Psychosocial Correlates of Insomnia Symptoms Among Women and Men Receiving Buprenorphine Treatment for Opioid Use Disorder

NeuroSci, Год журнала: 2025, Номер 6(2), С. 48 - 48

Опубликована: Май 30, 2025

Insomnia is common in individuals with opioid use disorder (OUD). Biopsychosocial factors are important sleep health, yet this intersection has to be fully elucidated people on buprenorphine for OUD. The objective report patient-reported biopsychosocial among and without insomnia, specifically women men outpatient OUD treatment. parent study enrolled adults stabilized from February 2022–September 2023. Scores of ≥11 the Severity Index (ISI) indicated clinically significant insomnia. Differences were detected by presence stratified women, using chi-squared Fisher’s exact tests. Of overall participants (N = 130), most (n 77; 59.2%) met criteria Women insomnia more likely social stressors including discrimination substance (p 0.040), food insecurity 0.032), transportation difficulties accessing healthcare 0.043) than Men financial 0.023) These findings provide a unique perspective consider development implementation interventions receiving medication treatment

Язык: Английский

---

Objective sleep outcomes in randomized-controlled trials in persons with substance use disorders: A systematic review

Drug and Alcohol Dependence, Год журнала: 2022, Номер 237, С. 109509 - 109509

Опубликована: Май 25, 2022

Язык: Английский

---

Patient-reported sleep outcomes in randomized-controlled trials in persons with substance use disorders: A systematic review

Drug and Alcohol Dependence, Год журнала: 2022, Номер 237, С. 109508 - 109508

Опубликована: Май 25, 2022

Язык: Английский

---

Post-traumatic stress disorder symptomatology is associated with insomnia among women engaged in opioid use disorder treatment with buprenorphine

Archives of Women s Mental Health, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Abstract This study aimed to explore the association between degree of PTSD symptomatology and severity insomnia symptoms in a clinical sample women receiving buprenorphine for OUD. was assessed via PCL-5, were determined Insomnia Severity Index. Analyses indicated that more participants experiencing clinically significant also reported than their counterparts. Future work should investigate how holistic care (e.g., trauma-informed approaches) addresses overlap trauma sleep disturbance could inform gender-specific OUD treatment strategies overdose crisis.

Язык: Английский

---

Objective and subjective measurement of sleep in people who use substances: Emerging evidence and recommendations from a systematic review

Journal of Sleep Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 5, 2024

Summary People who use substances commonly experience sleep disruptions, affecting the regulation of physical and mental health, presenting a significant barrier to treatment success. Sleep impairments are noted in all phases substance use; however, differences between subjective versus objective methods used measure quality have been reported. While polysomnography is gold‐standard for measurement, recent advances actigraphy may help address discordance reports. This systematic review examined emerging evidence (2016–present) impairment people substances, with twofold goal of: (1) identifying whether outcomes vary across type (alcohol, nicotine, cannabis, cocaine, methamphetamine opioids); (2) contrasting results from measures. some were noted, there was overwhelming clinically relevant alcohol, opioids, less consistent cannabis. Gaps literature identified future recommendations presented, including utilization common methodological frameworks, identification mechanisms, closer examination stages interconnection return use.

Язык: Английский

---

Endogenous opioid signaling in the retina modulates sleep/wake activity in mice

Neurobiology of Sleep and Circadian Rhythms, Год журнала: 2022, Номер 13, С. 100078 - 100078

Опубликована: Июнь 26, 2022

Circadian sleep/wake rhythms are synchronized to environmental light/dark cycles in a process known as photoentrainment. We have previously shown that activation of β-endorphin-preferring μ-opioid receptors (MORs) inhibits the light-evoked firing intrinsically photosensitive retinal ganglion cells (ipRGCs), sole conduits Although we β-endorphin is expressed adult mouse retina, conditions under which unknown. Moreover, it unclear whether endogenous MORs by ipRGCs modulates photoentrainment cycles. To elucidate this, first measured mRNA expression β-endorphin's precursor, proopiomelanocortin (POMC), at various times day quantitative reverse-transcription PCR. POMC appears cyclic retina. then studied with immunohistochemistry and found more highly dark/at night. Finally, used telemetry measure activity, EEG EMG freely moving animals compare wild-type transgenic mice only lack functional MORs. Results from these experiments suggest contribute induction maintenance activity dark phase nocturnal mice, via promotion wakefulness inhibition slow-wave sleep. Together, data activates modulate pathway.

