Associations between alcohol consumption and gray and white matter volumes in the UK Biobank

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Март 4, 2022

Abstract Heavy alcohol consumption has been associated with brain atrophy, neuronal loss, and poorer white matter fiber integrity. However, there is conflicting evidence on whether light-to-moderate shows similar negative associations structure. To address this, we examine the between intake structure using multimodal imaging data from 36,678 generally healthy middle-aged older adults UK Biobank, controlling for numerous potential confounds. Consistent prior literature, find macrostructure microstructure. Specifically, negatively global volume measures, regional gray volumes, Here, show that microstructure are already apparent in individuals consuming an average of only one to two daily units, become stronger as increases.

Язык: Английский

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Hazardous drinking and alcohol use disorders

Nature Reviews Disease Primers, Год журнала: 2022, Номер 8(1)

Опубликована: Дек. 22, 2022

Язык: Английский

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Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

Antioxidants, Год журнала: 2022, Номер 11(7), С. 1374 - 1374

Опубликована: Июль 15, 2022

Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The underlying mechanism of ethanol neurotoxicity the involvement oxidative stress still not fully elucidated. However, metabolism has been associated with increased through alcohol dehydrogenase, microsomal oxidation system, catalase metabolic pathways. We searched PubMed genome-wide association studies (GWAS) catalog databases to review literature systematically summarized findings focusing on AUD abstinence in relation stress. In addition, we reviewed ClinicalTrials.gov resource US National Library Medicine identify all ongoing completed clinical trials that include therapeutic interventions based antioxidants. retrieved preclinical show impacts genetics, metabolism, inflammation, neurodegeneration.

Язык: Английский

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Blood-based epigenome-wide association study and prediction of alcohol consumption

Clinical Epigenetics, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 25, 2025

Abstract Alcohol consumption is an important risk factor for multiple diseases. It typically assessed via self-report, which open to measurement error through recall bias. Instead, molecular data such as blood-based DNA methylation (DNAm) could be used derive a more objective measure of alcohol by incorporating information from cytosine-phosphate-guanine (CpG) sites known linked the trait. Here, we explore epigenetic architecture self-reported weekly units in Generation Scotland study. We first create score (EpiScore) using elastic net penalized linear regression. effect pre-filtering CpG features ahead net, well differential patterns sex and consumed last week relative average week. The final EpiScore was trained on 16,717 individuals tested four external cohorts: Lothian Birth Cohorts (LBC) 1921 1936, Sister Study, Avon Longitudinal Study Parents Children (total N across studies > 10,000). maximum Pearson correlation between within cohort ranged 0.41 0.53. In LBC1936, higher levels had significant associations with poorer global brain imaging metrics, whereas did not. Finally, identified two novel loci Bayesian regression epigenome-wide association study consumption. Together, these findings show how DNAm can objectively characterize that associate health, unlike estimates.

Язык: Английский

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Structural brain changes associated with risky drinking in late-life depression

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Factors influencing aging in high-income countries

Oxford University Press eBooks, Год журнала: 2025, Номер unknown, С. 23 - 34

Опубликована: Фев. 1, 2025

Abstract Aging is a critical issue for families, policymakers, healthcare providers, and society at large. This chapter explores the biological, environmental, behavioural, psychosocial factors that influence experience of aging in high-income countries. Age-related decline, emergence chronic disease, social isolation, functional changes occur context urbanization, population shifts, limitations workforce among other factors. Responses to include programmes support informal carers, implementation integrated models healthcare, mitigation impact health well-being. In parallel ideas age-related concepts positive emphasize independence minimize disability also countries, although these benefits security are unequally experienced due differential exposure environments promote well-being or illness. Therapies disease policies bolster poorly resourced decrease harmful exposures need be implemented within framework equity.

