Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
Perfluorohexane
sulfonic
acid
(PFHxS)
is
extensively
used
in
waterproof
coatings
and
fire-fighting
foams,
several
studies
have
found
it
to
be
a
potential
health
hazard,
but
there
still
unknown
about
its
effects
on
spermatogenesis.
Our
results
showed
that
PFHxS-treated
mice
significant
reproductive
toxicity,
including
decrease
sperm
count
motility,
the
levels
of
sex
hormones
(P
<
0.05).
Concurrently,
structural
abnormalities
are
observed
sperm,
affecting
≈60-75%
those
group.
Additionally,
structure
blood-testis
barrier
(BTB)
damaged
after
PFHxS
treatment,
leading
higher
expression
inflammatory
cytokines
microenvironment
for
Moreover,
proteins
associated
with
mitochondrial
biogenesis,
PTEN-induced
kinase
1
(PINK1)
NADPH
oxidase
4
(NOX4),
dysregulated
testes
treatment.
Based
metabolome
data,
differential
metabolite
3-hydroxybutanoic
identified
group,
which
can
regulate
histone
Kac
levels,
especially
H3K4ac
H3K9ac.
In
summary,
this
study
suggest
mice,
factors
disrupt
function
metabolic
profiles
hinder
progress
gene
transcription
through
Kac,
ultimately
causing
dysfunction.
Cell Death and Differentiation,
Год журнала:
2018,
Номер
25(3), С. 486 - 541
Опубликована: Янв. 23, 2018
Over
the
past
decade,
Nomenclature
Committee
on
Cell
Death
(NCCD)
has
formulated
guidelines
for
definition
and
interpretation
of
cell
death
from
morphological,
biochemical,
functional
perspectives.
Since
field
continues
to
expand
novel
mechanisms
that
orchestrate
multiple
pathways
are
unveiled,
we
propose
an
updated
classification
subroutines
focusing
mechanistic
essential
(as
opposed
correlative
dispensable)
aspects
process.
As
provide
molecularly
oriented
definitions
terms
including
intrinsic
apoptosis,
extrinsic
mitochondrial
permeability
transition
(MPT)-driven
necrosis,
necroptosis,
ferroptosis,
pyroptosis,
parthanatos,
entotic
death,
NETotic
lysosome-dependent
autophagy-dependent
immunogenic
cellular
senescence,
mitotic
catastrophe,
discuss
utility
neologisms
refer
highly
specialized
instances
these
processes.
The
mission
NCCD
is
a
widely
accepted
nomenclature
in
support
continued
development
field.
Autophagy,
Год журнала:
2021,
Номер
17(1), С. 1 - 382
Опубликована: Янв. 2, 2021
In
2008,
we
published
the
first
set
of
guidelines
for
standardizing
research
in
autophagy.
Since
then,
this
topic
has
received
increasing
attention,
and
many
scientists
have
entered
field.
Our
knowledge
base
relevant
new
technologies
also
been
expanding.
Thus,
it
is
important
to
formulate
on
a
regular
basis
updated
monitoring
autophagy
different
organisms.
Despite
numerous
reviews,
there
continues
be
confusion
regarding
acceptable
methods
evaluate
autophagy,
especially
multicellular
eukaryotes.
Here,
present
investigators
select
interpret
examine
related
processes,
reviewers
provide
realistic
reasonable
critiques
reports
that
are
focused
these
processes.
These
not
meant
dogmatic
rules,
because
appropriateness
any
assay
largely
depends
question
being
asked
system
used.
Moreover,
no
individual
perfect
every
situation,
calling
use
multiple
techniques
properly
monitor
each
experimental
setting.
Finally,
several
core
components
machinery
implicated
distinct
autophagic
processes
(canonical
noncanonical
autophagy),
implying
genetic
approaches
block
should
rely
targeting
two
or
more
autophagy-related
genes
ideally
participate
steps
pathway.
Along
similar
lines,
proteins
involved
regulate
other
cellular
pathways
including
apoptosis,
all
them
can
used
as
specific
marker
bona
fide
responses.
critically
discuss
current
assessing
information
they
can,
cannot,
provide.
ultimate
goal
encourage
intellectual
technical
innovation
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 11, 2025
Hypoxic
tumors
present
a
significant
challenge
in
cancer
therapy
due
to
their
ability
adaptation
low-oxygen
environments,
which
supports
tumor
survival
and
resistance
treatment.