Язык: Английский

---

Sex‐specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia

Genes Brain & Behavior, Год журнала: 2022, Номер 21(7)

Опубликована: Авг. 20, 2022

Abstract Opioids like fentanyl remain the mainstay treatment for chronic pain. Unfortunately, opioid's high dependence liability has led to current opioid crisis, in part, because of side‐effects that develop during long‐term use, including analgesic tolerance and physical dependence. Both opioids may lead escalation required doses achieve previous therapeutic efficacy. Additionally, altered sleep circadian rhythms are common people on therapy. impact rhythms, while disruptions likely mediate effects opioids. However, mechanisms underlying these bidirectional relationships between largely unknown. The protein, neuronal PAS domain protein 2 (NPAS2), regulates circadian‐dependent gene transcription structure central nervous system modulate Here, male female wild‐type NPAS2‐deficient (NPAS2−/−) mice were used investigate role NPAS2 analgesia, tolerance, hyperalgesia Overall, thermal pain thresholds, acute analgesia a fixed dose similar NPAS2−/− mice. exhibited augmented significantly more behavioral symptoms fentanyl. Only had increased fentanyl‐induced hypersensitivity, when compared with males. Together, our findings suggest sex‐specific signaling regulation

Язык: Английский

---

The impact of opioid-stimulant co-use on tonic and cue-induced craving

Journal of Psychiatric Research, Год журнала: 2023, Номер 164, С. 15 - 22

Опубликована: Май 17, 2023

Язык: Английский

---

Morphine pharmacokinetics and opioid transporter expression at the blood-retina barrier of male and female mice

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Июнь 14, 2023

Opioids are effective analgesics for treating moderate to severe pain, however, their use must be weighed against dangerous side effects. Investigations into opioid pharmacokinetics provide crucial information regarding both on- and off-target drug Our recent work showed that morphine deposits accumulates in the mouse retina at higher concentrations than brain upon chronic systemic exposure. We also found reduced retinal expression of P-glycoprotein (P-gp), a major extruder blood-brain barrier (BBB). Here, we systematically interrogated three putative transporters blood-retina (BRB): P-gp, breast cancer resistance protein (Bcrp) multidrug 2 (Mrp2). Using immunohistochemistry, robust P-gp Bcrp, but not Mrp2, inner BRB retina. Previous studies have suggested may regulated by sex hormones. However, acute treatment no differences deposition levels or brain, nor on transporter retinas males females with high low estrogen:progesterone ratio. Importantly, significantly correlated concentration retina, suggesting is predominant BRB. In addition, fluorescence extravasation revealed did alter permeability either BBB Together, these data suggest mediates accumulation delivery, turn, potential effects circadian photoentrainment.

Язык: Английский

---

Patient reported preferences for sleep interventions among women receiving buprenorphine for opioid use disorder

Frontiers in Psychiatry, Год журнала: 2023, Номер 14

Опубликована: Сен. 14, 2023

Aim Among individuals receiving medication for OUD (MOUD), insomnia is highly prevalent and increases the risk negative outcomes. However, little known about MOUD patient-reported preferences treatments among women with OUD. This mixed-methods study explored acceptability of patient sleep interventions in treatment. Methods an analysis from ongoing cross-sectional survey interview investigating relationship between recovery. The parent actively enrolling non-pregnant 18–45 years stabilized on buprenorphine outpatient program. Participants complete measures including Insomnia Severity Index (ISI), scores ≥10 identifying clinically significant symptoms. A sub-sample who met this threshold completed semi-structured interviews. Descriptive statistics were generated responses, applied thematic was used data. Results selected qualitative ( n = 11) highlighted prior positive experiences treatments, challenges employing non-pharmacological strategies, both medical behavioral while Women emphasized need flexibility therapy sessions to align social determinants (e.g., caregiving responsibilities) as well medications without sedating effects nor dependency. Conclusions Many have concomitant symptoms, desire availability pharmacologic within treatment setting. Qualitative findings underscore evidence-based that account unique socioenvironmental factors may impact strategy implementation population.

Язык: Английский

---