic leading carcinogenesis. Hence, it crucial monitor carcinogenic environmental, occupational or lifestyle factors pregnant women. well-known cause adult leukemia. However, proof involvement childhood leukemia remains scarce despite previously linking incidences disorders maternal Furthermore, accumulating evidence shown able alter developmental functional properties HSPCs, fetus children. Since HSPCs parental blood regulate hematopoiesis stages, targets may induce damage population trigger diseases. Therefore, mechanism carcinogenicity by targeting primary focus this review.

Язык: Английский

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DNA damage accumulation and repair defects in FLT3‐ITD acute myeloid leukemia: Implications for clonal evolution and disease progression

Hematological Oncology, Год журнала: 2022, Номер 41(1), С. 26 - 38

Опубликована: Сен. 22, 2022

Abstract Acute myeloid leukemia is a group of hematological diseases that have high mortality rate. During the development this pathology, hematopoietic cells acquire chromosomal rearrangements and multiple genetic mutations, including FLT3‐ITD. FLT3‐ITD marker associated with poor clinical prognosis involves activation pathways such as PI3K/AKT, MAPK/ERK, JAK/STAT favor survival proliferation leukemic cells. In addition, leads to overproduction reactive oxygen species defective DNA damage repair, both implicated in appearance new mutations clones. Thus, purpose review illustrate molecular mechanisms through which generates instability how it facilitates clonal evolution generation more resistant aggressive Likewise, article discusses feasibility combined therapies FLT3 inhibitors repair pathways.

Язык: Английский

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Polyphenols as Suitable Control for Obesity and Diabetes

The Open Biotechnology Journal, Год журнала: 2018, Номер 12(1), С. 219 - 228

Опубликована: Сен. 28, 2018

Modern life is characterized by physical inactivity and poor food choices, which often a prerequisite for unhealthy weight gain overweight/obesity. These factors unlock the emergence of number diseases including diabetes, cardiovascular problems, different types cancer, etc. The pursuit scientists to seek strategies prevent, relieve cure patient leads usage natural compounds potential beneficial effect. Polyphenols are large group naturally occurring secondary metabolites mainly found in plants beverages. presence these seems decrease manifestation miscellaneous disease-causing symptoms. purpose this review synthesize information about polyphenols their controlling obesity diabetes. considered as health-beneficial sources thus could be involved novel preventing diabetes complications.

Язык: Английский

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