Enhanced
mitophagy,
the
selective
degradation
of
mitochondria
by
autophagy,
is
crucial
mechanism
that
helps
sustain
cellular
homeostasis
hypoxic
tumors.
In
this
study,
we
develop
an
azocalix[4]arene-modified
supramolecular
albumin
nanoparticle,
co-delivers
hydroxychloroquine
mitochondria-targeting
photosensitizer,
designed
induce
cascaded
oxidative
stress
regulating
mitophagy
for
treatment
These
nanoparticles
are
hypoxia-responsive
release
loaded
guest
molecules
cells.
The
released
disrupts
process,
thereby
increasing
further
weakening
Additionally,
upon
laser
irradiation,
photosensitizer
generates
reactive
oxygen
species
independent
oxygen,
inducing
damage
activation.
dual
action
simultaneous
spatiotemporal
activation
flux
blockade
results
enhanced
autophagic
stress,
ultimately
driving
cell
death.
Our
work
highlights
effectiveness
hydroxychloroquine-mediated
combined
with
mitochondria-targeted
cascade-amplified
against
has
been
recognized
as
Here,
group
fabricates
nanoparticle
codelivering
(HCQ)
sulfur-substituted
methylated
nile
blue
analog,
capable
via
Royal Society Open Science,
Год журнала:
2018,
Номер
5(9), С. 180442 - 180442
Опубликована: Сен. 1, 2018
Anastasis
is
a
natural
cell
recovery
phenomenon
that
rescues
cells
from
the
brink
of
death.
Programmed
death
such
as
apoptosis
has
been
traditionally
assumed
to
be
an
intrinsically
irreversible
cascade
commits
rapid
and
massive
demolition.
Interestingly,
recent
studies
have
demonstrated
dying
even
at
late
stages
generally
considered
immutable.
Here,
we
examine
evidence
for
anastasis
in
cultured
animals,
review
findings
illuminating
potential
mechanisms
action,
discuss
challenges
studying
explore
new
strategies
uncover
function
regulation
anastasis,
identification
which
wide-ranging
physiological,
pathological
therapeutic
implications.
PLoS Pathogens,
Год журнала:
2018,
Номер
14(8), С. e1007223 - e1007223
Опубликована: Авг. 30, 2018
Foam
cells
are
lipid-laden
macrophages
that
contribute
to
the
inflammation
and
tissue
damage
associated
with
many
chronic
inflammatory
disorders.
Although
foam
cell
biogenesis
has
been
extensively
studied
in
atherosclerosis,
how
these
form
during
a
infectious
disease
such
as
tuberculosis
is
unknown.
Here
we
report
that,
unlike
cholesterol-laden
of
tuberculous
lung
lesions
accumulate
triglycerides.
Consequently,
varies
underlying
disease.
In
vitro
mechanistic
studies
showed
triglyceride
accumulation
human
infected
Mycobacterium
mediated
by
TNF
receptor
signaling
through
downstream
activation
caspase
cascade
mammalian
target
rapamycin
complex
1
(mTORC1).
These
features
distinct
from
known
atherogenic
establish
new
paradigm
for
non-atherogenic
formation.
Moreover,
they
reveal
novel
targets
disease-specific
pharmacological
interventions
against
maladaptive
macrophage
responses.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2018,
Номер
2018(1)
Опубликована: Янв. 1, 2018
Autophagy
is
a
widely
conserved
catabolic
process
that
necessary
for
maintaining
cellular
homeostasis
under
normal
physiological
conditions
and
driving
the
cell
to
switch
back
this
status
quo
times
of
starvation,
hypoxia,
oxidative
stress.
The
potential
similarities
differences
between
basal
autophagy
stimulus‐induced
are
still
largely
unknown.
Both
act
by
clearing
aberrant
or
unnecessary
cytoplasmic
material,
such
as
misfolded
proteins,
supernumerary
defective
organelles.
relationship
reactive
oxygen
species
(ROS)
complex.
Cellular
ROS
predominantly
derived
from
mitochondria.
triggered
event,
organelles
effectively,
it
lowers
thereby
restoring
homeostasis.
However,
if
cannot
be
reached,
cells
can
choose
regulated
death
response.
Intriguingly,
autophagic
machines
both
respond
same
stresses
share
key
regulatory
suggesting
pathways
intricately
connected.
Here,
intersection
apoptosis
discussed
with
particular
focus
on
role
plays.