Язык: Английский

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Alcohol and aging: Next‐generation epigenetic clocks predict biological age acceleration in individuals with alcohol use disorder

Alcohol Clinical and Experimental Research, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Abstract Background Chronic heavy alcohol use is a major risk factor for premature aging and age‐related diseases. DNA methylation (DNAm)‐based epigenetic clocks are novel tools predicting biological age. However, the newest configurations, causality‐enriched clocks, have not been assessed in context of consumption disorder (AUD). Methods Epigenetic was evaluated sample 615 individuals (372 AUD patients 243 healthy controls) by applying GrimAge Version 1 (V1) 2 (V2) alongside three (CausAge, DamAge, AdaptAge). A linear model controlling diagnosis, sex, race, BMI, smoking status, five blood cell types leveraged to test associations between alcohol‐related metrics age‐adjusted clocks. Results V1 V2 maintained significant with drinking behavior measures within total both young (<40 years old) old (≥40 subgroups. Generally, slightly outperformed V1, while none demonstrated AUD. subgroup, DamAge had association number drinks. Across age subgroups, liver function enzymes, consistently sustained stronger compared V1. Among fourth‐generation exhibited gamma‐glutamyl transferase (GGT) aspartate aminotransferase subgroup; CausAge displayed GGT sample. Examining clinical biomarkers, showed improved C‐reactive protein Conclusions Overall, we observed moderately performance majority parameters tested. The lacked but demonstrate complexities inspire further research dynamics.

Язык: Английский

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Reactive Oxygen Species as a Common Pathological Link Between Alcohol Use Disorder and Alzheimer’s Disease with Therapeutic Implications

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3272 - 3272

Опубликована: Апрель 1, 2025

Chronic alcohol consumption leads to excessive production of reactive oxygen species (ROS), driving oxidative stress that contributes both use disorder (AUD) and Alzheimer's disease (AD). This review explores how ROS-mediated mitochondrial dysfunction neuroinflammation serve as shared pathological mechanisms linking these conditions. We highlight the role alcohol-induced damage in exacerbating neurodegeneration compare ROS-related pathways AUD AD. Finally, we discuss emerging therapeutic strategies, including antioxidants inflammasome inhibitors, target mitigate neurodegeneration. Understanding overlapping may provide new insights for preventing treating ROS-driven neurodegenerative disorders.

Язык: Английский

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Accelerated Aging of the Amygdala in Alcohol Use Disorders: Relevance to the Dark Side of Addiction

Cerebral Cortex, Год журнала: 2021, Номер 31(7), С. 3254 - 3265

Опубликована: Янв. 19, 2021

Abstract Here we assessed changes in subcortical volumes alcohol use disorder (AUD). A simple morphometry-based classifier (MC) was developed to identify that distinguished 32 healthy controls (HCs) from 33 AUD patients, who were scanned twice, during early and later withdrawal, assess the effect of abstinence on MC-features (Discovery cohort). We validated novel an independent Validation cohort (19 patients 20 HCs). MC-accuracy reached 80% (Discovery) 72% (Validation). MC features included hippocampus, amygdala, cerebellum, putamen, corpus callosum, brain stem, which smaller showed stronger age-related decreases than HCs, ventricles cerebrospinal fluid, larger older participants. The volume amygdala a positive association with anxiety negative urgency AUD. Repeated imaging third week detoxification revealed slightly consistent partial recovery abstinence. steeper age-associated volumetric reductions stress- reward-related regions are accelerated aging, whereas amygdalar associations support its involvement “dark side addiction”.

Язык: Английский

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The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(8), С. 4387 - 4387

Опубликована: Апрель 15, 2022

During the aging process our body becomes less well equipped to deal with cellular stress, resulting in an increase unrepaired damage. This causes varying degrees of impaired functionality and increased risk mortality. One most effective anti-aging strategies involves interventions that combine simultaneous glucometabolic support augmented DNA damage protection/repair. Thus, it seems prudent develop therapeutic target this combinatorial approach. Studies have shown ADP-ribosylation factor (ARF) GTPase activating protein GIT2 (GIT2) acts as a keystone process. can control both repair glucose metabolism. Through vivo co-regulation analyses was found forms close coexpression-based relationship relaxin-3 receptor (RXFP3). Cellular RXFP3 expression is directly affected by oxidative stress. Overexpression or stimulation receptor, its endogenous ligand relaxin 3 (RLN3), regulate response processes. Interestingly, RLN3 insulin-like peptide has been multiple disease processes linked mechanisms, e.g., anxiety, depression, memory dysfunction, appetite, anti-apoptotic mechanisms. Here we discuss molecular mechanisms underlying various roles RXFP3/RLN3 signaling age-related disorders.

Язык: Английский

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